Page last updated: 2024-08-07 15:34:05
Carbonic anhydrase 1
A vertebrate-type carbonic anhydrase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00915]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase I;
Carbonic anhydrase B;
CAB;
Carbonic anhydrase I;
CA-I
Research
Bioassay Publications (612)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (0.33) | 18.7374 |
| 1990's | 5 (0.82) | 18.2507 |
| 2000's | 163 (26.63) | 29.6817 |
| 2010's | 363 (59.31) | 24.3611 |
| 2020's | 79 (12.91) | 2.80 |
Compounds (398)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Homo sapiens (human) | Ki | 1.0800 | 1 | 1 |
| 4-hydroxyphenylacetic acid | Homo sapiens (human) | Ki | 309.0000 | 1 | 1 |
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 304.0589 | 5 | 19 |
| bromide | Homo sapiens (human) | Ki | 11,883.0000 | 2 | 6 |
| hydrobromic acid | Homo sapiens (human) | Ki | 4,000.0000 | 8 | 8 |
| cadaverine | Homo sapiens (human) | Ki | 13.3000 | 1 | 1 |
| catechol | Homo sapiens (human) | IC50 | 5.7900 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 1,418.8722 | 10 | 27 |
| chlorine | Homo sapiens (human) | Ki | 42,435.0600 | 2 | 5 |
| hydrochloric acid | Homo sapiens (human) | Ki | 6,000.0000 | 8 | 8 |
| coumarin | Homo sapiens (human) | Ki | 3.1000 | 9 | 9 |
| salicylic acid | Homo sapiens (human) | IC50 | 560.0000 | 1 | 1 |
| salicylic acid | Homo sapiens (human) | Ki | 170.9424 | 5 | 17 |
| gallic acid | Homo sapiens (human) | Ki | 604.4000 | 2 | 3 |
| 4-nitrophenylphosphate | Homo sapiens (human) | IC50 | 0.3300 | 1 | 1 |
| hydrogen sulfide | Homo sapiens (human) | Ki | 0.6000 | 8 | 8 |
| 4-aminophenol | Homo sapiens (human) | Ki | 468.1400 | 3 | 15 |
| guaiacol | Homo sapiens (human) | Ki | 93.4950 | 2 | 6 |
| cyanic acid | Homo sapiens (human) | Ki | 0.7000 | 6 | 6 |
| carbonic acid | Homo sapiens (human) | Ki | 13,600.0000 | 8 | 15 |
| hydrogen cyanide | Homo sapiens (human) | Ki | 0.5000 | 7 | 7 |
| hydrogen carbonate | Homo sapiens (human) | Ki | 23,121.6400 | 2 | 5 |
| thiocyanic acid | Homo sapiens (human) | Ki | 200.0000 | 6 | 6 |
| hydroquinone | Homo sapiens (human) | Ki | 115.6100 | 4 | 19 |
| indole | Homo sapiens (human) | Ki | 27.4000 | 1 | 1 |
| naringenin | Homo sapiens (human) | Ki | 1.1806 | 1 | 5 |
| nitrates | Homo sapiens (human) | Ki | 16,096.0875 | 5 | 8 |
| nitric acid | Homo sapiens (human) | Ki | 7,000.0000 | 5 | 5 |
| nitrites | Homo sapiens (human) | Ki | 22,132.2400 | 2 | 5 |
| phenol | Homo sapiens (human) | IC50 | 4.6300 | 1 | 1 |
| phenol | Homo sapiens (human) | Ki | 90.9377 | 14 | 31 |
| diphosphoric acid | Homo sapiens (human) | Ki | 25,800.0000 | 2 | 2 |
| pyrogallol | Homo sapiens (human) | Ki | 4.5200 | 2 | 5 |
| selenic acid | Homo sapiens (human) | Ki | 118,000.0000 | 2 | 2 |
| sulfurous acid | Homo sapiens (human) | Ki | 18,000.0000 | 6 | 6 |
| spermidine | Homo sapiens (human) | Ki | 1.4000 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 231.0000 | 2 | 2 |
| sulfuric acid | Homo sapiens (human) | Ki | 59,222.2222 | 8 | 9 |
| thiamine | Homo sapiens (human) | Ki | 0.1757 | 1 | 3 |
| catechin | Homo sapiens (human) | Ki | 2.4200 | 1 | 1 |
| beta-resorcylic acid | Homo sapiens (human) | Ki | 5.2000 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 129.7000 | 4 | 15 |
| acetazolamide | Homo sapiens (human) | IC50 | 2.9224 | 43 | 56 |
| acetazolamide | Homo sapiens (human) | Ki | 4.7619 | 477 | 607 |
| aspirin | Homo sapiens (human) | IC50 | 2,710.0000 | 1 | 1 |
| aspirin | Homo sapiens (human) | Ki | 7,530.0000 | 1 | 1 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| caffeine | Homo sapiens (human) | IC50 | 28,500.0000 | 1 | 2 |
| celecoxib | Homo sapiens (human) | IC50 | 30.0444 | 4 | 7 |
| celecoxib | Homo sapiens (human) | Ki | 46.4138 | 38 | 39 |
| chlorambucil | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| chlorthalidone | Homo sapiens (human) | Ki | 29.5737 | 3 | 18 |
| coumaphos | Homo sapiens (human) | Ki | 61.7000 | 1 | 1 |
| diclofenac | Homo sapiens (human) | IC50 | 100.0000 | 2 | 4 |
| dichlorphenamide | Homo sapiens (human) | IC50 | 1.2000 | 2 | 2 |
| dichlorphenamide | Homo sapiens (human) | Ki | 7.3101 | 99 | 141 |
| diflunisal | Homo sapiens (human) | IC50 | 3.3800 | 1 | 1 |
| diflunisal | Homo sapiens (human) | Ki | 8.4500 | 1 | 1 |
| dipyrone | Homo sapiens (human) | IC50 | 375.5000 | 1 | 2 |
| adtn | Homo sapiens (human) | Ki | 14.2300 | 1 | 3 |
| ethoxzolamide | Homo sapiens (human) | IC50 | 0.0417 | 2 | 2 |
| ethoxzolamide | Homo sapiens (human) | Ki | 1.5952 | 108 | 142 |
| furosemide | Homo sapiens (human) | Ki | 56.2043 | 3 | 18 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | Ki | 4.2000 | 1 | 1 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 7.6385 | 19 | 30 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| indapamide | Homo sapiens (human) | Ki | 3,046.2340 | 3 | 18 |
| ketoprofen | Homo sapiens (human) | IC50 | 1,233.2500 | 1 | 4 |
| mafenide | Homo sapiens (human) | Ki | 835,373,354.5191 | 52 | 60 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0469 | 4 | 4 |
| methazolamide | Homo sapiens (human) | Ki | 1.7147 | 107 | 141 |
| metolazone | Homo sapiens (human) | Ki | 22.0639 | 1 | 12 |
| fenamic acid | Homo sapiens (human) | Ki | 1.2000 | 1 | 1 |
| aminosalicylic acid | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| aminosalicylic acid | Homo sapiens (human) | Ki | 240.0000 | 1 | 1 |
| potassium chloride | Homo sapiens (human) | Ki | 6,000.0000 | 1 | 1 |
| potassium iodide | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| probenecid | Homo sapiens (human) | Ki | 10.0000 | 3 | 3 |
| propofol | Homo sapiens (human) | Ki | 98.9000 | 1 | 1 |
| resorcinol | Homo sapiens (human) | Ki | 388.5429 | 6 | 21 |
| resveratrol | Homo sapiens (human) | Ki | 2.1800 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 18.3116 | 31 | 31 |
| sulfadiazine | Homo sapiens (human) | IC50 | 12.7203 | 1 | 3 |
| sodium fluoride | Homo sapiens (human) | Ki | 300,000.0000 | 7 | 7 |
| sodium iodide | Homo sapiens (human) | Ki | 300.0000 | 7 | 7 |
| imatinib | Homo sapiens (human) | Ki | 0.0319 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | IC50 | 14.9040 | 1 | 3 |
| sulfanilamide | Homo sapiens (human) | Ki | 661,017,667.6383 | 72 | 85 |
| sulfapyridine | Homo sapiens (human) | IC50 | 14.7253 | 1 | 3 |
| sulfapyridine | Homo sapiens (human) | Ki | 32.8520 | 1 | 4 |
| sulfasalazine | Homo sapiens (human) | IC50 | 3.0400 | 1 | 1 |
| sulfasalazine | Homo sapiens (human) | Ki | 6.8700 | 1 | 1 |
| sulpiride | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| sulpiride | Homo sapiens (human) | Ki | 4.2183 | 33 | 35 |
| sulthiame | Homo sapiens (human) | Ki | 15.3299 | 27 | 42 |
| temozolomide | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| trichlormethiazide | Homo sapiens (human) | Ki | 43.7760 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| wb 4101 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 30.7149 | 53 | 78 |
| cyanides | Homo sapiens (human) | Ki | 160.0800 | 2 | 5 |
| sulfamic acid | Homo sapiens (human) | Ki | 37.8138 | 21 | 24 |
| carbostyril | Homo sapiens (human) | Ki | 7.4867 | 3 | 3 |
| ampicillin | Homo sapiens (human) | Ki | 83.0000 | 1 | 1 |
| 4-toluenesulfonamide | Homo sapiens (human) | IC50 | 13.9350 | 1 | 3 |
| 4-toluenesulfonamide | Homo sapiens (human) | Ki | 69.0036 | 32 | 37 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| 3-methylsalicylic acid | Homo sapiens (human) | IC50 | 3,070.0000 | 1 | 1 |
| 3-methylsalicylic acid | Homo sapiens (human) | Ki | 11,420.0000 | 1 | 1 |
| veratrole | Homo sapiens (human) | Ki | 10.4000 | 2 | 2 |
| 4-phenylphenol | Homo sapiens (human) | Ki | 31.0825 | 1 | 4 |
| veratric acid | Homo sapiens (human) | Ki | 6.8300 | 1 | 1 |
| 3,4-dimethylphenol | Homo sapiens (human) | IC50 | 512.5875 | 2 | 4 |
| sulfosalicylic acid | Homo sapiens (human) | IC50 | 420.0000 | 1 | 1 |
| sulfosalicylic acid | Homo sapiens (human) | Ki | 770.0000 | 1 | 1 |
| benzenearsonic acid | Homo sapiens (human) | Ki | 27,139.3589 | 14 | 17 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | Ki | 19.4992 | 3 | 5 |
| 3-hydroxybenzoic acid | Homo sapiens (human) | Ki | 2.3700 | 1 | 1 |
| alpha-resorcylic acid | Homo sapiens (human) | Ki | 0.5500 | 1 | 1 |
| methylparaben | Homo sapiens (human) | Ki | 2.6000 | 1 | 1 |
| 4-anisic acid | Homo sapiens (human) | Ki | 9.0600 | 1 | 1 |
| gamma-valerolactone | Homo sapiens (human) | Ki | 4.6900 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 415.0000 | 1 | 1 |
| phenformin | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| ethyl-p-hydroxybenzoate | Homo sapiens (human) | Ki | 7.9000 | 1 | 1 |
| sulfacetamide | Homo sapiens (human) | Ki | 11.2513 | 3 | 6 |
| methyl 4-anisate | Homo sapiens (human) | Ki | 3.8400 | 1 | 1 |
| 2-ethylhexanoic acid | Homo sapiens (human) | Ki | 450.0000 | 1 | 1 |
| carzenide | Homo sapiens (human) | IC50 | 120.0000 | 2 | 2 |
| carzenide | Homo sapiens (human) | Ki | 10.1830 | 33 | 38 |
| sodium cyanide | Homo sapiens (human) | Ki | 0.5000 | 7 | 7 |
| ditiocarb | Homo sapiens (human) | Ki | 790.0000 | 2 | 2 |
| 1,4-dimethoxybenzene | Homo sapiens (human) | Ki | 8.2100 | 1 | 1 |
| catechin | Homo sapiens (human) | Ki | 6.0775 | 2 | 4 |
| thiocyanate | Homo sapiens (human) | Ki | 8,202.0200 | 2 | 5 |
| gamma-resorcylic acid | Homo sapiens (human) | Ki | 5.7000 | 1 | 1 |
| paraoxon | Homo sapiens (human) | IC50 | 0.3380 | 1 | 1 |
| 5-chlorosalicylic acid | Homo sapiens (human) | IC50 | 4.0700 | 1 | 1 |
| 5-chlorosalicylic acid | Homo sapiens (human) | Ki | 4.1600 | 1 | 1 |
| phthalimidine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| ninhydrin | Homo sapiens (human) | Ki | 5.3800 | 1 | 1 |
| topanol 354 | Homo sapiens (human) | Ki | 63.7000 | 1 | 1 |
| benzohydroxamic acid | Homo sapiens (human) | Ki | 83.1000 | 1 | 1 |
| sodium carbonate | Homo sapiens (human) | Ki | 15,000.0000 | 8 | 8 |
| butenolide | Homo sapiens (human) | Ki | 13.6000 | 1 | 1 |
| 4-hydroxyphenylethanol | Homo sapiens (human) | Ki | 430.0000 | 1 | 1 |
| flavone | Homo sapiens (human) | Ki | 1.8850 | 2 | 2 |
| syringic acid | Homo sapiens (human) | Ki | 539.3833 | 2 | 3 |
| herniarin | Homo sapiens (human) | Ki | 5.9000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 9.3000 | 1 | 1 |
| hydroxyhydroquinone | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| delta-valerolactone | Homo sapiens (human) | Ki | 9.6000 | 1 | 1 |
| 2,6-xylenol | Homo sapiens (human) | Ki | 198.3000 | 1 | 1 |
| 3-hydroxyflavone | Homo sapiens (human) | Ki | 5.1550 | 2 | 2 |
| 2-methylcyclohexanone | Homo sapiens (human) | Ki | 8.6100 | 1 | 1 |
| 3-aminophenol | Homo sapiens (human) | Ki | 4.9000 | 1 | 1 |
| ferrocin c | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 6-methyluracil | Homo sapiens (human) | Ki | 57.7600 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 206.4539 | 3 | 15 |
| hydrofluoric acid | Homo sapiens (human) | Ki | 300,000.0000 | 7 | 7 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| 2,6-dimethoxybenzoic acid | Homo sapiens (human) | Ki | 9.6700 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 12.6000 | 1 | 1 |
| 2,4-dichloro-5-sulfamoylbenzoic acid | Homo sapiens (human) | IC50 | 7.1200 | 6 | 9 |
| benzolamide | Homo sapiens (human) | Ki | 3.0702 | 36 | 46 |
| chloric acid | Homo sapiens (human) | Ki | 540.0000 | 1 | 1 |
| carbonates | Homo sapiens (human) | Ki | 21,761.2000 | 2 | 5 |
| n-phthalylglycine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| benzeneseleninic acid | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| phosphoric acid, trisodium salt | Homo sapiens (human) | Ki | 780.0000 | 1 | 1 |
| perchloric acid | Homo sapiens (human) | Ki | 150,172.5000 | 4 | 4 |
| sodium nitrate | Homo sapiens (human) | Ki | 7,000.0000 | 7 | 7 |
| iodic acid | Homo sapiens (human) | Ki | 95,000.0000 | 1 | 1 |
| sodium pyrophosphate | Homo sapiens (human) | Ki | 25,770.0000 | 8 | 8 |
| potassium nitrate | Homo sapiens (human) | Ki | 7,000.0000 | 1 | 1 |
| sodium sulfate | Homo sapiens (human) | Ki | 63,000.0000 | 8 | 8 |
| bromic acid | Homo sapiens (human) | Ki | 4,790.0000 | 1 | 1 |
| nitrous acid | Homo sapiens (human) | Ki | 8,400.0000 | 7 | 7 |
| hydrazoic acid | Homo sapiens (human) | Ki | 1.2000 | 4 | 4 |
| fluorosulfonic acid | Homo sapiens (human) | Ki | 790.0000 | 2 | 2 |
| hydroiodic acid | Homo sapiens (human) | Ki | 300.0000 | 8 | 8 |
| sodium selenate | Homo sapiens (human) | Ki | 103,321.2500 | 8 | 8 |
| salen | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| sodium bisulfide | Homo sapiens (human) | Ki | 0.6000 | 7 | 7 |
| fluorides | Homo sapiens (human) | Ki | 180,024.8800 | 2 | 5 |
| iodine | Homo sapiens (human) | Ki | 5,393.6000 | 2 | 5 |
| fludarabine phosphate | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| butylated hydroxytoluene | Homo sapiens (human) | Ki | 245.2000 | 1 | 1 |
| 2,6-di-tert-butylphenol | Homo sapiens (human) | Ki | 274.5000 | 1 | 1 |
| sodium azide | Homo sapiens (human) | Ki | 1.2000 | 8 | 8 |
| azides | Homo sapiens (human) | Ki | 8,326.8125 | 5 | 8 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 31.4000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 1.9200 | 1 | 1 |
| 2-amino-5,6-dihydroxytetralin | Homo sapiens (human) | Ki | 15.4833 | 1 | 3 |
| 2-aminosulfonyl-benzoic acid methyl ester | Homo sapiens (human) | Ki | 18.1750 | 2 | 4 |
| foscarnet sodium | Homo sapiens (human) | Ki | 24,100.0000 | 1 | 1 |
| succinylsulfanilamide | Homo sapiens (human) | Ki | 0.2490 | 1 | 1 |
| isothiocyanic acid | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| sodium persulfate | Homo sapiens (human) | Ki | 107.0000 | 8 | 8 |
| 2-amino-9h-pyrido(2,3-b)indole | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 2,4(1h,3h)-quinazolinedione | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| calanolide b | Homo sapiens (human) | Ki | 9.3100 | 1 | 1 |
| metaperiodate | Homo sapiens (human) | Ki | 14,600.0000 | 1 | 1 |
| xanthyletine | Homo sapiens (human) | Ki | 21.5000 | 1 | 1 |
| phenylethane boronic acid | Homo sapiens (human) | Ki | 11.4000 | 1 | 1 |
| xanthoxyletin | Homo sapiens (human) | Ki | 7.7100 | 1 | 1 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 42,544.9474 | 21 | 24 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 357,463,837.1466 | 44 | 47 |
| 1,2,4-trimethoxybenzene | Homo sapiens (human) | Ki | 5.9600 | 1 | 1 |
| 2-benzothiazolesulfonamide | Homo sapiens (human) | Ki | 0.0950 | 1 | 1 |
| 2-pyrone | Homo sapiens (human) | Ki | 7.9700 | 1 | 1 |
| disulphane | Homo sapiens (human) | Ki | 2,100,249.3019 | 20 | 20 |
| zoledronic acid | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| brinzolamide | Homo sapiens (human) | Ki | 25.8638 | 51 | 61 |
