Page last updated: 2024-08-07 16:31:19
Delta-type opioid receptor
A delta-type opioid receptor that is encoded in the genome of rat. [OMA:P33533, PRO:DNx]
Synonyms
D-OR-1;
DOR-1;
Opioid receptor A
Research
Bioassay Publications (129)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 19 (14.73) | 18.7374 |
| 1990's | 33 (25.58) | 18.2507 |
| 2000's | 41 (31.78) | 29.6817 |
| 2010's | 29 (22.48) | 24.3611 |
| 2020's | 7 (5.43) | 2.80 |
Compounds (132)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bremazocine | Rattus norvegicus (Norway rat) | IC50 | 0.0015 | 1 | 2 |
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0069 | 2 | 2 |
| aurintricarboxylic acid | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 1 | 1 |
| celecoxib | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| dichlorphenamide | Rattus norvegicus (Norway rat) | Ki | 0.0380 | 1 | 1 |
| ethoxzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 2 | 2 |
| fentanyl | Rattus norvegicus (Norway rat) | IC50 | 0.0122 | 4 | 5 |
| fentanyl | Rattus norvegicus (Norway rat) | Ki | 0.6117 | 2 | 3 |
| haloperidol | Rattus norvegicus (Norway rat) | Ki | 7.0700 | 2 | 3 |
| hydrochlorothiazide | Rattus norvegicus (Norway rat) | Ki | 0.2900 | 1 | 1 |
| ifenprodil | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| loperamide | Rattus norvegicus (Norway rat) | Ki | 0.0501 | 1 | 1 |
| mafenide | Rattus norvegicus (Norway rat) | Ki | 0.1700 | 1 | 1 |
| methazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0082 | 2 | 2 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| prazosin | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| rolipram | Rattus norvegicus (Norway rat) | IC50 | 1.5000 | 1 | 1 |
| saccharin | Rattus norvegicus (Norway rat) | Ki | 5.9590 | 1 | 1 |
| sulfanilamide | Rattus norvegicus (Norway rat) | Ki | 0.2400 | 1 | 1 |
| sulpiride | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 1 | 1 |
| sulthiame | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 1 | 1 |
| zonisamide | Rattus norvegicus (Norway rat) | Ki | 0.0278 | 2 | 2 |
| 4-toluenesulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.3200 | 1 | 1 |
| 1,3-ditolylguanidine | Rattus norvegicus (Norway rat) | Ki | 3.9500 | 1 | 1 |
| fluorodeoxyuridylate | Rattus norvegicus (Norway rat) | Ki | 0.0140 | 1 | 1 |
| carzenide | Rattus norvegicus (Norway rat) | Ki | 0.0460 | 1 | 1 |
| ketobemidone | Rattus norvegicus (Norway rat) | IC50 | 7.0000 | 1 | 1 |
| Berberine chloride (TN) | Rattus norvegicus (Norway rat) | IC50 | 18.2100 | 1 | 1 |
| etonitazene | Rattus norvegicus (Norway rat) | Ki | 0.5003 | 2 | 4 |
| benzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 1 | 1 |
| sufentanil | Rattus norvegicus (Norway rat) | IC50 | 0.0023 | 1 | 1 |
| carfentanil | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 2 | 3 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0750 | 1 | 1 |
| dibenzthione | Rattus norvegicus (Norway rat) | IC50 | 28.6000 | 1 | 2 |
| disulphane | Rattus norvegicus (Norway rat) | Ki | 0.0460 | 1 | 1 |
| brinzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0030 | 1 | 1 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0600 | 1 | 1 |
| nicotine | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| bromodeoxyuridylate | Rattus norvegicus (Norway rat) | Ki | 1.4000 | 1 | 1 |
| enkephalin, d-penicillamine (2,5)- | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 1 | 1 |
| enkephalin, ser(2), leu(5), thr(6)- | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 1 | 1 |
| bw 373u86 | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 2 | 3 |
| bw 373u86 | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 2 | 4 |
| marimastat | Rattus norvegicus (Norway rat) | IC50 | 0.0031 | 1 | 1 |
| morphiceptin | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| valdecoxib | Rattus norvegicus (Norway rat) | Ki | 0.0430 | 1 | 1 |
| 2-chloro-n(6)cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.2370 | 1 | 1 |
| 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide | Rattus norvegicus (Norway rat) | IC50 | 0.0879 | 3 | 5 |
| 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 6 | 8 |
| methotrexate | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| tyrosyl-seryl(o-tert-butyl)-glycyl-phenylalanyl-leucyl-threonine | Rattus norvegicus (Norway rat) | Ki | 0.0061 | 1 | 1 |
| 5-nitro-2'-deoxyuridine 5'-monophosphate | Rattus norvegicus (Norway rat) | Ki | 0.0290 | 1 | 1 |
| enkephalin, pen(2,5)-4-chloro-phe(4)- | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| 5-trifluoromethyl-2'-deoxyuridylic acid | Rattus norvegicus (Norway rat) | Ki | 0.0390 | 1 | 1 |
| 4-(2-aminoethyl)benzenesulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.1600 | 1 | 1 |
