Proteins > G-protein coupled receptor 35
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G-protein coupled receptor 35
A G-protein coupled receptor 35 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9HC97]
Synonyms
Kynurenic acid receptor;
KYNA receptor
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (90.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Compounds (28)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle.Journal of medicinal chemistry, , 03-11, Volume: 64, Issue:5, 2021
Structure-activity relationships of benzothiazole GPR35 antagonists.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 27, Issue:3, 2017
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Jun-27, Volume: 56, Issue:12, 2013
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.ACS medicinal chemistry letters, , Feb-09, Volume: 3, Issue:2, 2012
Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle.Journal of medicinal chemistry, , 03-11, Volume: 64, Issue:5, 2021
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Jun-27, Volume: 56, Issue:12, 2013
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
SAR Studies of ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle.Journal of medicinal chemistry, , 03-11, Volume: 64, Issue:5, 2021
SAR Studies of ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.Journal of medicinal chemistry, , 01-12, Volume: 60, Issue:1, 2017
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.Journal of medicinal chemistry, , Jun-27, Volume: 56, Issue:12, 2013
Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues.ACS medicinal chemistry letters, , Jul-12, Volume: 3, Issue:7, 2012
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 22, Issue:12, 2012
Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.ACS medicinal chemistry letters, , Feb-09, Volume: 3, Issue:2, 2012
Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.Journal of medicinal chemistry, , Oct-27, Volume: 54, Issue:20, 2011
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| C-X-C chemokine receptor activity | molecular function | Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:signaling, PMID:8662823] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|
| cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:dph, GOC:jl, GOC:mah] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| positive regulation of cytosolic calcium ion concentration | biological process | Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai] |
| chemokine-mediated signaling pathway | biological process | The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling] |
| negative regulation of voltage-gated calcium channel activity | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie] |
| negative regulation of neuronal action potential | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. [GO_REF:0000058, GOC:TermGenie, PMID:25126967] |
| positive regulation of Rho protein signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. [GOC:bf] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |