Nucleoside diphosphate kinase B

A nucleoside diphosphate kinase B that is encoded in the genome of human. [PRO:DAN, UniProtKB:P22392]

Synonyms

NDK B;
NDP kinase B;
EC 2.7.4.6;
C-myc purine-binding transcription factor PUF;
Histidine protein kinase NDKB;
2.7.13.3;
nm23-H2

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (17)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alvocidib	Homo sapiens (human)	Kd	30.0000	1	1
saracatinib	Homo sapiens (human)	Kd	30.0000	1	1
vx 702	Homo sapiens (human)	Kd	30.0000	1	1
chir-265	Homo sapiens (human)	Kd	30.0000	1	1
pf-562,271	Homo sapiens (human)	Kd	30.0000	1	1
buparlisib	Homo sapiens (human)	Kd	30.0000	1	2
pha 848125	Homo sapiens (human)	Kd	30.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	30.0000	1	1
cudc 101	Homo sapiens (human)	Kd	0.1420	1	1
mln 8237	Homo sapiens (human)	Kd	30.0000	1	1
pci 32765	Homo sapiens (human)	Kd	30.0000	1	1
tak 733	Homo sapiens (human)	Kd	30.0000	1	1
entrectinib	Homo sapiens (human)	Kd	30.0000	1	1
gsk 2126458	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	30.0000	1	1
osimertinib	Homo sapiens (human)	Kd	30.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
thymidine 5'-diphosphate	Homo sapiens (human)	Activity	1.4000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
transcription coactivator activity	molecular function	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
nucleoside diphosphate kinase activity	molecular function	Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]
protein histidine kinase activity	molecular function	Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. [EC:2.7.13.3, GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
GDP binding	molecular function	Binding to GDP, guanosine 5'-diphosphate. [GOC:ai]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
G-quadruplex DNA binding	molecular function	Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. [PMID:16142245, PMID:9512530]

Located In

This protein is located in 11 target(s):

Target	Category	Definition
ruffle	cellular component	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. [ISBN:0124325653]
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
lamellipodium	cellular component	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]
secretory granule lumen	cellular component	The volume enclosed by the membrane of a secretory granule. [GOC:rph]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
cell periphery	cellular component	The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. [GOC:pdt]
ficolin-1-rich granule lumen	cellular component	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
GTP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. [ISBN:0198506732]
UTP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. [ISBN:0198506732]
CTP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. [ISBN:0198506732]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
integrin-mediated signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
nucleoside triphosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of keratinocyte differentiation	biological process	Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. [GOC:go_curators]
regulation of epidermis development	biological process	Any process that modulates the frequency, rate or extent of epidermis development. [GOC:go_curators]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of epithelial cell proliferation	biological process	Any process that activates or increases the rate or extent of epithelial cell proliferation. [GOC:ai]
regulation of apoptotic process	biological process	Any process that modulates the occurrence or rate of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]