chlorambucil has been researched along with Necrosis in 12 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of a new oil-soluble anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol (LPD) was investigated as intraarterial chemotherapy, using 40 Wistar rats bearing Walker 256 carcinosarcoma in the extremities." | 7.68 | Effects of intraarterial chemotherapy using the new lipophilic anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol on Walker 256 carcinosarcoma in Wistar rats--a preliminary report. ( Asano, K; Bannai, K; Egawa, H; Mitsuhashi, S; Mori, K; Ozawa, K, 1990) |
| "In this case report the clinical course of a female patient with metastatic breast cancer receiving a mild cytostatic regimen with chlorambucil, methotrexate and prednisone is described." | 7.67 | [Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone]. ( Voigtmann, R, 1989) |
| "The effect of a new oil-soluble anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol (LPD) was investigated as intraarterial chemotherapy, using 40 Wistar rats bearing Walker 256 carcinosarcoma in the extremities." | 3.68 | Effects of intraarterial chemotherapy using the new lipophilic anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol on Walker 256 carcinosarcoma in Wistar rats--a preliminary report. ( Asano, K; Bannai, K; Egawa, H; Mitsuhashi, S; Mori, K; Ozawa, K, 1990) |
| "In this case report the clinical course of a female patient with metastatic breast cancer receiving a mild cytostatic regimen with chlorambucil, methotrexate and prednisone is described." | 3.67 | [Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone]. ( Voigtmann, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mourtada, R | 1 |
| Fonseca, SB | 1 |
| Wisnovsky, SP | 1 |
| Pereira, MP | 2 |
| Wang, X | 1 |
| Hurren, R | 1 |
| Parfitt, J | 1 |
| Larsen, L | 1 |
| Smith, RA | 1 |
| Murphy, MP | 1 |
| Schimmer, AD | 1 |
| Kelley, SO | 2 |
| Jean, SR | 1 |
| Le Guillou, M | 1 |
| Richard, F | 1 |
| L'Hénaff, F | 1 |
| Ferriere, JM | 1 |
| Durand, J | 1 |
| Lacert, P | 1 |
| Küss, R | 1 |
| Fernandes, RS | 1 |
| Cotter, TG | 1 |
| Pratt, RA | 1 |
| Di Chiro, G | 1 |
| Weed, JC | 1 |
| Egawa, H | 1 |
| Mori, K | 1 |
| Mitsuhashi, S | 1 |
| Bannai, K | 1 |
| Asano, K | 1 |
| Ozawa, K | 1 |
| Voigtmann, R | 1 |
| Topp, JR | 1 |
| Hart, GD | 1 |
| Fayemi, AO | 1 |
| Williams, J | 1 |
| Cuttner, J | 1 |
| Johnson, JR | 2 |
| McGovern, VJ | 2 |
| May, J | 1 |
| Lauer, C | 1 |
| Owen, LN | 1 |
| Kelly, DF | 1 |
| Porter, P | 1 |
12 other studies available for chlorambucil and Necrosis
| Article | Year |
|---|---|
Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell-Penetrating Peptides; Chlorambucil; Cros | 2013 |
Structural modifications of mitochondria-targeted chlorambucil alter cell death mechanism but preserve MDR evasion.
Topics: Alkylating Agents; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Nucleus; Cel | 2014 |
Bilateral ureteral necrosis in a child with dermatomyositis.
Topics: Adrenal Cortex Hormones; Child; Chlorambucil; Dermatomyositis; Dilatation; Female; Humans; Necrosis; | 1980 |
Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death.
Topics: Alkylating Agents; Apoptosis; Camptothecin; Cell Death; Cell Line; Chlorambucil; Dactinomycin; DNA; | 1994 |
Cerebral necrosis following irradiation and chemotherapy for metastatic choriocarcinoma.
Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Brain Neoplasms; Chlorambucil; Choriocarcinoma; | 1977 |
Effects of intraarterial chemotherapy using the new lipophilic anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol on Walker 256 carcinosarcoma in Wistar rats--a preliminary report.
Topics: Animals; Antineoplastic Agents; Carcinosarcoma; Chlorambucil; Dose-Response Relationship, Drug; Estr | 1990 |
[Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neopl | 1989 |
Widespread necrotizing arteritis in rheumatoid arthritis: report of a patient who survived.
Topics: Adrenocorticotropic Hormone; Arteritis; Arthritis, Rheumatoid; Biopsy; Chlorambucil; Diabetes Mellit | 1967 |
Systemic Weber-Christian disease and thrombocythemia terminating in reticulum-cell sarcoma.
Topics: Adipose Tissue; Adult; Agammaglobulinemia; Arteritis; Arthritis, Rheumatoid; Autopsy; Blood Platelet | 1974 |
Focal necrotizing glomerulonephritis: treatment with prednisone and chlorambucil.
Topics: Adult; Aged; Biopsy; Child; Chlorambucil; Female; Follow-Up Studies; Glomerulonephritis; Humans; Kid | 1973 |
Focal necrotizing glomerulonephritis.
Topics: Adolescent; Adult; Aged; Anti-Glomerular Basement Membrane Disease; Biopsy; Blood Urea Nitrogen; Cap | 1973 |
The effect of N.N.-di-(2 chloroethyl)p-amino phenylbutyric acid (chlorambucil) on sheep.
Topics: Animals; Antibody Formation; Blood Cell Count; Blood Cells; Blood Protein Electrophoresis; Blood Pro | 1966 |