Thioredoxin reductase 3

A thioredoxin reductase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86VQ6]

EC 1.8.1.9;
Thioredoxin and glutathione reductase;
Thioredoxin reductase TR2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene	Homo sapiens (human)	IC50	100.0000	1	1
naphthazarin	Homo sapiens (human)	IC50	20.0000	1	1
2,6-dichloroindophenol	Homo sapiens (human)	IC50	25.0000	1	1
4-aminophenylarsenoxide	Homo sapiens (human)	IC50	4.0000	1	1
tetramethylpyrazine	Homo sapiens (human)	IC50	200.0000	3	3
palmarumycin cp(1)	Homo sapiens (human)	IC50	6.1750	2	2
xanthohumol	Homo sapiens (human)	IC50	40.0000	1	1
curcumin	Homo sapiens (human)	IC50	40.4667	3	3
ellagic acid	Homo sapiens (human)	IC50	176.8000	2	2
(1,2-bis(1,2-benzisoselenazolone-3(2h)-ketone))ethane	Homo sapiens (human)	IC50	5.0000	1	1
flavellagic acid	Homo sapiens (human)	IC50	46.7000	2	2

This protein enables 2 target(s):

Target	Category	Definition
thioredoxin-disulfide reductase (NADPH) activity	molecular function	Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. [RHEA:20345]
flavin adenine dinucleotide binding	molecular function	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 3 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 4 target(s):

Target	Category	Definition
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
cell differentiation	biological process	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
cell redox homeostasis	biological process	Any process that maintains the redox environment of a cell or compartment within a cell. [GOC:ai, GOC:dph, GOC:tb]
cellular oxidant detoxification	biological process	Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw]