A tyrosine-protein phosphatase non-receptor type 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35236]
EC 3.1.3.48;
Hematopoietic protein-tyrosine phosphatase;
HEPTP;
Protein-tyrosine phosphatase LC-PTP
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| glycyrrhetinic acid | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| imperatorin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| rac-glycerol 1-monodecanoate | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| celastrol | Homo sapiens (human) | IC50 | 75.7000 | 1 | 1 |
| nsc-89199 | Homo sapiens (human) | IC50 | 152.7000 | 1 | 1 |
| cefsulodin | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| illudalic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| linoleic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| stigmasterol 3-o-beta-d-glucopyranoside | Homo sapiens (human) | IC50 | 82.5000 | 1 | 1 |
| 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| non-membrane spanning protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cytoplasmic side of plasma membrane | cellular component | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| microtubule cytoskeleton | cellular component | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172] |
| mitotic spindle | cellular component | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| MAPK cascade | biological process | An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267] |
| protein dephosphorylation | biological process | The process of removing one or more phosphoric residues from a protein. [GOC:hb] |