Proteins > 5-hydroxytryptamine receptor 3A
Page last updated: 2024-08-07 16:15:36
5-hydroxytryptamine receptor 3A
A 5-hydroxytryptamine receptor 3A that is encoded in the genome of mouse. [OMA:P23979, PRO:DNx]
Synonyms
5-HT3-A;
5-HT3A;
5-hydroxytryptamine receptor 3;
5-HT-3;
5-HT3R;
Serotonin receptor 3A;
Serotonin-gated ion channel receptor
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 2-methyl-5-ht | Mus musculus (house mouse) | Ki | 1.4300 | 1 | 1 |
| haloperidol | Mus musculus (house mouse) | Ki | 10.0000 | 1 | 1 |
| metoclopramide | Mus musculus (house mouse) | Ki | 0.2000 | 1 | 2 |
| mianserin | Mus musculus (house mouse) | IC50 | 1.4125 | 1 | 1 |
| mianserin | Mus musculus (house mouse) | Ki | 0.2520 | 1 | 1 |
| ondansetron | Mus musculus (house mouse) | Ki | 0.0120 | 1 | 1 |
| quipazine | Mus musculus (house mouse) | Ki | 0.0087 | 1 | 1 |
| rizatriptan | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 1 |
| zacopride | Mus musculus (house mouse) | Ki | 0.0013 | 1 | 1 |
| tropisetron | Mus musculus (house mouse) | Ki | 0.0038 | 1 | 1 |
| naluzotan | Mus musculus (house mouse) | Ki | 5.0000 | 1 | 1 |
| clozapine | Mus musculus (house mouse) | Ki | 0.0320 | 1 | 1 |
Drugs with Activation Measurements
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990