Solute carrier organic anion transporter family member 2B1

A solute carrier organic anion transporter family member 2B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94956]

Synonyms

Organic anion transporter B;
OATP-B;
Organic anion transporter polypeptide-related protein 2;
OATP-RP2;
OATPRP2;
Solute carrier family 21 member 9

Research

Bioassay Publications (11)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (45.45)	29.6817
2010's	6 (54.55)	24.3611
2020's	0 (0.00)	2.80

Compounds (21)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
hoe 33342	Homo sapiens (human)	IC50	51.0000	1	1
hoe 33342	Homo sapiens (human)	Ki	20.0000	1	1
indomethacin	Homo sapiens (human)	IC50	140.0000	1	1
indomethacin	Homo sapiens (human)	Ki	130.0000	1	1
sulfasalazine	Homo sapiens (human)	IC50	3.0000	1	1
sulfasalazine	Homo sapiens (human)	Ki	3.0000	1	1
silybin	Homo sapiens (human)	IC50	4.5000	1	1
pravastatin	Homo sapiens (human)	IC50	190.0000	1	1
pravastatin	Homo sapiens (human)	Ki	180.0000	1	1
atazanavir	Homo sapiens (human)	IC50	5.2000	1	1
atazanavir	Homo sapiens (human)	Ki	5.1000	1	1
erlotinib	Homo sapiens (human)	IC50	0.5500	1	1
erlotinib	Homo sapiens (human)	Ki	0.5300	1	1
scutellarin	Homo sapiens (human)	Ki	25.9000	1	1
ritonavir	Homo sapiens (human)	IC50	6.1000	1	1
ritonavir	Homo sapiens (human)	Ki	5.9000	1	1
l 660,711	Homo sapiens (human)	IC50	2.9000	1	1
l 660,711	Homo sapiens (human)	Ki	2.8000	1	1
cyclosporine	Homo sapiens (human)	IC50	37.0000	1	1
cyclosporine	Homo sapiens (human)	Ki	36.0000	1	1
fosbretabulin	Homo sapiens (human)	IC50	12.2700	1	1
rifamycin sv	Homo sapiens (human)	Ki	3.0000	1	1
rifampin	Homo sapiens (human)	IC50	65.0000	1	1
rifampin	Homo sapiens (human)	Ki	63.0000	1	1
amg531	Homo sapiens (human)	Ki	8.4800	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glyburide	Homo sapiens (human)	Km	6.2600	1	1
mesalamine	Homo sapiens (human)	Km	188.9000	1	1
sulfobromophthalein sodium	Homo sapiens (human)	Km	0.7000	1	1
taurocholic acid	Homo sapiens (human)	Km	71.8000	1	1
pravastatin	Homo sapiens (human)	Km	2,250.0000	1	1
atorvastatin	Homo sapiens (human)	Km	2.8400	1	1
scutellarin	Homo sapiens (human)	Km	43.0000	1	1
estrone sulfate	Homo sapiens (human)	Km	15.8140	5	5

Enables

This protein enables 5 target(s):

Target	Category	Definition
organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai]
prostaglandin transmembrane transporter activity	molecular function	Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai]
sodium-independent organic anion transmembrane transporter activity	molecular function	Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators]
transmembrane transporter activity	molecular function	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
bile acid transmembrane transporter activity	molecular function	Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
organic anion transport	biological process	The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai, GOC:krc]
prostaglandin transport	biological process	The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc]
heme catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl]
sodium-independent organic anion transport	biological process	The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators]
transmembrane transport	biological process	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
bile acid and bile salt transport	biological process	The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]