Page last updated: 2024-08-01 11:22:43
mycolactone
Description
mycolactone: toxin from Mycobacterium ulcerans required for virulence [MeSH]
Mycolactone : no description available [CHeBI]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 5282079 |
| SCHEMBL ID | 1229472 |
| CHEBI ID | 31871 |
| MeSH ID | M0300994 |
Synonyms (10)
| Synonym |
|---|
| C12151 , |
| mycolactone |
| [(6s,7s,9e,12r)-12-[(e,2s,6r,7r,9r)-7,9-dihydroxy-4,6-dimethyldec-4-en-2-yl]-7,9-dimethyl-2-oxo-1-oxacyclododec-9-en-6-yl] (2e,4e,6e,8e,10e,12s,13s,15s)-12,13,15-trihydroxy-4,6,10-trimethylhexadeca-2,4,6,8,10-pentaenoate |
| AC1NQZGK , |
| 222050-77-3 |
| SCHEMBL1229472 |
| CHEBI:31871 |
| DTXSID10415207 |
| [(6s,7s,9e,12r)-12-[(e,1s,5r,6r,8r)-6,8-dihydroxy-1,3,5-trimethyl-non-3-enyl]-7,9-dimethyl-2-oxo-1-oxacyclododec-9-en-6-yl] (2e,4e,6e,8e,10e,12s,13s,15s)-12,13,15-trihydroxy-4,6,10-trimethyl-hexadeca-2,4,6,8,10-pentaenoate |
| Q6947140 |
Drug Classes (1)
| Class | Description |
|---|
| macrolide | A macrocyclic lactone with a ring of twelve or more members derived from a polyketide. |
Research
Studies (165)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.61) | 18.2507 |
| 2000's | 44 (26.67) | 29.6817 |
| 2010's | 86 (52.12) | 24.3611 |
| 2020's | 34 (20.61) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 1 (0.60%) | 5.53% |
| Reviews | 22 (13.17%) | 6.00% |
| Case Studies | 1 (0.60%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 143 (85.63%) | 84.16% |
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.PLoS pathogens, , Volume: 19, Issue:11, 2023
Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology.PLoS pathogens, , Volume: 16, Issue:12, 2020
Shaping mycolactone for therapeutic use against inflammatory disorders.Science translational medicine, , May-27, Volume: 7, Issue:289, 2015
Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer.The Lancet. Infectious diseases, , Volume: 9, Issue:11, 2009
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Transcriptional adaptation of Virulence, , Volume: 12, Issue:1, 2021
Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease.Journal of clinical microbiology, , Volume: 56, Issue:4, 2018
Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission.Microbes and infection, , Volume: 14, Issue:9, 2012
A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-16, Volume: 17, Issue:51, 2011
Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F.Infection and immunity, , Volume: 74, Issue:11, 2006
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.PLoS pathogens, , Volume: 11, Issue:7, 2015
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines.Microbes and infection, , Volume: 13, Issue:7, 2011
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study.Infection and immunity, , Volume: 76, Issue:5, 2008
Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F.Infection and immunity, , Volume: 74, Issue:11, 2006
Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of M. ulcerans in vitro and in vivo.Cellular microbiology, , Volume: 7, Issue:9, 2005
Mycobacterium ulcerans cytotoxicity in an adipose cell model.Infection and immunity, , Volume: 69, Issue:11, 2001
[Mycobacterium ulcerans infection].Annales de medecine interne, , Volume: 151, Issue:5, 2000
Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.Science (New York, N.Y.), , Feb-05, Volume: 283, Issue:5403, 1999
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls.Toxins, , 09-04, Volume: 11, Issue:9, 2019
Shaping mycolactone for therapeutic use against inflammatory disorders.Science translational medicine, , May-27, Volume: 7, Issue:289, 2015
Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.PLoS neglected tropical diseases, , Volume: 14, Issue:6, 2020
RNA Aptamer That Specifically Binds to Mycolactone and Serves as a Diagnostic Tool for Diagnosis of Buruli Ulcer.PLoS neglected tropical diseases, , Volume: 10, Issue:10, 2016
Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography.PLoS neglected tropical diseases, , Volume: 9, Issue:11, 2015
Synthesis of the mycolactone core by ring-closing metathesis.Chemical communications (Cambridge, England), , Nov-28, Issue:44, 2006
Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens.Cellular and molecular life sciences : CMLS, , Volume: 71, Issue:13, 2014
Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study.Infection and immunity, , Volume: 76, Issue:5, 2008
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis.PLoS pathogens, , May-04, Volume: 3, Issue:5, 2007
Evidence for an intramacrophage growth phase of Mycobacterium ulcerans.Infection and immunity, , Volume: 75, Issue:2, 2007
Buruli ulcer: emerging from obscurity.Lancet (London, England), , Jun-03, Volume: 367, Issue:9525, 2006
