Page last updated: 2024-08-07 18:50:24
G-protein coupled receptor 35
A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97]
Synonyms
Kynurenic acid receptor;
KYNA receptor
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (90.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Compounds (28)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| pqq cofactor | Homo sapiens (human) | IC50 | 0.3060 | 2 | 2 |
| cromolyn | Homo sapiens (human) | Ki | 2.3400 | 1 | 1 |
| furosemide | Homo sapiens (human) | Ki | 3.2700 | 1 | 1 |
| kynurenic acid | Homo sapiens (human) | IC50 | 39.0000 | 1 | 1 |
| kynurenic acid | Homo sapiens (human) | Ki | 137.0000 | 1 | 1 |
| lapachol | Homo sapiens (human) | IC50 | 4.6600 | 1 | 1 |
| niflumic acid | Homo sapiens (human) | IC50 | 1.2800 | 1 | 1 |
| niflumic acid | Homo sapiens (human) | Ki | 3.6100 | 1 | 1 |
| pamoic acid | Homo sapiens (human) | Ki | 0.0115 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| lobaric acid | Homo sapiens (human) | IC50 | 4.5400 | 1 | 1 |
| firefly luciferin | Homo sapiens (human) | Ki | 9.8600 | 1 | 1 |
| Thieno[3,2-b]thiophene-2-carboxylic acid | Homo sapiens (human) | IC50 | 57.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 15.4000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| morin | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 2.1200 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| alpha-cyano-4-hydroxycinnamic acid | Homo sapiens (human) | IC50 | 30.4000 | 1 | 1 |
| cid-2745687 | Homo sapiens (human) | IC50 | 3.7247 | 3 | 3 |
| cid-2745687 | Homo sapiens (human) | Ki | 0.0422 | 1 | 1 |
| dicumarol | Homo sapiens (human) | Ki | 0.0390 | 1 | 1 |
| zaprinast | Homo sapiens (human) | IC50 | 3.2470 | 4 | 4 |
| zaprinast | Homo sapiens (human) | Ki | 0.4010 | 1 | 1 |
| hematein | Homo sapiens (human) | IC50 | 30.4000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| pqq cofactor | Homo sapiens (human) | EC50 | 0.0710 | 1 | 1 |
| amlexanox | Homo sapiens (human) | EC50 | 4.0000 | 1 | 1 |
| cromolyn | Homo sapiens (human) | EC50 | 1.9455 | 4 | 4 |
| furosemide | Homo sapiens (human) | EC50 | 8.7000 | 2 | 2 |
| kynurenic acid | Homo sapiens (human) | EC50 | 199.8000 | 9 | 9 |
| lapachol | Homo sapiens (human) | EC50 | 25.3700 | 2 | 2 |
| niflumic acid | Homo sapiens (human) | EC50 | 17.6520 | 5 | 5 |
| pamoic acid | Homo sapiens (human) | EC50 | 0.3223 | 7 | 7 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | EC50 | 92.2600 | 1 | 1 |
| cromolyn sodium | Homo sapiens (human) | EC50 | 1.2600 | 1 | 1 |
| doxantrazole | Homo sapiens (human) | EC50 | 3.4000 | 1 | 1 |
| lodoxamide | Homo sapiens (human) | EC50 | 4.0000 | 1 | 1 |
| bufrolin | Homo sapiens (human) | EC50 | 0.0130 | 1 | 1 |
| lobaric acid | Homo sapiens (human) | EC50 | 9.9950 | 2 | 2 |
| firefly luciferin | Homo sapiens (human) | EC50 | 144.9500 | 2 | 2 |
| 5,6-dihydroxy-2-indolylcarboxylic acid | Homo sapiens (human) | EC50 | 23.4000 | 2 | 2 |
| Thieno[3,2-b]thiophene-2-carboxylic acid | Homo sapiens (human) | EC50 | 42.4000 | 1 | 1 |
| quercetin | Homo sapiens (human) | EC50 | 6.9750 | 2 | 2 |
| luteolin | Homo sapiens (human) | EC50 | 5.2200 | 2 | 2 |
| baicalein | Homo sapiens (human) | EC50 | 16.5000 | 2 | 2 |
| morin | Homo sapiens (human) | EC50 | 6.2650 | 2 | 2 |
| myricetin | Homo sapiens (human) | EC50 | 8.8600 | 2 | 2 |
| ellagic acid | Homo sapiens (human) | EC50 | 1.5350 | 2 | 2 |
| alpha-cyano-4-hydroxycinnamic acid | Homo sapiens (human) | EC50 | 40.2500 | 2 | 2 |
| dicumarol | Homo sapiens (human) | EC50 | 4.1267 | 3 | 3 |
| zaprinast | Homo sapiens (human) | EC50 | 2.0763 | 18 | 18 |
| hematein | Homo sapiens (human) | EC50 | 7.9000 | 2 | 2 |
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| C-X-C chemokine receptor activity | molecular function | Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:signaling, PMID:8662823] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| positive regulation of cytosolic calcium ion concentration | biological process | Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai] |
| chemokine-mediated signaling pathway | biological process | The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling] |
| negative regulation of voltage-gated calcium channel activity | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie] |
| negative regulation of neuronal action potential | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. [GO_REF:0000058, GOC:TermGenie, PMID:25126967] |
| positive regulation of Rho protein signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. [GOC:bf] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |