A voltage-dependent calcium channel subunit alpha-2/delta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54289]
Piperazinyl Bicyclic Derivatives as Selective Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels.ACS medicinal chemistry letters, , Nov-11, Volume: 12, Issue:11, 2021
Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Alkylsulfanyl analogs as potent αBioorganic & medicinal chemistry letters, , 06-15, Volume: 28, Issue:11, 2018
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| sarcoplasmic reticulum | cellular component | A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| neuronal dense core vesicle | cellular component | A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176] |
| Target | Category | Definition |
|---|
| calcium ion transport | biological process | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| regulation of calcium ion transport | biological process | Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| regulation of ventricular cardiac muscle cell membrane repolarization | biological process | Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] |
| calcium ion transport into cytosol | biological process | The directed movement of calcium ions (Ca2+) into the cytosol. [GOC:dph, GOC:tb] |
| calcium ion transmembrane transport via high voltage-gated calcium channel | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel. [GOC:dph] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane depolarization during bundle of His cell action potential | biological process | The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of heart rate by cardiac conduction | biological process | A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| calcium ion import across plasma membrane | biological process | The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |
| regulation of membrane repolarization during action potential | biological process | Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential. [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8] |
| positive regulation of high voltage-gated calcium channel activity | biological process | Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] |
| regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | biological process | Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048] |
| cellular response to amyloid-beta | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824] |