A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells.Infection and immunity, , Volume: 68, Issue:2, 2000
Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease.Journal of clinical microbiology, , Volume: 56, Issue:4, 2018
Evidence for an intramacrophage growth phase of Mycobacterium ulcerans.Infection and immunity, , Volume: 75, Issue:2, 2007
Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.Science (New York, N.Y.), , Feb-05, Volume: 283, Issue:5403, 1999
Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.PLoS pathogens, , Volume: 19, Issue:11, 2023
Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity.Toxins, , 08-02, Volume: 15, Issue:8, 2023
Behavioral interplay between mosquito and mycolactone produced by Mycobacterium ulcerans and bacterial gene expression induced by mosquito proximity.PloS one, , Volume: 18, Issue:8, 2023
From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone.Toxins, , 05-30, Volume: 15, Issue:6, 2023
Can membrane composition traffic toxins? Mycolactone and preferential membrane interactions.Biophysical journal, , 11-15, Volume: 121, Issue:22, 2022
Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells.PLoS neglected tropical diseases, , Volume: 16, Issue:8, 2022
Induced Synthesis of Mycolactone Restores the Pathogenesis of Frontiers in immunology, , Volume: 13, 2022
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.PLoS pathogens, , Volume: 18, Issue:1, 2022
Biochemical and Biological Assays of Mycolactone-Mediated Inhibition of Sec61.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Competitive ELISA for the Detection and Quantification of Mycobacterium ulcerans Mycolactone.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Conditions for Handling and Optimal Storage of Mycolactone.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Overview: Mycolactone , the Macrolide Toxin of Mycobacterium ulcerans.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Transcriptional adaptation of Virulence, , Volume: 12, Issue:1, 2021
Natural antioxidants attenuate mycolactone toxicity to RAW 264.7 macrophages.Experimental biology and medicine (Maywood, N.J.), , Volume: 246, Issue:17, 2021
Ketogenic Diet Impairment of Mycobacterium ulcerans Growth and Toxin Production and Enhancement of Host Response to Infection in an Experimental Mouse Model.The Journal of infectious diseases, , 12-01, Volume: 224, Issue:11, 2021
Immunity against Mycobacterium ulcerans: The subversive role of mycolactone.Immunological reviews, , Volume: 301, Issue:1, 2021
The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer.Frontiers in immunology, , Volume: 12, 2021
Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology.PLoS pathogens, , Volume: 16, Issue:12, 2020
The diversity of mycolactone-producing mycobacteria.Microbial pathogenesis, , Volume: 149, 2020
Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.PLoS neglected tropical diseases, , Volume: 14, Issue:6, 2020
Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Science advances, , Volume: 6, Issue:9, 2020
Pharmacologic management of Expert review of clinical pharmacology, , Volume: 13, Issue:4, 2020
Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis.Toxins, , 03-25, Volume: 11, Issue:3, 2019
Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease.Biology of the cell, , Volume: 110, Issue:11, 2018
Naturally occurring a loss of a giant plasmid from Mycobacterium ulcerans subsp. shinshuense makes it non-pathogenic.Scientific reports, , 05-29, Volume: 8, Issue:1, 2018
Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans.PLoS computational biology, , Volume: 14, Issue:2, 2018
Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease.Journal of clinical microbiology, , Volume: 56, Issue:4, 2018
The potent effect of mycolactone on lipid membranes.PLoS pathogens, , Volume: 14, Issue:1, 2018
Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria.Virulence, , 11-17, Volume: 8, Issue:8, 2017
Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.PLoS neglected tropical diseases, , Volume: 11, Issue:8, 2017
The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.ACS chemical biology, , 05-19, Volume: 12, Issue:5, 2017
Mycobacterium ulcerans mycolactone interferes with adhesion, migration and proliferation of primary human keratinocytes and HaCaT cell line.Archives of dermatological research, , Volume: 309, Issue:3, 2017
Molecular Characterization of Mycolactone Producing Mycobacteria from Aquatic Environments in Buruli Ulcer Non-Endemic Areas in Côte d'Ivoire.International journal of environmental research and public health, , 02-11, Volume: 14, Issue:2, 2017
