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Retinoic acid receptor alpha
A retinoic acid receptor alpha that is encoded in the genome of mouse. [OMA:P11416, PRO:DNx]
Synonyms
RAR-alpha;
Nuclear receptor subfamily 1 group B member 1
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tretinoin | Mus musculus (house mouse) | IC50 | 0.0057 | 3 | 3 |
| alitretinoin | Mus musculus (house mouse) | IC50 | 0.0310 | 1 | 1 |
| isotretinoin | Mus musculus (house mouse) | IC50 | 1.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cd 2019 | Mus musculus (house mouse) | EC50 | 0.0092 | 1 | 1 |
| tretinoin | Mus musculus (house mouse) | EC50 | 0.0082 | 3 | 3 |
| tretinoin | Mus musculus (house mouse) | Kd | 0.0150 | 1 | 1 |
| alitretinoin | Mus musculus (house mouse) | Kd | 0.0070 | 1 | 1 |
| ac 261066 | Mus musculus (house mouse) | EC50 | 0.0700 | 1 | 1 |
Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 29, Issue:8, 2019
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.Bioorganic & medicinal chemistry, , 02-15, Volume: 26, Issue:4, 2018
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.Journal of medicinal chemistry, , Jun-23, Volume: 38, Issue:13, 1995
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.Journal of medicinal chemistry, , Aug-30, Volume: 39, Issue:18, 1996