| trithiocarbonic acid | Homo sapiens (human) | Ki | 8.7000 | 2 | 2 |
| piloty's acid | Homo sapiens (human) | Ki | 46.6778 | 2 | 9 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 5.2826 | 34 | 37 |
| isoscopoletin | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| 1,3-dimethyluracil | Homo sapiens (human) | Ki | 316.2000 | 1 | 1 |
| n-4-tosylglycine | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| n-4-tosylglycine | Homo sapiens (human) | Ki | 120.1000 | 1 | 1 |
| epicatechin | Homo sapiens (human) | Ki | 4.1660 | 1 | 5 |
| hesperetin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| methanesulfonamide | Homo sapiens (human) | Ki | 21.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 2,530,927,813.3841 | 31 | 36 |
| methyl gentisate | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| 4-methoxybenzohydrazide | Homo sapiens (human) | Ki | 7.8400 | 1 | 1 |
| 4-Methoxybenzamide | Homo sapiens (human) | Ki | 4.3400 | 1 | 1 |
| ethyl protocatechuate | Homo sapiens (human) | Ki | 0.6500 | 1 | 1 |
| 3-acetylcoumarin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 5-hydroxymethyluracil | Homo sapiens (human) | Ki | 49.5100 | 1 | 1 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 115.0000 | 1 | 1 |
| 4-bromophenylboric acid | Homo sapiens (human) | Ki | 11.7000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 287.7957 | 25 | 28 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | IC50 | 3.4350 | 7 | 10 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 153,571,971.5638 | 50 | 56 |
| 4-(hydroxyphenyl)acetamide | Homo sapiens (human) | Ki | 309.0000 | 1 | 1 |
| methylumbelliferyl-beta-d-xyloside | Homo sapiens (human) | Ki | 3.4000 | 1 | 1 |
| 7-amino-4-methylcoumarin | Homo sapiens (human) | Ki | 5.5600 | 1 | 1 |
| aminozolamide | Homo sapiens (human) | Ki | 9,997,742.9150 | 7 | 7 |
| 4-methylumbelliferyl-galactopyranoside | Homo sapiens (human) | Ki | 0.5900 | 1 | 1 |
| 6-hydroxyethoxzolamide | Homo sapiens (human) | Ki | 7,143,360.4643 | 7 | 7 |
| 4-methyl-N-(phenylmethyl)benzenesulfonamide | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| hepsulfam | Homo sapiens (human) | Ki | 0.1450 | 1 | 1 |
| taurineamide | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| hydrogen sulfite | Homo sapiens (human) | Ki | 27,641.9400 | 2 | 5 |
| cyanates | Homo sapiens (human) | Ki | 167.0750 | 1 | 4 |
| 3-chloro-4-hydroxyphenylacetic acid | Homo sapiens (human) | Ki | 265.0000 | 1 | 1 |
| valdecoxib | Homo sapiens (human) | IC50 | 32.4766 | 3 | 5 |
| valdecoxib | Homo sapiens (human) | Ki | 50.7955 | 35 | 36 |
| perchlorate | Homo sapiens (human) | Ki | 200,000.0000 | 1 | 1 |
| estrone-3-o-sulfamate | Homo sapiens (human) | IC50 | 0.0370 | 1 | 1 |
| estrone-3-o-sulfamate | Homo sapiens (human) | Ki | 3.0953 | 4 | 4 |
| rufinamide | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 12.3000 | 1 | 1 |
| perrhenate | Homo sapiens (human) | Ki | 110.0000 | 1 | 1 |
| 1,1'-biphenyl-4-yl-boronic acid | Homo sapiens (human) | Ki | 3.7000 | 1 | 1 |
| 4-guanidinobenzoate | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| desacetyl cephapirin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| naphthalenesulfonamide | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| chlorzolamide | Homo sapiens (human) | Ki | 0.5601 | 16 | 19 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 677,467,758.6909 | 55 | 62 |
| 4-methoxyphenylboronic acid | Homo sapiens (human) | Ki | 10.9000 | 1 | 1 |
| sorafenib | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | IC50 | 0.0310 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | Ki | 0.0358 | 63 | 77 |
| lacosamide | Homo sapiens (human) | Ki | 0.3620 | 1 | 1 |
| 3-hydroxy-quinazoline-2,4-dione | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| salophen | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| potassium bromide | Homo sapiens (human) | Ki | 4,000.0000 | 1 | 1 |
| sodium bromide | Homo sapiens (human) | Ki | 4,000.0000 | 7 | 7 |
| n,n'-bis(salicylidene)-1,6-hexanediamine | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| methyl 3,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| u-104 | Homo sapiens (human) | Ki | 5.0800 | 19 | 19 |
| diba-1 | Homo sapiens (human) | Ki | 3.7356 | 3 | 5 |
| bortezomib | Homo sapiens (human) | Ki | 1.2900 | 2 | 2 |
| 1-hydroxy-2,1-benzoxaborole | Homo sapiens (human) | Ki | 5.6900 | 2 | 2 |
| naringenin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| scopolin | Homo sapiens (human) | Ki | 5.9300 | 1 | 1 |
| taxifolin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| eriodictyol | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 2.2100 | 1 | 1 |
| rwj 37947 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 206.9633 | 2 | 3 |
| diethylstilbestrol | Homo sapiens (human) | IC50 | 91.5000 | 1 | 2 |
| bay 57-1293 | Homo sapiens (human) | Ki | 0.3230 | 1 | 1 |
| sodium thiocyanate | Homo sapiens (human) | Ki | 200.0000 | 6 | 6 |
| sodium bicarbonate | Homo sapiens (human) | Ki | 12,000.0000 | 9 | 9 |
| sodium acetate, anhydrous | Homo sapiens (human) | Ki | 10.8000 | 1 | 1 |
| sodium benzoate | Homo sapiens (human) | Ki | 730.0000 | 1 | 1 |
| sodium cyanate | Homo sapiens (human) | Ki | 0.7000 | 5 | 5 |
| sodium perchlorate | Homo sapiens (human) | Ki | 200,000.0000 | 8 | 8 |
| potassium fluoride | Homo sapiens (human) | Ki | 300,000.0000 | 1 | 1 |
| ditiocarb sodium | Homo sapiens (human) | Ki | 395.3950 | 8 | 8 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 3.2000 | 3 | 3 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 379.0175 | 2 | 4 |
| piperine | Homo sapiens (human) | IC50 | 31,000.0000 | 1 | 2 |
| pyrophosphate | Homo sapiens (human) | Ki | 25,800.0000 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Ki | 0.0293 | 1 | 1 |
| ethyl coumarate | Homo sapiens (human) | Ki | 0.3200 | 1 | 1 |
| 2-amino-4-(5-methyl-2-furanyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile | Homo sapiens (human) | Ki | 89.0000 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 2.3800 | 1 | 1 |
| 1-(4-chlorophenyl)-3-(4-sulfamoylphenyl)urea | Homo sapiens (human) | Ki | 2.1500 | 1 | 1 |
| ethyl 2,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 224.0000 | 1 | 1 |
| 7-acetoxycoumarin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| formic acid, sodium salt | Homo sapiens (human) | Ki | 1,040.0000 | 1 | 1 |
| sodium propionate | Homo sapiens (human) | Ki | 1,010.0000 | 1 | 1 |
| 2-amino-5-mercapto-1,3,4-thiadiazole | Homo sapiens (human) | Ki | 7.1000 | 1 | 1 |
| N1-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide | Homo sapiens (human) | Ki | 10.0823 | 4 | 7 |
| 4-methylumbelliferyl glucoside | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| ranitidine | Homo sapiens (human) | Ki | 42.2000 | 1 | 2 |
| 6,7,8-trimethoxycoumarin | Homo sapiens (human) | Ki | 0.0097 | 1 | 1 |
| 2,6-dibromosulfanilamide | Homo sapiens (human) | Ki | 6.0707 | 5 | 8 |
| benzene-1-3-disulfonamide | Homo sapiens (human) | Ki | 11.7128 | 12 | 12 |
| 4-azidosulfanilamide | Homo sapiens (human) | Ki | 2.8074 | 5 | 7 |
| d 609 | Homo sapiens (human) | Ki | 0.0634 | 1 | 1 |
| sc 560 | Homo sapiens (human) | IC50 | 100.0000 | 2 | 4 |
| sitagliptin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| sodium hexafluorophosphate | Homo sapiens (human) | Ki | 11,000.0000 | 1 | 1 |
| sodium butyrate | Homo sapiens (human) | Ki | 511.0000 | 1 | 1 |
| isoselenocyanic acid | Homo sapiens (human) | Ki | 8.5000 | 1 | 1 |
| fraxin | Homo sapiens (human) | Ki | 5.0400 | 1 | 1 |
| fraxetin | Homo sapiens (human) | Ki | 4.8600 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 29.9138 | 4 | 8 |
| biochanin a | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| apigenin | Homo sapiens (human) | Ki | 6.8750 | 1 | 4 |
| luteolin | Homo sapiens (human) | Ki | 4.5480 | 2 | 5 |
| scopoletin | Homo sapiens (human) | Ki | 10.5600 | 1 | 1 |
| hymecromone | Homo sapiens (human) | Ki | 61.9100 | 2 | 5 |
| quercetin 3-o-glucopyranoside | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| kaempferol | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| esculetin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | Ki | 46.3000 | 4 | 4 |
| chrysin | Homo sapiens (human) | Ki | 6.9700 | 3 | 3 |
| galangin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 3-methylquercetin | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| morin | Homo sapiens (human) | Ki | 13.5500 | 1 | 4 |
| daidzein | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| salvianolic acid a | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| puerarin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | Ki | 105.8800 | 3 | 4 |
| 7-hydroxyflavone | Homo sapiens (human) | Ki | 3.4000 | 2 | 2 |
| astragalin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | Ki | 446,460,755.6997 | 85 | 112 |
| topiramate | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| topiramate | Homo sapiens (human) | Ki | 8.4445 | 70 | 96 |
| irosustat | Homo sapiens (human) | Ki | 54.6890 | 2 | 13 |
| methyl-p-coumarate | Homo sapiens (human) | Ki | 0.7800 | 1 | 1 |
| tiliroside | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 5,7-dihydroxy-4-methylcoumarin | Homo sapiens (human) | Ki | 53.7475 | 1 | 4 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | Ki | 53.8925 | 1 | 4 |
| 3-cyano-7-hydroxycoumarin | Homo sapiens (human) | Ki | 48.2209 | 1 | 11 |
| ceftriaxone | Homo sapiens (human) | Ki | 22.1500 | 1 | 2 |
| famotidine | Homo sapiens (human) | Ki | 0.9224 | 1 | 1 |
| geiparvarin | Homo sapiens (human) | Ki | 9.7500 | 1 | 1 |
| benzeneselenol | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| selenocyanic acid | Homo sapiens (human) | Ki | 8.5000 | 1 | 1 |
| lithospermic acid | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| ceftizoxime | Homo sapiens (human) | Ki | 68.9500 | 1 | 2 |
| 6-hydroxybenzothiazide-2-sulfonamide | Homo sapiens (human) | Ki | 2,499,641.9402 | 19 | 22 |
| sodium bisulfate | Homo sapiens (human) | Ki | 990.0000 | 5 | 5 |
| lenvatinib | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| tetraborate | Homo sapiens (human) | Ki | 640.0000 | 1 | 1 |
| sodium | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| acesulfame potassium | Homo sapiens (human) | Ki | 20.0000 | 3 | 3 |
| tavaborole | Homo sapiens (human) | Ki | 2.0150 | 1 | 1 |
| trans-avicennol | Homo sapiens (human) | Ki | 8.4600 | 1 | 1 |
| tannins | Homo sapiens (human) | Ki | 75.9000 | 1 | 1 |
| cryolite | Homo sapiens (human) | Ki | 52,400.0000 | 1 | 1 |
| endiandrin a | Homo sapiens (human) | Ki | 368.0000 | 1 | 1 |
| sodium bisulfite | Homo sapiens (human) | Ki | 18,000.0000 | 7 | 7 |
| sodium nitrite | Homo sapiens (human) | Ki | 8,400.0000 | 8 | 8 |
| dodoneine | Homo sapiens (human) | Ki | 5.4800 | 1 | 1 |
| dexamethasone phosphate(2-) | Homo sapiens (human) | IC50 | 4,648.7500 | 1 | 4 |
| ve 821 | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| dihydroxyfumarate | Homo sapiens (human) | Ki | 4.4100 | 1 | 1 |
| 4-hydroxycoumarin | Homo sapiens (human) | Ki | 95.0000 | 1 | 1 |
| vx-970 | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 4-hydroxyquinazoline | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| tirapazamine | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of phenolic acids.Chemical biology & drug design, , Volume: 75, Issue:5, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Natural product coumarins that inhibit human carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.Journal of medicinal chemistry, , Jan-10, Volume: 56, Issue:1, 2013
5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.Bioorganic & medicinal chemistry, , Oct-15, Volume: 16, Issue:20, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of α- but not of β-, γ- and ζ-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 20, Issue:21, 2010
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 18, Issue:7, 2008
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
α-Carbonic anhydrases are strongly activated by spinaceamine derivatives.Bioorganic & medicinal chemistry, , 03-01, Volume: 27, Issue:5, 2019
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
Carbonic anhydrases activation with 3-amino-1H-1,2,4-triazole-1-carboxamides: Discovery of subnanomolar isoform II activators.Bioorganic & medicinal chemistry, , 03-01, Volume: 25, Issue:5, 2017
Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 21, Issue:16, 2011
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 17, Issue:3, 2007
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.Bioorganic & medicinal chemistry letters, , Apr-22, Volume: 12, Issue:8, 2002
Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties.Bioorganic & medicinal chemistry letters, , Jul-19, Volume: 9, Issue:14, 1999
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation.Bioorganic & medicinal chemistry, , 08-01, Volume: 67, 2022
[no title available]Journal of medicinal chemistry, , 11-10, Volume: 65, Issue:21, 2022
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 70, 2022
Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101.Journal of medicinal chemistry, , 10-27, Volume: 65, Issue:20, 2022
[no title available]Journal of medicinal chemistry, , 10-13, Volume: 65, Issue:19, 2022
Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach.European journal of medicinal chemistry, , Mar-15, Volume: 232, 2022
Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases.European journal of medicinal chemistry, , Apr-15, Volume: 234, 2022
Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 59, 2022
Synthesis, carbonic anhydrase enzyme inhibition evaluations, and anticancer studies of sulfonamide based thiadiazole derivatives.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 57, 2022
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.Journal of medicinal chemistry, , 01-13, Volume: 65, Issue:1, 2022
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 51, 2021
Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Developments of small molecules as inhibitors for carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , 06-01, Volume: 39, 2021
Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
3-Functionalised benzenesulphonamide based 1,3,4-oxadiazoles as selective carbonic anhydrase XIII inhibitors: Design, synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , 04-01, Volume: 37, 2021
Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide - A new caspase-activating proapoptotic agent.European journal of medicinal chemistry, , Oct-15, Volume: 222, 2021
[no title available]European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides.European journal of medicinal chemistry, , May-05, Volume: 217, 2021
