A prolyl endopeptidase that is encoded in the genome of rat. [OMA:O70196, PRO:DNx]
PE;
EC 3.4.21.26;
Post-proline cleaving enzyme;
rPop
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| acetazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| dichlorphenamide | Rattus norvegicus (Norway rat) | Ki | 0.6300 | 1 | 1 |
| ethoxzolamide | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| gossypol | Rattus norvegicus (Norway rat) | IC50 | 0.2800 | 1 | 2 |
| methazolamide | Rattus norvegicus (Norway rat) | Ki | 0.0650 | 1 | 1 |
| zonisamide | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| n-benzyloxycarbonylprolylprolinal | Rattus norvegicus (Norway rat) | IC50 | 0.0540 | 1 | 1 |
| jtp 4819 | Rattus norvegicus (Norway rat) | IC50 | 0.0001 | 1 | 1 |
| n-(n-(phenyl)butyryl-l-prolyl)pyrrolidine | Rattus norvegicus (Norway rat) | IC50 | 0.0072 | 1 | 1 |
| topiramate | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 1 |
| (2s,3as,7as)-1-(((r,r)-2-phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1h-indole | Rattus norvegicus (Norway rat) | Ki | 0.0013 | 1 | 1 |
| kyp 2047 | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 1 | 1 |