Proteins > Phospholipase A2, major isoenzyme
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Phospholipase A2, major isoenzyme
A phospholipase A2 that is encoded in the genome of pig. [OMA:P00592, PRO:DNx]
Synonyms
EC 3.1.1.4;
Group IB phospholipase A2;
Phosphatidylcholine 2-acylhydrolase 1B
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenidone | Sus scrofa (pig) | Activity | 300.0000 | 1 | 1 |
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.Journal of medicinal chemistry, , 04-08, Volume: 64, Issue:7, 2021
Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.Journal of medicinal chemistry, , Dec-20, Volume: 39, Issue:26, 1996
Design of new potent and selective secretory phospholipase A(2) inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/diBioorganic & medicinal chemistry, , May-15, Volume: 18, Issue:10, 2010
Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines.Bioorganic & medicinal chemistry, , Feb-01, Volume: 16, Issue:3, 2008
Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007