Mycobacterium ulcerans toxin, mycolactone may enhance host-seeking and oviposition behaviour by Aedes aegypti (L.) (Diptera: Culicidae).Environmental microbiology, , Volume: 19, Issue:5, 2017
RNA Aptamer That Specifically Binds to Mycolactone and Serves as a Diagnostic Tool for Diagnosis of Buruli Ulcer.PLoS neglected tropical diseases, , Volume: 10, Issue:10, 2016
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer.Molecular pain, , Volume: 12, 2016
Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model.PLoS neglected tropical diseases, , Volume: 10, Issue:4, 2016
FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced by Mycobacterium ulcerans and Switch M. ulcerans into a Low Mycolactone Producer.Journal of immunology (Baltimore, Md. : 1950), , Mar-15, Volume: 196, Issue:6, 2016
Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone.Journal of cell science, , Apr-01, Volume: 129, Issue:7, 2016
Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease.Cellular microbiology, , Volume: 18, Issue:1, 2016
Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease.Scientific reports, , Dec-04, Volume: 5, 2015
Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography.PLoS neglected tropical diseases, , Volume: 9, Issue:11, 2015
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.PLoS pathogens, , Volume: 11, Issue:7, 2015
Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease.PLoS neglected tropical diseases, , Volume: 9, Issue:6, 2015
Source tracking Mycobacterium ulcerans infections in the Ashanti region, Ghana.PLoS neglected tropical diseases, , Volume: 9, Issue:1, 2015
Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressings.Journal of wound care, , Volume: 23, Issue:8, 2014
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.Cell, , Jun-19, Volume: 157, Issue:7, 2014
The angiotensin II type 2 receptor for pain control.Cell, , Jun-19, Volume: 157, Issue:7, 2014
Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease.BMC infectious diseases, , Apr-15, Volume: 14, 2014
The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.PLoS pathogens, , Volume: 10, Issue:4, 2014
Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.Biochemical Society transactions, , Volume: 42, Issue:1, 2014
Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.PLoS neglected tropical diseases, , Volume: 8, Issue:1, 2014
Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease.PLoS neglected tropical diseases, , Volume: 7, Issue:3, 2013
Buruli ulcer and mycolactone-producing mycobacteria.Japanese journal of infectious diseases, , Volume: 66, Issue:2, 2013
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.The Journal of clinical investigation, , Volume: 123, Issue:4, 2013
On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer.BMC genomics, , Jun-19, Volume: 13, 2012
Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium ulcerans vaccination.PloS one, , Volume: 7, Issue:3, 2012
The genome, evolution and diversity of Mycobacterium ulcerans.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, , Volume: 12, Issue:3, 2012
A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-16, Volume: 17, Issue:51, 2011
Buruli ulcer.Human vaccines, , Volume: 7, Issue:11, 2011
Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.PLoS neglected tropical diseases, , Volume: 5, Issue:7, 2011
[Role of mycolactone in the nerve damage of Buruli ulcer (Mycobacterium ulcerans infection)].Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, , Volume: 80, Issue:1, 2011
Chemistry of mycolactones, the causative toxins of Buruli ulcer.Proceedings of the National Academy of Sciences of the United States of America, , Apr-26, Volume: 108, Issue:17, 2011
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Mycobacterium ulcerans triggers T-cell immunity followed by local and regional but not systemic immunosuppression.Infection and immunity, , Volume: 79, Issue:1, 2011
Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines.Microbes and infection, , Volume: 13, Issue:7, 2011
Highly sensitive, operationally simple, cost/time effective detection of the mycolactones from the human pathogen Mycobacterium ulcerans.Chemical communications (Cambridge, England), , Mar-07, Volume: 46, Issue:9, 2010
Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue.PLoS neglected tropical diseases, , Jan-05, Volume: 4, Issue:1, 2010
Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.Journal of immunology (Baltimore, Md. : 1950), , Feb-01, Volume: 184, Issue:3, 2010
Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.PLoS neglected tropical diseases, , Nov-24, Volume: 3, Issue:11, 2009
Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease.The Journal of infectious diseases, , Dec-01, Volume: 200, Issue:11, 2009
Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer.The Lancet. Infectious diseases, , Volume: 9, Issue:11, 2009
Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to Mycobacterium ulcerans.Applied and environmental microbiology, , Volume: 75, Issue:17, 2009
Mycolactone inhibits monocyte cytokine production by a posttranscriptional mechanism.Journal of immunology (Baltimore, Md. : 1950), , Feb-15, Volume: 182, Issue:4, 2009
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study.Infection and immunity, , Volume: 76, Issue:5, 2008
Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.PLoS neglected tropical diseases, , Volume: 2, Issue:10, 2008
Membrane Active Immunomodulator As a Novel Therapy for an Infectious Bacterial Disease, Buruli Ulcer.In vivo (Athens, Greece), , Volume: 36, Issue:6
[Paradoxical reactions and responses during antibiotic treatment for Mycobacterium ulcerans infection (Buruli ulcer). Four cases from French Guiana].Annales de dermatologie et de venereologie, , Volume: 141, Issue:6-7
Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.PLoS pathogens, , Volume: 19, Issue:11, 2023
Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity.Toxins, , 08-02, Volume: 15, Issue:8, 2023
Behavioral interplay between mosquito and mycolactone produced by Mycobacterium ulcerans and bacterial gene expression induced by mosquito proximity.PloS one, , Volume: 18, Issue:8, 2023
From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone.Toxins, , 05-30, Volume: 15, Issue:6, 2023
Overview: Mycolactone , the Macrolide Toxin of Mycobacterium ulcerans.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Can membrane composition traffic toxins? Mycolactone and preferential membrane interactions.Biophysical journal, , 11-15, Volume: 121, Issue:22, 2022
Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells.PLoS neglected tropical diseases, , Volume: 16, Issue:8, 2022
Induced Synthesis of Mycolactone Restores the Pathogenesis of Frontiers in immunology, , Volume: 13, 2022
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.PLoS pathogens, , Volume: 18, Issue:1, 2022
Biochemical and Biological Assays of Mycolactone-Mediated Inhibition of Sec61.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Competitive ELISA for the Detection and Quantification of Mycobacterium ulcerans Mycolactone.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Conditions for Handling and Optimal Storage of Mycolactone.Methods in molecular biology (Clifton, N.J.), , Volume: 2387, 2022
Transcriptional adaptation of Virulence, , Volume: 12, Issue:1, 2021
Natural antioxidants attenuate mycolactone toxicity to RAW 264.7 macrophages.Experimental biology and medicine (Maywood, N.J.), , Volume: 246, Issue:17, 2021
Ketogenic Diet Impairment of Mycobacterium ulcerans Growth and Toxin Production and Enhancement of Host Response to Infection in an Experimental Mouse Model.The Journal of infectious diseases, , 12-01, Volume: 224, Issue:11, 2021
Immunity against Mycobacterium ulcerans: The subversive role of mycolactone.Immunological reviews, , Volume: 301, Issue:1, 2021
The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer.Frontiers in immunology, , Volume: 12, 2021
Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology.PLoS pathogens, , Volume: 16, Issue:12, 2020
The diversity of mycolactone-producing mycobacteria.Microbial pathogenesis, , Volume: 149, 2020
Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.PLoS neglected tropical diseases, , Volume: 14, Issue:6, 2020
Pharmacologic management of Expert review of clinical pharmacology, , Volume: 13, Issue:4, 2020
Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Science advances, , Volume: 6, Issue:9, 2020
Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis.Toxins, , 03-25, Volume: 11, Issue:3, 2019
Naturally occurring a loss of a giant plasmid from Mycobacterium ulcerans subsp. shinshuense makes it non-pathogenic.Scientific reports, , 05-29, Volume: 8, Issue:1, 2018
Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans.PLoS computational biology, , Volume: 14, Issue:2, 2018
The potent effect of mycolactone on lipid membranes.PLoS pathogens, , Volume: 14, Issue:1, 2018
Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease.Biology of the cell, , Volume: 110, Issue:11, 2018
Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease.Journal of clinical microbiology, , Volume: 56, Issue:4, 2018
The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.ACS chemical biology, , 05-19, Volume: 12, Issue:5, 2017