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold.European journal of medicinal chemistry, , Aug-05, Volume: 220, 2021
Insertion of metal carbenes into the anilinic N-H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Synthesis and biological evaluation of novel 4,7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 39, 2021
Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II.European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 48, 2021
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 45, 2021
Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 53, 2021
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Discovery of first-in-class multi-target adenosine AEuropean journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 07-09, Volume: 63, Issue:13, 2020
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity.Journal of medicinal chemistry, , 04-23, Volume: 63, Issue:8, 2020
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors.European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Tail approach synthesis of novel benzenesulfonamides incorporating 1,3,4-oxadiazole hybrids as potent inhibitor of carbonic anhydrase I, II, IX, and XII isoenzymes.European journal of medicinal chemistry, , May-01, Volume: 193, 2020
Discovery of New 1,1'-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation.Bioorganic & medicinal chemistry, , 08-01, Volume: 28, Issue:15, 2020
Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Synthesis and evaluation of 4-(1,3,4-oxadiazol-2-yl)-benzenesulfonamides as potent carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 30, Issue:2, 2020
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
[no title available]European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.Journal of medicinal chemistry, , 03-12, Volume: 63, Issue:5, 2020
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.European journal of medicinal chemistry, , Mar-01, Volume: 189, 2020
Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate.European journal of medicinal chemistry, , Jul-15, Volume: 198, 2020
Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies.Bioorganic & medicinal chemistry, , 03-01, Volume: 28, Issue:5, 2020
Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , 06-01, Volume: 28, Issue:11, 2020
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.Journal of medicinal chemistry, , 07-09, Volume: 63, Issue:13, 2020
[no title available]ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 03-12, Volume: 63, Issue:5, 2020
In Silico-Guided Identification of New Potent Inhibitors of Carbonic Anhydrases Expressed in ACS medicinal chemistry letters, , Nov-12, Volume: 11, Issue:11, 2020
Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure.Bioorganic & medicinal chemistry, , 11-01, Volume: 27, Issue:21, 2019
New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Aug-08, Volume: 10, Issue:8, 2019
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 08-08, Volume: 62, Issue:15, 2019
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
[no title available]ACS medicinal chemistry letters, , Apr-11, Volume: 10, Issue:4, 2019
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment.European journal of medicinal chemistry, , Feb-15, Volume: 164, 2019
Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 27, Issue:8, 2019
5-Arylisothiazol-3(2H)-one-1,(1)-(di)oxides: A new class of selective tumor-associated carbonic anhydrases (hCA IX and XII) inhibitors.European journal of medicinal chemistry, , Aug-01, Volume: 175, 2019
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors.Bioorganic & medicinal chemistry, , 11-01, Volume: 27, Issue:21, 2019
Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights.European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.Journal of medicinal chemistry, , 12-13, Volume: 61, Issue:23, 2018
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.Journal of medicinal chemistry, , 07-26, Volume: 61, Issue:14, 2018
2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.European journal of medicinal chemistry, , May-10, Volume: 151, 2018
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors.Journal of medicinal chemistry, , 07-12, Volume: 61, Issue:13, 2018
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation.Journal of medicinal chemistry, , 04-12, Volume: 61, Issue:7, 2018
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.ACS medicinal chemistry letters, , Sep-13, Volume: 9, Issue:9, 2018
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 06-14, Volume: 61, Issue:11, 2018
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.European journal of medicinal chemistry, , Jun-25, Volume: 154, 2018
Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors.ACS medicinal chemistry letters, , Jul-12, Volume: 9, Issue:7, 2018
Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.MedChemComm, , Dec-01, Volume: 9, Issue:12, 2018
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.European journal of medicinal chemistry, , May-25, Volume: 152, 2018
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.Journal of medicinal chemistry, , 06-28, Volume: 61, Issue:12, 2018
Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity.Chembiochem : a European journal of chemical biology, , Jan-17, Volume: 18, Issue:2, 2017
Synthesis, characterization, anticancer, antimicrobial and carbonic anhydrase inhibition profiles of novel (3aR,4S,7R,7aS)-2-(4-((E)-3-(3-aryl)acryloyl) phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives.Bioorganic chemistry, , Volume: 70, 2017
Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study.ACS medicinal chemistry letters, , Nov-09, Volume: 8, Issue:11, 2017
Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
[no title available]European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1,3,4-thiadiazole derivatives.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.Bioorganic & medicinal chemistry, , 03-01, Volume: 25, Issue:5, 2017
Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.ACS medicinal chemistry letters, , Oct-12, Volume: 8, Issue:10, 2017
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties.Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.Bioorganic & medicinal chemistry, , 05-01, Volume: 25, Issue:9, 2017
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.Journal of medicinal chemistry, , 07-27, Volume: 60, Issue:14, 2017
Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.Journal of medicinal chemistry, , 03-23, Volume: 60, Issue:6, 2017
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , 05-15, Volume: 25, Issue:10, 2017
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry, , 09-01, Volume: 25, Issue:17, 2017
Inhibition of Malassezia globosa carbonic anhydrase with phenols.Bioorganic & medicinal chemistry, , 05-01, Volume: 25, Issue:9, 2017
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
[no title available]Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.Journal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties.Bioorganic & medicinal chemistry, , 02-15, Volume: 25, Issue:4, 2017
Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.Bioorganic & medicinal chemistry, , 09-01, Volume: 25, Issue:17, 2017
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
[no title available]ACS medicinal chemistry letters, , Aug-10, Volume: 8, Issue:8, 2017
Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds.Bioorganic & medicinal chemistry, , 03-15, Volume: 25, Issue:6, 2017
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Bortezomib inhibits bacterial and fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Microwave assisted synthesis of novel acridine-acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.European journal of medicinal chemistry, , Mar-03, Volume: 110, 2016
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-15, Volume: 24, Issue:2, 2016
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
[no title available]Bioorganic & medicinal chemistry letters, , 12-15, Volume: 26, Issue:24, 2016
An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 26, Issue:4, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.Journal of medicinal chemistry, , 12-08, Volume: 59, Issue:23, 2016
Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds.Bioorganic & medicinal chemistry, , 05-15, Volume: 24, Issue:10, 2016
Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma.Bioorganic & medicinal chemistry, , Mar-15, Volume: 24, Issue:6, 2016
PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.Journal of medicinal chemistry, , 05-26, Volume: 59, Issue:10, 2016
Novel sulfonamide bearing coumarin scaffolds as selective inhibitors of tumor associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.Bioorganic & medicinal chemistry, , Jan-01, Volume: 24, Issue:1, 2016
Synthesis and carbonic anhydrase inhibitory effects of new N-glycosylsulfonamides incorporating the phenol moiety.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 26, Issue:4, 2016
4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies.Journal of medicinal chemistry, , Jan-28, Volume: 59, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects.Chemical biology & drug design, , Volume: 87, Issue:4, 2016
Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site.Journal of medicinal chemistry, , Feb-12, Volume: 58, Issue:3, 2015
New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.European journal of medicinal chemistry, , Volume: 96, 2015
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.ACS medicinal chemistry letters, , Jul-09, Volume: 6, Issue:7, 2015
Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.Journal of medicinal chemistry, , Nov-12, Volume: 58, Issue:21, 2015
Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.Journal of medicinal chemistry, , Jan-22, Volume: 58, Issue:2, 2015
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 25, Issue:17, 2015
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Oct-15, Volume: 23, Issue:20, 2015
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.Journal of medicinal chemistry, , May-14, Volume: 58, Issue:9, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:1, 2014
Sulfonamides with Potent Inhibitory Action and Selectivity against the α-Carbonic Anhydrase from Vibrio cholerae.ACS medicinal chemistry letters, , Jul-10, Volume: 5, Issue:7, 2014
Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.ACS medicinal chemistry letters, , Jul-10, Volume: 5, Issue:7, 2014
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.Journal of medicinal chemistry, , Nov-13, Volume: 57, Issue:21, 2014
Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Quinazoline-sulfonamides with potent inhibitory activity against the α-carbonic anhydrase from Vibrio cholerae.Bioorganic & medicinal chemistry, , Oct-01, Volume: 22, Issue:19, 2014
Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 24, Issue:4, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.ACS medicinal chemistry letters, , Aug-14, Volume: 5, Issue:8, 2014
Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis γ-carbonic anhydrase.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 24, Issue:16, 2014
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.Bioorganic & medicinal chemistry, , May-01, Volume: 22, Issue:9, 2014
Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 24, Issue:7, 2014
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 24, Issue:5, 2014
Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanopheBioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.Bioorganic & medicinal chemistry, , Nov-15, Volume: 22, Issue:22, 2014
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 24, Issue:5, 2014
Kinetic and in silico analysis of thiazolidin-based inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
A prodrug approach toward cancer-related carbonic anhydrase inhibition.Journal of medicinal chemistry, , Dec-12, Volume: 56, Issue:23, 2013
Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII.Bioorganic & medicinal chemistry, , Sep-15, Volume: 21, Issue:18, 2013
A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 23, Issue:14, 2013
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 23, Issue:12, 2013
Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl)benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over I and II with potential anticancer activity.European journal of medicinal chemistry, , Volume: 66, 2013
Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.Journal of medicinal chemistry, , Jan-10, Volume: 56, Issue:1, 2013
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.European journal of medicinal chemistry, , Volume: 62, 2013
o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Synthesis and characterization of phenolic Mannich bases and effects of these compounds on human carbonic anhydrase isozymes I and II.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Synthesis and characterization of metal complexes of heterocyclic sulfonamide as carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
A class of sulfonamides with strong inhibitory action against the α-carbonic anhydrase from Trypanosoma cruzi.Journal of medicinal chemistry, , Jul-25, Volume: 56, Issue:14, 2013
Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.Bioorganic & medicinal chemistry, , Jul-01, Volume: 21, Issue:13, 2013
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.Bioorganic & medicinal chemistry, , Apr-15, Volume: 21, Issue:8, 2013
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:3, 2012
Carbonic anhydrase I and II inhibition with natural products: caffeine and piperine.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:1, 2012
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.Journal of medicinal chemistry, , Feb-23, Volume: 55, Issue:4, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Synthesis and characterization of novel dioxoacridine sulfonamide derivatives as new carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:4, 2012
α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:1, 2012
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 22, Issue:18, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:6, 2011
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Virtual screening-driven identification of human carbonic anhydrase inhibitors incorporating an original, new pharmacophore.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Synthesis of glycoconjugate carbonic anhydrase inhibitors by ruthenium-catalysed azide-alkyne 1,3-dipolar cycloaddition.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Synthesis of 5-amino-1,3,4-thiadiazole-2-sulphonamide derivatives and their inhibition effects on human carbonic anhydrase isozymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:2, 2011
Synthesis and characterisation of two novel proton transfer compounds and their inhibition studies on carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:1, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of phenolic acids.Chemical biology & drug design, , Volume: 75, Issue:5, 2010
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 20, Issue:7, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII.Bioorganic & medicinal chemistry, , Nov-01, Volume: 18, Issue:21, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.Bioorganic & medicinal chemistry, , Jan-15, Volume: 18, Issue:2, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide.European journal of medicinal chemistry, , Volume: 45, Issue:11, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 19, Issue:20, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.Journal of medicinal chemistry, , Aug-13, Volume: 52, Issue:15, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009
Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 17, Issue:2, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.Chemical biology & drug design, , Volume: 74, Issue:6, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Oct-22, Volume: 52, Issue:20, 2009
Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Effects of new 5-amino-1,3,4-thiadiazole-2-sulfonamide derivatives on human carbonic anhydrase isozymes.Bioorganic & medicinal chemistry, , May-01, Volume: 17, Issue:9, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 18, Issue:7, 2008
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.Bioorganic & medicinal chemistry, , Nov-15, Volume: 15, Issue:22, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX.Journal of medicinal chemistry, , May-04, Volume: 49, Issue:9, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumoBioorganic & medicinal chemistry letters, , Jul-01, Volume: 15, Issue:13, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.Journal of medicinal chemistry, , Oct-07, Volume: 47, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.Journal of enzyme inhibition, , Volume: 16, Issue:4, 2001
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Designed multiple ligands. An emerging drug discovery paradigm.Journal of medicinal chemistry, , Oct-20, Volume: 48, Issue:21, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.Journal of medicinal chemistry, , Oct-07, Volume: 47, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.MedChemComm, , Dec-01, Volume: 9, Issue:12, 2018
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:1, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 24, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 23, Issue:12, 2013
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumoBioorganic & medicinal chemistry letters, , Jul-01, Volume: 15, Issue:13, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.Journal of medicinal chemistry, , Oct-07, Volume: 47, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:1, 2014
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII.Bioorganic & medicinal chemistry, , Nov-01, Volume: 18, Issue:21, 2010
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.Bioorganic & medicinal chemistry, , Dec-01, Volume: 23, Issue:23, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.European journal of medicinal chemistry, , Volume: 62, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , Jun-15, Volume: 19, Issue:12, 2011
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.Journal of medicinal chemistry, , Oct-07, Volume: 47, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.Journal of medicinal chemistry, , 02-08, Volume: 61, Issue:3, 2018
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.Journal of medicinal chemistry, , Apr-24, Volume: 57, Issue:8, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.Bioorganic & medicinal chemistry, , Dec-01, Volume: 23, Issue:23, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 24, Issue:7, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
2-Amino-3-cyanopyridine derivatives as carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
Synthesis and characterization of novel dioxoacridine sulfonamide derivatives as new carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:4, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 20, Issue:7, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumoBioorganic & medicinal chemistry letters, , Jul-01, Volume: 15, Issue:13, 2005
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.Chemical biology & drug design, , Volume: 74, Issue:6, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
[no title available]European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Oct-22, Volume: 52, Issue:20, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.Bioorganic & medicinal chemistry letters, , Apr-22, Volume: 12, Issue:8, 2002
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.ACS medicinal chemistry letters, , Sep-13, Volume: 9, Issue:9, 2018
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.Bioorganic & medicinal chemistry, , Dec-01, Volume: 23, Issue:23, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.Bioorganic & medicinal chemistry letters, , May-01, Volume: 19, Issue:9, 2009
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 16, Issue:19, 2006
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.Bioorganic & medicinal chemistry letters, , Apr-22, Volume: 12, Issue:8, 2002
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.Bioorganic & medicinal chemistry, , Dec-01, Volume: 23, Issue:23, 2015
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 21, Issue:7, 2013
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:5, 2012
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity.Journal of the American Chemical Society, , Mar-08, Volume: 128, Issue:9, 2006
Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 51, 2021
Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 53, 2021
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Synthesis and characterisation of two novel proton transfer compounds and their inhibition studies on carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:1, 2011
Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.Bioorganic & medicinal chemistry, , Jan-15, Volume: 18, Issue:2, 2010
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 19, Issue:7, 2009
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 25, Issue:21, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 19, Issue:7, 2009
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 19, Issue:7, 2009
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Bortezomib inhibits bacterial and fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.Bioorganic & medicinal chemistry letters, , May-15, Volume: 19, Issue:10, 2009
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.Bioorganic & medicinal chemistry, , Dec-01, Volume: 23, Issue:23, 2015
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 26, Issue:5, 2016
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 18, Issue:18, 2008
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Synthesis of 5-amino-1,3,4-thiadiazole-2-sulphonamide derivatives and their inhibition effects on human carbonic anhydrase isozymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide.European journal of medicinal chemistry, , Volume: 45, Issue:11, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Effects of new 5-amino-1,3,4-thiadiazole-2-sulfonamide derivatives on human carbonic anhydrase isozymes.Bioorganic & medicinal chemistry, , May-01, Volume: 17, Issue:9, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.Bioorganic & medicinal chemistry, , Nov-15, Volume: 15, Issue:22, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.European journal of medicinal chemistry, , Volume: 49, 2012
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.Bioorganic & medicinal chemistry letters, , Feb-10, Volume: 13, Issue:3, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 26, Issue:4, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.Journal of medicinal chemistry, , 01-13, Volume: 65, Issue:1, 2022
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
[no title available]ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 27, Issue:8, 2019
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.Journal of medicinal chemistry, , 07-26, Volume: 61, Issue:14, 2018
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.Bioorganic & medicinal chemistry, , 05-01, Volume: 25, Issue:9, 2017
Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Bortezomib inhibits bacterial and fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry, , 09-15, Volume: 24, Issue:18, 2016
Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study.ACS medicinal chemistry letters, , Nov-09, Volume: 8, Issue:11, 2017
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
[no title available]Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , 01-01, Volume: 27, Issue:1, 2017
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 23, Issue:4, 2013
The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 22, Issue:20, 2012
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 16, Issue:15, 2006
Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.Bioorganic & medicinal chemistry letters, , Apr-22, Volume: 12, Issue:8, 2002
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.Journal of medicinal chemistry, , Feb-23, Volume: 55, Issue:4, 2012
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 19, Issue:7, 2009
5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 26, Issue:8, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of phenolic acids.Chemical biology & drug design, , Volume: 75, Issue:5, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
New natural product carbonic anhydrase inhibitors incorporating phenol moieties.Bioorganic & medicinal chemistry, , Nov-15, Volume: 23, Issue:22, 2015
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.Bioorganic & medicinal chemistry letters, , May-01, Volume: 22, Issue:9, 2012
Natural product coumarins that inhibit human carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Inhibition of human erythrocyte isozymes I and II with a series of phenolic acids.Chemical biology & drug design, , Volume: 75, Issue:5, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.Journal of medicinal chemistry, , 03-26, Volume: 63, Issue:6, 2020
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.Journal of medicinal chemistry, , 06-28, Volume: 61, Issue:12, 2018
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects.Chemical biology & drug design, , Volume: 87, Issue:4, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.Bioorganic & medicinal chemistry, , Sep-15, Volume: 23, Issue:18, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.Journal of medicinal chemistry, , Oct-07, Volume: 47, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 13, Issue:17, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.Bioorganic & medicinal chemistry letters, , Jun-17, Volume: 12, Issue:12, 2002
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.Journal of medicinal chemistry, , Dec-14, Volume: 43, Issue:25, 2000
Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties.Bioorganic & medicinal chemistry letters, , Apr-03, Volume: 10, Issue:7, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.Journal of medicinal chemistry, , 03-25, Volume: 64, Issue:6, 2021
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.Journal of medicinal chemistry, , 03-23, Volume: 60, Issue:6, 2017
[no title available]Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
[no title available]Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 26, Issue:17, 2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.Bioorganic & medicinal chemistry, , Feb-01, Volume: 23, Issue:3, 2015
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.Bioorganic & medicinal chemistry, , Jun-01, Volume: 22, Issue:11, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.Journal of medicinal chemistry, , Feb-28, Volume: 56, Issue:4, 2013
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Mar-10, Volume: 54, Issue:5, 2011
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
N-β-glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 21, Issue:15, 2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.Journal of medicinal chemistry, , Jun-09, Volume: 54, Issue:11, 2011
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 17, Issue:10, 2009
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Oct-22, Volume: 52, Issue:20, 2009
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.Journal of medicinal chemistry, , Feb-26, Volume: 47, Issue:5, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.Bioorganic & medicinal chemistry letters, , Mar-10, Volume: 13, Issue:5, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.Bioorganic & medicinal chemistry, , Feb-15, Volume: 20, Issue:4, 2012
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.Bioorganic & medicinal chemistry, , Feb-01, Volume: 19, Issue:3, 2011
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.Bioorganic & medicinal chemistry, , Aug-15, Volume: 19, Issue:16, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 16, Issue:7, 2006
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.Journal of medicinal chemistry, , Mar-23, Volume: 49, Issue:6, 2006
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.Journal of medicinal chemistry, , Mar-28, Volume: 45, Issue:7, 2002
Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.Bioorganic & medicinal chemistry letters, , Feb-26, Volume: 11, Issue:4, 2001
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?Journal of medicinal chemistry, , Jul-15, Volume: 42, Issue:14, 1999
Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 22, Issue:3, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 19, Issue:7, 2009
"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.Journal of medicinal chemistry, , 02-08, Volume: 61, Issue:3, 2018
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 24, Issue:18, 2014
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 22, Issue:23, 2012
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax.Bioorganic & medicinal chemistry, , Jan-15, Volume: 19, Issue:2, 2011
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| arylesterase activity | molecular function | Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. [EC:3.1.1.2] |
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| hydro-lyase activity | molecular function | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. [EC:4.2.1.-] |
| cyanamide hydratase activity | molecular function | Catalysis of the reaction: urea = cyanamide + H2O. [EC:4.2.1.69, RHEA:23056] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |