Page last updated: 2024-08-07 17:27:01
Histamine H3 receptor
[no definition available]
Synonyms
H3R;
HH3R
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-methylhistamine | Cavia porcellus (domestic guinea pig) | EC50 | 1.5849 | 1 | 1 |
| pitolisant | Cavia porcellus (domestic guinea pig) | EC50 | 0.0015 | 1 | 1 |
| methylhistaprodifen | Cavia porcellus (domestic guinea pig) | Kd | 1.5849 | 1 | 5 |
| histaprodifen | Cavia porcellus (domestic guinea pig) | Kd | 1.5849 | 1 | 5 |
Drugs with Other Measurements
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
From histamine to imidazolylalkyl-sulfonamides: the design of a novel series of histamine H3-receptor antagonists.Bioorganic & medicinal chemistry letters, , Jul-05, Volume: 9, Issue:13, 1999
A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995
A new potent and selective histamine H3 receptor agonist, 4-(1H-imidazol-4-ylmethyl)piperidine.Journal of medicinal chemistry, , Feb-04, Volume: 37, Issue:3, 1994
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
A new potent and selective histamine H3 receptor agonist, 4-(1H-imidazol-4-ylmethyl)piperidine.Journal of medicinal chemistry, , Feb-04, Volume: 37, Issue:3, 1994
Design, synthesis, and MedChemComm, , Feb-01, Volume: 10, Issue:2, 2019
Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine.Bioorganic & medicinal chemistry letters, , Jun-16, Volume: 13, Issue:12, 2003
4-[(1H-imidazol-4-yl) methyl] benzamidines and benzylamidines: novel antagonists of the histamine H3 receptor.Bioorganic & medicinal chemistry letters, , Aug-18, Volume: 8, Issue:16, 1998
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999