Taste receptor type 2 member 43

A taste receptor type 2 member 43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P59537]

T2R43;
Taste receptor type 2 member 52;
T2R52

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
isoproterenol	Homo sapiens (human)	EC50	0.0049	1	0

This protein enables 3 target(s):

Target	Category	Definition
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
taste receptor activity	molecular function	Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph]
bitter taste receptor activity	molecular function	Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. [GOC:mah]

This protein is located in 4 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
motile cilium	cellular component	A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]
ciliary membrane	cellular component	The portion of the plasma membrane surrounding a cilium. [GOC:cilia, GOC:dph, GOC:rph]

This protein is active in 1 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is involved in 2 target(s):

Target	Category	Definition
detection of chemical stimulus involved in sensory perception of bitter taste	biological process	The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. [GOC:go_curators]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]