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Acetylcholinesterase
An acetylcholinesterase that is encoded in the genome of Tetronarce californica. [PRO:DAN, UniProtKB:P04058]
Synonyms
AChE;
EC 3.1.1.7
Research
Bioassay Publications (25)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 14 (56.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
Compounds (22)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| isoflurophate | Tetronarce californica (Pacific electric ray) | Kd | 70.0000 | 1 | 1 |
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.Journal of the American Chemical Society, , Jan-15, Volume: 125, Issue:2, 2003
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.Biochemistry, , Sep-03, Volume: 41, Issue:35, 2002
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 30, Issue:3, 2020
[no title available]Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
Synthesis and cholinesterase inhibition of cativic acid derivatives.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.Bioorganic & medicinal chemistry, , Jul-01, Volume: 22, Issue:13, 2014
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 21, Issue:6, 2006
Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.Bioorganic & medicinal chemistry letters, , May-19, Volume: 13, Issue:10, 2003
A structure-based design approach to the development of novel, reversible AChE inhibitors.Journal of medicinal chemistry, , Sep-27, Volume: 44, Issue:20, 2001
Aminopyridazines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series.Bioorganic & medicinal chemistry, , Volume: 6, Issue:10, 1998
Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and β-secretase inhibition activities.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Aminopyridazines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Feb-25, Volume: 42, Issue:4, 1999
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases.Bioorganic chemistry, , Volume: 68, 2016
Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.Bioorganic & medicinal chemistry, , Jul-01, Volume: 22, Issue:13, 2014
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp.Bioorganic & medicinal chemistry, , Jul-01, Volume: 16, Issue:13, 2008
Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 17, Issue:8, 2007
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids.Journal of enzyme inhibition and medicinal chemistry, , Volume: 21, Issue:6, 2006
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.Journal of the American Chemical Society, , Dec-01, Volume: 126, Issue:47, 2004
Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.Bioorganic & medicinal chemistry letters, , May-19, Volume: 13, Issue:10, 2003
Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series.Bioorganic & medicinal chemistry, , Volume: 6, Issue:10, 1998