Mycobacterium ulcerans mycolactone interferes with adhesion, migration and proliferation of primary human keratinocytes and HaCaT cell line.Archives of dermatological research, , Volume: 309, Issue:3, 2017
Mycobacterium ulcerans toxin, mycolactone may enhance host-seeking and oviposition behaviour by Aedes aegypti (L.) (Diptera: Culicidae).Environmental microbiology, , Volume: 19, Issue:5, 2017
Molecular Characterization of Mycolactone Producing Mycobacteria from Aquatic Environments in Buruli Ulcer Non-Endemic Areas in Côte d'Ivoire.International journal of environmental research and public health, , 02-11, Volume: 14, Issue:2, 2017
Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria.Virulence, , 11-17, Volume: 8, Issue:8, 2017
Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.PLoS neglected tropical diseases, , Volume: 11, Issue:8, 2017
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer.Molecular pain, , Volume: 12, 2016
Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease.Cellular microbiology, , Volume: 18, Issue:1, 2016
Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model.PLoS neglected tropical diseases, , Volume: 10, Issue:4, 2016
Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone.Journal of cell science, , Apr-01, Volume: 129, Issue:7, 2016
FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced by Mycobacterium ulcerans and Switch M. ulcerans into a Low Mycolactone Producer.Journal of immunology (Baltimore, Md. : 1950), , Mar-15, Volume: 196, Issue:6, 2016
RNA Aptamer That Specifically Binds to Mycolactone and Serves as a Diagnostic Tool for Diagnosis of Buruli Ulcer.PLoS neglected tropical diseases, , Volume: 10, Issue:10, 2016
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.PLoS pathogens, , Volume: 11, Issue:7, 2015
Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease.PLoS neglected tropical diseases, , Volume: 9, Issue:6, 2015
Source tracking Mycobacterium ulcerans infections in the Ashanti region, Ghana.PLoS neglected tropical diseases, , Volume: 9, Issue:1, 2015
Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography.PLoS neglected tropical diseases, , Volume: 9, Issue:11, 2015
Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease.Scientific reports, , Dec-04, Volume: 5, 2015
Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.PLoS neglected tropical diseases, , Volume: 8, Issue:1, 2014
Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.Biochemical Society transactions, , Volume: 42, Issue:1, 2014
Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease.BMC infectious diseases, , Apr-15, Volume: 14, 2014
The angiotensin II type 2 receptor for pain control.Cell, , Jun-19, Volume: 157, Issue:7, 2014
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.Cell, , Jun-19, Volume: 157, Issue:7, 2014
Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressings.Journal of wound care, , Volume: 23, Issue:8, 2014
The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.PLoS pathogens, , Volume: 10, Issue:4, 2014
Buruli ulcer and mycolactone-producing mycobacteria.Japanese journal of infectious diseases, , Volume: 66, Issue:2, 2013
Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease.PLoS neglected tropical diseases, , Volume: 7, Issue:3, 2013
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.The Journal of clinical investigation, , Volume: 123, Issue:4, 2013
The genome, evolution and diversity of Mycobacterium ulcerans.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, , Volume: 12, Issue:3, 2012
Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium ulcerans vaccination.PloS one, , Volume: 7, Issue:3, 2012
On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer.BMC genomics, , Jun-19, Volume: 13, 2012
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Mycobacterium ulcerans triggers T-cell immunity followed by local and regional but not systemic immunosuppression.Infection and immunity, , Volume: 79, Issue:1, 2011
Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines.Microbes and infection, , Volume: 13, Issue:7, 2011
Chemistry of mycolactones, the causative toxins of Buruli ulcer.Proceedings of the National Academy of Sciences of the United States of America, , Apr-26, Volume: 108, Issue:17, 2011
[Role of mycolactone in the nerve damage of Buruli ulcer (Mycobacterium ulcerans infection)].Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, , Volume: 80, Issue:1, 2011
Buruli ulcer.Human vaccines, , Volume: 7, Issue:11, 2011
Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.PLoS neglected tropical diseases, , Volume: 5, Issue:7, 2011
A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-16, Volume: 17, Issue:51, 2011
Highly sensitive, operationally simple, cost/time effective detection of the mycolactones from the human pathogen Mycobacterium ulcerans.Chemical communications (Cambridge, England), , Mar-07, Volume: 46, Issue:9, 2010
Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue.PLoS neglected tropical diseases, , Jan-05, Volume: 4, Issue:1, 2010
Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.Journal of immunology (Baltimore, Md. : 1950), , Feb-01, Volume: 184, Issue:3, 2010
Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.PLoS neglected tropical diseases, , Nov-24, Volume: 3, Issue:11, 2009
Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease.The Journal of infectious diseases, , Dec-01, Volume: 200, Issue:11, 2009
Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer.The Lancet. Infectious diseases, , Volume: 9, Issue:11, 2009
Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to Mycobacterium ulcerans.Applied and environmental microbiology, , Volume: 75, Issue:17, 2009
Mycolactone inhibits monocyte cytokine production by a posttranscriptional mechanism.Journal of immunology (Baltimore, Md. : 1950), , Feb-15, Volume: 182, Issue:4, 2009
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study.Infection and immunity, , Volume: 76, Issue:5, 2008
Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.PLoS neglected tropical diseases, , Volume: 2, Issue:10, 2008
[Paradoxical reactions and responses during antibiotic treatment for Mycobacterium ulcerans infection (Buruli ulcer). Four cases from French Guiana].Annales de dermatologie et de venereologie, , Volume: 141, Issue:6-7
Membrane Active Immunomodulator As a Novel Therapy for an Infectious Bacterial Disease, Buruli Ulcer.In vivo (Athens, Greece), , Volume: 36, Issue:6
Ketogenic Diet Impairment of Mycobacterium ulcerans Growth and Toxin Production and Enhancement of Host Response to Infection in an Experimental Mouse Model.The Journal of infectious diseases, , 12-01, Volume: 224, Issue:11, 2021
Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.PLoS neglected tropical diseases, , Volume: 14, Issue:6, 2020
Mycolactone displays anti-inflammatory effects on the nervous system.PLoS neglected tropical diseases, , Volume: 11, Issue:11, 2017
FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced by Mycobacterium ulcerans and Switch M. ulcerans into a Low Mycolactone Producer.Journal of immunology (Baltimore, Md. : 1950), , Mar-15, Volume: 196, Issue:6, 2016
Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model.PLoS neglected tropical diseases, , Volume: 10, Issue:4, 2016
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.Cell, , Jun-19, Volume: 157, Issue:7, 2014
Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease.PLoS neglected tropical diseases, , Volume: 7, Issue:3, 2013
Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission.Microbes and infection, , Volume: 14, Issue:9, 2012
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.PLoS neglected tropical diseases, , Volume: 2, Issue:10, 2008
Evidence for an intramacrophage growth phase of Mycobacterium ulcerans.Infection and immunity, , Volume: 75, Issue:2, 2007
Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection.Infection and immunity, , Volume: 75, Issue:8, 2007
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission.Microbes and infection, , Volume: 14, Issue:9, 2012
Chemistry of mycolactones, the causative toxins of Buruli ulcer.Proceedings of the National Academy of Sciences of the United States of America, , Apr-26, Volume: 108, Issue:17, 2011
First report of a mycolactone-producing Mycobacterium infection in fish agriculture in Belgium.FEMS microbiology letters, , Volume: 286, Issue:1, 2008
The evolving story of Mycobacterium tuberculosis clade members detected in fish.Journal of fish diseases, , Volume: 29, Issue:9, 2006
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer.Molecular pain, , Volume: 12, 2016
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.Cell, , Jun-19, Volume: 157, Issue:7, 2014
Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study.Infection and immunity, , Volume: 76, Issue:5, 2008
Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.PLoS pathogens, , Volume: 19, Issue:11, 2023
Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology.PLoS pathogens, , Volume: 16, Issue:12, 2020
Shaping mycolactone for therapeutic use against inflammatory disorders.Science translational medicine, , May-27, Volume: 7, Issue:289, 2015
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer.The Lancet. Infectious diseases, , Volume: 9, Issue:11, 2009
Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.American journal of physiology. Regulatory, integrative and comparative physiology, , Volume: 300, Issue:3, 2011
Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.Microbes and infection, , Volume: 11, Issue:2, 2009
Transcriptional adaptation of Virulence, , Volume: 12, Issue:1, 2021
Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease.Journal of clinical microbiology, , Volume: 56, Issue:4, 2018
Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission.Microbes and infection, , Volume: 14, Issue:9, 2012
A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-16, Volume: 17, Issue:51, 2011
Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F.Infection and immunity, , Volume: 74, Issue:11, 2006
Responses to chemical cross-talk between the Mycobacterium ulcerans toxin, mycolactone, and Staphylococcus aureus.Scientific reports, , 06-03, Volume: 11, Issue:1, 2021
Mycobacterium ulcerans mycolactones-fungi crosstalking.Scientific reports, , 02-28, Volume: 9, Issue:1, 2019
Mycolactone-producing Mycobacterium marinum infection in captive Hong Kong warty newts and pathological evidence of impaired host immune function.Diseases of aquatic organisms, , Mar-21, Volume: 123, Issue:3, 2017
Molecular Characterization of Mycolactone Producing Mycobacteria from Aquatic Environments in Buruli Ulcer Non-Endemic Areas in Côte d'Ivoire.International journal of environmental research and public health, , 02-11, Volume: 14, Issue:2, 2017
IFN-gamma-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone.Journal of immunology (Baltimore, Md. : 1950), , Jan-15, Volume: 184, Issue:2, 2010
Mycobacterium ulcerans and other mycolactone-producing mycobacteria should be considered a single species.PLoS neglected tropical diseases, , Jul-27, Volume: 4, Issue:7, 2010
First report of a mycolactone-producing Mycobacterium infection in fish agriculture in Belgium.FEMS microbiology letters, , Volume: 286, Issue:1, 2008
Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection.Infection and immunity, , Volume: 75, Issue:8, 2007
Impact of Mycobacterium ulcerans biofilm on transmissibility to ecological niches and Buruli ulcer pathogenesis.PLoS pathogens, , May-04, Volume: 3, Issue:5, 2007
Bacterial therapeutics.Nature reviews. Microbiology, , Volume: 5, Issue:3, 2007
Evidence for an intramacrophage growth phase of Mycobacterium ulcerans.Infection and immunity, , Volume: 75, Issue:2, 2007
The evolving story of Mycobacterium tuberculosis clade members detected in fish.Journal of fish diseases, , Volume: 29, Issue:9, 2006
Buruli ulcer: emerging from obscurity.Lancet (London, England), , Jun-03, Volume: 367, Issue:9525, 2006
Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of M. ulcerans in vitro and in vivo.Cellular microbiology, , Volume: 7, Issue:9, 2005
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.Cellular microbiology, , Volume: 7, Issue:8, 2005
Colonization of the salivary glands of Naucoris cimicoides by Mycobacterium ulcerans requires host plasmatocytes and a macrolide toxin, mycolactone.Cellular microbiology, , Volume: 7, Issue:7, 2005
Uptake and cellular actions of mycolactone, a virulence determinant for Mycobacterium ulcerans.Microbial pathogenesis, , Volume: 34, Issue:2, 2003
Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence.Infection and immunity, , Volume: 71, Issue:2, 2003
Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.Chemical communications (Cambridge, England), , Nov-21, Issue:22, 2003
Mycolactones and Mycobacterium ulcerans disease.Lancet (London, England), , Sep-27, Volume: 362, Issue:9389, 2003
[Mycobacterium ulcerans infection].Annales de medecine interne, , Volume: 151, Issue:5, 2000
Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.Science (New York, N.Y.), , Feb-05, Volume: 283, Issue:5403, 1999
Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls.Toxins, , 09-04, Volume: 11, Issue:9, 2019
Shaping mycolactone for therapeutic use against inflammatory disorders.Science translational medicine, , May-27, Volume: 7, Issue:289, 2015
Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease.Journal of clinical microbiology, , Volume: 56, Issue:4, 2018
Evidence for an intramacrophage growth phase of Mycobacterium ulcerans.Infection and immunity, , Volume: 75, Issue:2, 2007
Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.Science (New York, N.Y.), , Feb-05, Volume: 283, Issue:5403, 1999
Safety/Toxicity (3)
| Article | Year |
|---|
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.
Cell death & disease, , 03-14, Volume: 9, Issue:3 | 2018 |
Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
PLoS neglected tropical diseases, , Volume: 11, Issue:8 | 2017 |
Antioxidants protect keratinocytes against M. ulcerans mycolactone cytotoxicity.
PloS one, , Nov-04, Volume: 5, Issue:11 | 2010 |