A sodium channel protein type 11 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UI33]
Peripheral nerve sodium channel 5;
PN5;
Sensory neuron sodium channel 2;
Sodium channel protein type XI subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.9;
hNaN
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amiodarone | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| amitriptyline | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| chlorpromazine | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| cifenline | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| imipramine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| mexiletine | Homo sapiens (human) | IC50 | 43.0000 | 1 | 1 |
| nifedipine | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| nitrendipine | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| pimozide | Homo sapiens (human) | IC50 | 0.0540 | 1 | 1 |
| diltiazem | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| sertindole | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| mibefradil | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| tedisamil | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| uk 68798 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| tetrodotoxin | Homo sapiens (human) | IC50 | 15.0150 | 2 | 2 |
| saxitoxin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| ajmaline | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
This protein enables 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel activity | molecular function | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
| axonal growth cone | cellular component | The migrating motile tip of a growing nerve cell axon. [GOC:jl, NIF_Subcellular:sao203987954] |
| C-fiber | cellular component | The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated. [NIF_Subcellular:nlx_subcell_20090210] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel complex | cellular component | A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732] |
This protein is involved in 35 target(s):
| Target | Category | Definition |
|---|---|---|
| thigmotaxis | biological process | The directed movement of an animal in response to touch. [GOC:dph] |
| acute inflammatory response | biological process | Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. [GO_REF:0000022, GOC:add, ISBN:0781735149] |
| chronic inflammatory response | biological process | Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. [GO_REF:0000022, GOC:jal, ISBN:0781735149] |
| axonogenesis | biological process | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] |
| circadian rhythm | biological process | Any biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators] |
| response to heat | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. [GOC:lr] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| response to high light intensity | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. [GOC:go_curators] |
| protein kinase A signaling | biological process | An intracellular signaling cassette that starts with the activation of protein kinase A (PKA), and ends with the regulation of a downstream cellular process, e.g. transcription. The PKA catalytic subunit (PKA-C) is normally present in a complex with its regulatory subunit, PKA-R. The inhibitory action of PKA-R is released upon cAMP binding, which results in the activation of PKA-C. [PMID:35252178, PMID:36431013] |
| response to auditory stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] |
| neuronal action potential | biological process | An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb] |
| sensory perception of pain | biological process | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators] |
| response to prostaglandin E | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:BHF, GOC:vk] |
| thermosensory behavior | biological process | Behavior that is dependent upon the sensation of temperature. [GOC:ems] |
| mast cell degranulation | biological process | The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. [ISBN:0781735149] |
| cell motility | biological process | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] |
| detection of temperature stimulus involved in sensory perception of pain | biological process | The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos] |
| detection of mechanical stimulus involved in sensory perception of pain | biological process | The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos] |
| reflex | biological process | An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. [GOC:dph, ISBN:0877797099] |
| micturition | biological process | The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body. [GOC:dph] |
| skeletal muscle organ development | biological process | The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. [GOC:dph] |
| artery development | biological process | The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. [GOC:dph, GOC:sdb_2009, GOC:tb] |
| behavioral response to acetic acid induced pain | biological process | Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus. [GOC:dph] |
| behavioral response to formalin induced pain | biological process | Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus. [GOC:dph] |
| cellular response to cold | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:jp] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |
| response to nitric oxide | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. [GOC:mah, GOC:yaf] |
| membrane depolarization during action potential | biological process | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| action potential initiation | biological process | The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate. [ISBN:978-0071390118, PMID:19439602] |
| sensory perception of itch | biological process | A sensory perception which causes the desire or reflex to scratch. [PMID:26015312, PMID:29723501, PMID:30734045, Wikipedia:Itch] |
| calcitonin gene-related peptide receptor signaling pathway | biological process | The series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers. [GOC:bhm, PMID:10882736] |
| small intestine smooth muscle contraction | biological process | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. [PMID:11991626] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |