persin: isolated from the leaves of avocado (Persea americana); structure given in first source; RN given refers to compound with no isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 5283266 |
| CHEBI ID | 168336 |
| SCHEMBL ID | 897833 |
| MeSH ID | M0257892 |
| Synonym |
|---|
| 60640-59-7 |
| CHEBI:168336 |
| [(12z,15z)-2-hydroxy-4-oxohenicosa-12,15-dienyl] acetate |
| 1-acetoxy-2-hydroxy-12z,15z-heneicosadien-4-one |
| LMFA05000011 |
| (z,z)-1-(acetoxy)-2-hydroxy-12,15-heneicosadien-4-one |
| 1-acetoxy-2-hydroxy-heneicosa-12z,15z-dien-4-one |
| persin |
| 1-acetyloxy-2-hydroxy-12,15-heneicosadien-4-one |
| 12,15-heneicosadien-4-one, 1-(acetyloxy)-2-hydroxy- |
| (z,z)-1-acetyloxy-2-hydroxy-12,15-heneicosadien-4-one |
| SCHEMBL897833 |
| 2-hydroxy-4-oxo-12,15-heneicosadien-1-yl acetate |
| (z,z)-1-acetoxy-2-hydroxy-4-oxo-heneicosa-12,15-diene |
| Q633921 |
| DTXSID601027122 |
Persin is a plant toxin that displays synergistic cytotoxicity with tamoxifen in human breast cancer cell lines. The PersIn framework is a proposed approach for personalizing an evidence-based intervention.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The PersIn framework is a proposed approach for personalizing an evidence-based intervention to facilitate cultural responsiveness concurrent with fidelity to the original intervention, flexibility in individual implementation, and administration that is standardized, feasible, and replicable." | ( Personalizing PCIT for culturally diverse families: Outcomes from a pilot trial utilizing the PersIn framework. McCabe, K; Yeh, M; Zerr, A, 2022) | 1.42 |
| "Persin is a plant toxin that displays synergistic cytotoxicity with tamoxifen in human breast cancer cell lines. " | ( Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells. Biden, TJ; Boslem, E; Burgess, A; Butt, AJ; Gee, JM; McCloy, RA; Musgrove, EA; Nicholson, RI; Roberts, CG; Shelley, EJ; Sutherland, RL, 2013) | 2.07 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Persin has previously been isolated from avocado leaves and shown to have antifungal properties and to be toxic to silkworms." | ( Isolation and identification of a compound from avocado (Persea americana) leaves which causes necrosis of the acinar epithelium of the lactating mammary gland and the myocardium. MacLeod, JK; Ng, JC; Oelrichs, PB; Schäffeler, L; Seawright, AA; Ward, A, 1995) | 1.01 |
| Class | Description |
|---|---|
| long-chain fatty alcohol | A fatty alcohol with a chain length ranging from C13 to C22. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (70.10) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||