| varenicline | Rattus norvegicus (Norway rat) | Ki | 0.0940 | 1 | 1 |
| deltorphin ii, ile(5,6)- | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 4 | 5 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 1 |
| enkephalin, methionine | Rattus norvegicus (Norway rat) | IC50 | 0.1290 | 2 | 2 |
| enkephalin, methionine | Rattus norvegicus (Norway rat) | Ki | 0.0073 | 1 | 1 |
| 5-iodo-2'-deoxyuridine 5'-monophosphate | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| enkephalin, leucine | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 4 | 4 |
| etorphine | Rattus norvegicus (Norway rat) | IC50 | 0.0074 | 1 | 2 |
| etorphine | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| n(6)-cyclopentyladenosine | Rattus norvegicus (Norway rat) | Ki | 0.0970 | 1 | 1 |
| maraviroc | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| deltorphin | Rattus norvegicus (Norway rat) | Ki | 0.0836 | 3 | 7 |
| u-50488 | Rattus norvegicus (Norway rat) | IC50 | 8.7167 | 2 | 3 |
| u-50488 | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| benzene-1-3-disulfonamide | Rattus norvegicus (Norway rat) | Ki | 0.0080 | 1 | 1 |
| dorzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 1 | 1 |
| nalorphine | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 2 | 2 |
| naloxone | Rattus norvegicus (Norway rat) | IC50 | 0.0219 | 4 | 6 |
| naloxone | Rattus norvegicus (Norway rat) | Ki | 0.0527 | 2 | 2 |
| oxycodone | Rattus norvegicus (Norway rat) | Ki | 1.0870 | 1 | 1 |
| oxymorphone | Rattus norvegicus (Norway rat) | Ki | 0.0805 | 1 | 1 |
| topiramate | Rattus norvegicus (Norway rat) | Ki | 0.0177 | 2 | 2 |
| morphine | Rattus norvegicus (Norway rat) | IC50 | 0.2278 | 11 | 16 |
| morphine | Rattus norvegicus (Norway rat) | Ki | 0.1693 | 13 | 15 |
| 7-benzylidenenaltrexone | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 2 | 2 |
| endomorphin 1 | Rattus norvegicus (Norway rat) | Ki | 4.2847 | 6 | 6 |
| endomorphin 2 | Rattus norvegicus (Norway rat) | Ki | 8.0385 | 11 | 11 |
| fosbretabulin | Rattus norvegicus (Norway rat) | IC50 | 0.8100 | 1 | 1 |
| levallorphan | Rattus norvegicus (Norway rat) | IC50 | 0.0008 | 1 | 2 |
| naltrexone | Rattus norvegicus (Norway rat) | IC50 | 0.0063 | 3 | 5 |
| naltrexone | Rattus norvegicus (Norway rat) | Ki | 0.0377 | 7 | 10 |
| enkephalin, ala(2)-mephe(4)-gly(5)- | Rattus norvegicus (Norway rat) | Ki | 3.2577 | 3 | 4 |
| norbinaltorphimine | Rattus norvegicus (Norway rat) | Ki | 0.0652 | 3 | 6 |
| dermorphin | Rattus norvegicus (Norway rat) | Ki | 0.1340 | 1 | 2 |
| 6 beta-hydroxynaltrexone | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 2 |
| 14-methoxymetopon | Rattus norvegicus (Norway rat) | Ki | 0.0271 | 2 | 2 |
| naltrindole | Rattus norvegicus (Norway rat) | Ki | 0.0019 | 14 | 16 |
| cyprodime | Rattus norvegicus (Norway rat) | IC50 | 0.0472 | 1 | 2 |
| cyprodime | Rattus norvegicus (Norway rat) | Ki | 0.4169 | 1 | 1 |
| 7-benzylidenenaltrexone | Rattus norvegicus (Norway rat) | Ki | 0.0023 | 2 | 2 |
| 3,4-dichloro-n-methyl-n-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide, (trans)-(-)-isomer | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
| enkephalin, leucine-2-alanine | Rattus norvegicus (Norway rat) | IC50 | 0.0017 | 2 | 4 |
| enkephalin, leucine-2-alanine | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 2 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| 17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan | Rattus norvegicus (Norway rat) | Ki | 0.0355 | 2 | 2 |
| ly 255582 | Rattus norvegicus (Norway rat) | Ki | 0.1321 | 2 | 3 |
| bibr 1532 | Rattus norvegicus (Norway rat) | IC50 | 3.6000 | 1 | 1 |
| tan 67 | Rattus norvegicus (Norway rat) | Ki | 0.0014 | 1 | 1 |
| deltorphin i, ala(2)- | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| deltorphin i, ala(2)- | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 5 | 9 |
| 8-carboxamidocyclazocine | Rattus norvegicus (Norway rat) | Ki | 0.0083 | 1 | 1 |
| ar c155858 | Rattus norvegicus (Norway rat) | IC50 | 23.0000 | 1 | 1 |
| ufp-502 | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 2 | 2 |
| dynorphin a (1-11)-amide | Rattus norvegicus (Norway rat) | IC50 | 0.0255 | 1 | 2 |
| h-dmt-tic-gly-nh-bzl | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 2 | 2 |
| eluxadoline | Rattus norvegicus (Norway rat) | Ki | 0.0013 | 1 | 1 |
| ki 8751 | Rattus norvegicus (Norway rat) | IC50 | 2.4000 | 1 | 1 |
| sazetidine-a | Rattus norvegicus (Norway rat) | Ki | 0.2100 | 1 | 1 |
| 14-o-methyloxymorphone | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 1 | 1 |
| gsk188909 | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 1 |
| somatostatin | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 2 |
| 5-chloro-2'-deoxyuridine 5'-triphosphate | Rattus norvegicus (Norway rat) | Ki | 0.1900 | 1 | 1 |
| acid blue 25 | Rattus norvegicus (Norway rat) | IC50 | 2.7900 | 1 | 1 |
| sgi 1776 | Rattus norvegicus (Norway rat) | IC50 | 0.0070 | 1 | 1 |
| ici 174865 | Rattus norvegicus (Norway rat) | IC50 | 18.9000 | 1 | 1 |
| Benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]amino]pentan-2-yl]amino]-1-oxobutan-2-yl]carbamate | Rattus norvegicus (Norway rat) | Ki | 2.2000 | 1 | 1 |
| 4-hydroxy-1-(2-methylpropyl)-2-oxo-N-(2-sulfamoylphenyl)-3-quinolinecarboxamide | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 1 |
| pyrvinium pamoate | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| pacidamycin d | Rattus norvegicus (Norway rat) | IC50 | 0.0220 | 1 | 1 |
| sildenafil | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.Journal of medicinal chemistry, , Apr-28, Volume: 38, Issue:9, 1995
Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Potential affinity labels for the opiate receptor based on fentanyl and related compounds.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
Synthesis and stereochemistry of 7-phenyl-2-propionanilidobenzo[a]quinolizidine derivatives. Structural probes of fentanyl analgesics.Journal of medicinal chemistry, , Volume: 24, Issue:1, 1981
(+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.Journal of medicinal chemistry, , Jun-24, Volume: 37, Issue:13, 1994
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.Journal of medicinal chemistry, , Apr-19, Volume: 50, Issue:8, 2007
3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.Journal of medicinal chemistry, , Feb-13, Volume: 46, Issue:4, 2003
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.Journal of medicinal chemistry, , Mar-15, Volume: 44, Issue:6, 2001
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.Journal of medicinal chemistry, , Nov-19, Volume: 41, Issue:24, 1998
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Synthesis of 8-aminomorphans with high KOR affinity.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties.Journal of medicinal chemistry, , Dec-10, Volume: 52, Issue:23, 2009
Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.Journal of medicinal chemistry, , Apr-19, Volume: 50, Issue:8, 2007
Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.Journal of medicinal chemistry, , Mar-15, Volume: 44, Issue:6, 2001
4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.Bioorganic & medicinal chemistry letters, , Jun-05, Volume: 10, Issue:11, 2000
Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.Journal of medicinal chemistry, , Nov-19, Volume: 41, Issue:24, 1998
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)Journal of medicinal chemistry, , Feb-28, Volume: 40, Issue:5, 1997
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.Bioorganic & medicinal chemistry letters, , Apr-17, Volume: 10, Issue:8, 2000
Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997
Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 23, Issue:19, 2013
Conformationally restricted deltorphin analogues.Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity.Journal of medicinal chemistry, , Apr-19, Volume: 50, Issue:8, 2007
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996
Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.Journal of medicinal chemistry, , Apr-03, Volume: 35, Issue:7, 1992
Conformationally restricted deltorphin analogues.Journal of medicinal chemistry, , Oct-16, Volume: 35, Issue:21, 1992
Function of negative charge in the "address domain" of deltorphins.Journal of medicinal chemistry, , Volume: 34, Issue:4, 1991
Evaluation of N-substitution in 6,7-benzomorphan compounds.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Non-peptide ligands for opioid receptors. Design of kappa-specific agonists.Journal of medicinal chemistry, , Jun-25, Volume: 36, Issue:13, 1993
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Synthesis of 8-aminomorphans with high KOR affinity.European journal of medicinal chemistry, , Feb-15, Volume: 230, 2022
[no title available]Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.Journal of medicinal chemistry, , Jun-26, Volume: 35, Issue:13, 1992
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.Journal of medicinal chemistry, , Volume: 29, Issue:4, 1986
Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.Journal of medicinal chemistry, , Volume: 26, Issue:1, 1983
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics.Journal of medicinal chemistry, , Volume: 21, Issue:1, 1978
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Discovery of an Journal of medicinal chemistry, , 08-26, Volume: 64, Issue:16, 2021
[no title available]Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
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