Proteins > Proteasome subunit beta type-5
Page last updated: 2024-08-07 13:10:33

Proteasome subunit beta type-5

A proteasome subunit beta type-5 that is encoded in the genome of human. [PRO:DNx]

Synonyms

EC 3.4.25.1;
Macropain epsilon chain;
Multicatalytic endopeptidase complex epsilon chain;
Proteasome chain 6;
Proteasome epsilon chain;
Proteasome subunit MB1;
Proteasome subunit X

Research

Bioassay Publications (71)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (8.45)29.6817
2010's52 (73.24)24.3611
2020's13 (18.31)2.80

Compounds (54)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gallic acidHomo sapiens (human)IC507,100.000011
emodinHomo sapiens (human)IC501.220011
vorinostatHomo sapiens (human)IC5025.000033
2-methylquinolineHomo sapiens (human)IC5025.000011
3-methylquinolineHomo sapiens (human)IC5025.000011
epigallocatechin gallateHomo sapiens (human)IC506.362033
gallocatecholHomo sapiens (human)IC501,200.000011
epicatechin gallateHomo sapiens (human)IC500.194011
liquiritigeninHomo sapiens (human)IC50100.000011
(-)-gallocatechin gallateHomo sapiens (human)IC500.187011
vincaleukoblastineHomo sapiens (human)IC5022.290022
medicarpinHomo sapiens (human)IC50100.000011
bortezomibHomo sapiens (human)IC5015,084.28363234
bortezomibHomo sapiens (human)Ki0.006733
5-amino-8-hydroxyquinolineHomo sapiens (human)IC500.600088
naringeninHomo sapiens (human)IC5045.200022
eriodictyolHomo sapiens (human)IC5015.400022
sdz 283-910Homo sapiens (human)IC500.900011
benzyloxycarbonylleucyl-leucyl-leucine aldehydeHomo sapiens (human)IC500.60881010
benzyloxycarbonylleucyl-leucyl-leucine aldehydeHomo sapiens (human)Ki0.016155
mg 262Homo sapiens (human)Ki0.002311
isoliquiritigeninHomo sapiens (human)IC504.880011
(2S)-7-hydroxyflavanoneHomo sapiens (human)IC505.210011
curcuminHomo sapiens (human)IC5010.000022
orlistatHomo sapiens (human)IC50100.000011
quercetinHomo sapiens (human)IC502.750022
formononetinHomo sapiens (human)IC50100.000011
apigeninHomo sapiens (human)IC501.400022
luteolinHomo sapiens (human)IC501.400022
kaempferolHomo sapiens (human)IC5010.750022
genisteinHomo sapiens (human)IC5037.130022
chrysinHomo sapiens (human)IC505.500022
myricetinHomo sapiens (human)IC5011.000022
daidzeinHomo sapiens (human)IC50100.000011
benzyloxycarbonyl-phe-ala-fluormethylketoneHomo sapiens (human)IC50100.000011
(-)-catechin-3-O-gallateHomo sapiens (human)IC500.124011
lactacystinHomo sapiens (human)IC502.723266
2-(quinolin-2-ylmethylene)hydrazinecarbothioamideHomo sapiens (human)IC5010.000022
clasto-lactacystin beta-lactoneHomo sapiens (human)IC500.049011
benzyloxycarbonyl-isoleucyl-glutamyl(o-tert-butyl)-alanyl-leucinalHomo sapiens (human)Ki0.001011
epoxomicinHomo sapiens (human)IC500.025633
marizomibHomo sapiens (human)IC500.007644
ridaifen-bHomo sapiens (human)IC506.560011
carfilzomibHomo sapiens (human)IC500.02371717
tyropeptin aHomo sapiens (human)IC5024.380033
pr-957Homo sapiens (human)IC500.480266
delanzomibHomo sapiens (human)IC500.003222
belactosin aHomo sapiens (human)IC501.426733
oprozomibHomo sapiens (human)IC500.032755
ixazomibHomo sapiens (human)IC500.006555
mln 9708Homo sapiens (human)IC500.008411
acy-1215Homo sapiens (human)IC5025.000033
pi-1840Homo sapiens (human)IC500.092011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
am 404Homo sapiens (human)EC5028.000011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
chlorpromazineHomo sapiens (human)EC20045.125044
bortezomibHomo sapiens (human)Ki500.010022
pr-957Homo sapiens (human)Ki500.335022

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
threonine-type endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
peptidase activitymolecular functionCatalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
centrosomecellular componentA structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
proteasome complexcellular componentA large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. [GOC:rb, Wikipedia:Proteasome]
proteasome core complexcellular componentA multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. [GOC:rb, PMID:10806206]
proteasome core complex, beta-subunit complexcellular componentThe proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]

Involved In

This protein is involved in 2 target(s):

TargetCategoryDefinition
response to oxidative stressbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
proteasome-mediated ubiquitin-dependent protein catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:go_curators]