Proteins > 5-hydroxytryptamine receptor 5A
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5-hydroxytryptamine receptor 5A
A 5-hydroxytryptamine receptor 5A that is encoded in the genome of rat. [OMA:P35364, PRO:DNx]
Synonyms
5-HT-5A;
5-HT5A;
REC17;
Serotonin receptor 5A
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (47)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amitriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| clomipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 1 |
| desipramine | Rattus norvegicus (Norway rat) | IC50 | 0.3500 | 1 | 1 |
| doxepin | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| imipramine | Rattus norvegicus (Norway rat) | IC50 | 0.0440 | 1 | 1 |
| mianserin | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| nortriptyline | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| ondansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| apomorphine | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| pergolide | Rattus norvegicus (Norway rat) | IC50 | 0.3850 | 1 | 1 |
| quinpirole | Rattus norvegicus (Norway rat) | Ki | 1.5000 | 1 | 1 |
| etisulergine | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 2 | 2 |
| cocaine | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| quinagolide | Rattus norvegicus (Norway rat) | IC50 | 5.6000 | 2 | 4 |
| preclamol | Rattus norvegicus (Norway rat) | Ki | 2.1000 | 1 | 1 |
| cilansetron | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| ms-245 | Rattus norvegicus (Norway rat) | Ki | 5.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phenethylamine | Rattus norvegicus (Norway rat) | Kd | 5.4954 | 2 | 4 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.0324 | 1 | 1 |
| 3,4-methylenedioxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.3548 | 1 | 2 |
| amphetamine | Rattus norvegicus (Norway rat) | Kd | 5.3703 | 3 | 5 |
| mescaline | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| o-methyltyramine | Rattus norvegicus (Norway rat) | Kd | 7.9433 | 1 | 2 |
| tyramine | Rattus norvegicus (Norway rat) | Kd | 8.5114 | 1 | 2 |
| dextroamphetamine | Rattus norvegicus (Norway rat) | Kd | 4.4668 | 1 | 2 |
| n,n-dimethyltryptamine | Rattus norvegicus (Norway rat) | Kd | 1.0000 | 1 | 1 |
| dimethoxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 4.3652 | 1 | 2 |
| 3,4-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 3.5481 | 1 | 2 |
| 3-phenylpropylamine | Rattus norvegicus (Norway rat) | Kd | 11.7490 | 1 | 2 |
| 2,5-dimethoxy-4-ethylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0661 | 2 | 3 |
| 2,4,5-trimethoxyphenylisopropylamine | Rattus norvegicus (Norway rat) | Kd | 0.1549 | 2 | 3 |
| 4-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 7.0795 | 2 | 3 |
| l-amphetamine | Rattus norvegicus (Norway rat) | Kd | 6.9183 | 1 | 2 |
| 2-aminotetralin | Rattus norvegicus (Norway rat) | Kd | 2.4547 | 1 | 2 |
| 2,5-dimethoxy-4-bromoamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0447 | 2 | 3 |
| cathinone | Rattus norvegicus (Norway rat) | Kd | 3.0200 | 1 | 2 |
| 2,5-dimethoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.1479 | 2 | 3 |
| 3,4-methylenedioxyphenethylamine | Rattus norvegicus (Norway rat) | Kd | 0.7943 | 1 | 2 |
| 3-methoxy-4-hydroxyphenylethylamine | Rattus norvegicus (Norway rat) | Kd | 1.2882 | 1 | 2 |
| 2-(2,5-dimethoxyphenyl)ethanamine | Rattus norvegicus (Norway rat) | Kd | 0.1412 | 1 | 2 |
| 2,5-dimethoxy-4-methylamphetamine | Rattus norvegicus (Norway rat) | Kd | 0.0753 | 2 | 3 |
| 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane | Rattus norvegicus (Norway rat) | Kd | 0.0851 | 1 | 1 |
| 3-methoxyamphetamine | Rattus norvegicus (Norway rat) | Kd | 1.1749 | 3 | 4 |
| n-desmethylmethoxyphenamine | Rattus norvegicus (Norway rat) | Kd | 2.8840 | 2 | 3 |
| 4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.0234 | 1 | 1 |
| 2,5-dimethoxy-4-bromoamphetamine, (s)-isomer | Rattus norvegicus (Norway rat) | Kd | 0.1175 | 1 | 1 |
| vu0357017 | Rattus norvegicus (Norway rat) | EC50 | 95.7200 | 1 | 0 |
Serotonin receptor affinity of cathinone and related analogues.Journal of medicinal chemistry, , Volume: 25, Issue:4, 1982
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.Journal of medicinal chemistry, , Volume: 25, Issue:10, 1982
Serotonin receptor affinities of psychoactive phenalkylamine analogues.Journal of medicinal chemistry, , Volume: 23, Issue:3, 1980
Studies on several 7-substituted N,N-dimethyltryptamines.Journal of medicinal chemistry, , Volume: 23, Issue:11, 1980
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.Journal of medicinal chemistry, , Volume: 28, Issue:10, 1985
Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985