Page last updated: 2024-10-15

fr 167653

Description

FR 167653: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135484078
SCHEMBL ID7492343
MeSH IDM0272559

Synonyms (19)

Synonym
fr 167653
fr167653
158876-66-5
FT-0643543
SCHEMBL7492343
fr-167653
DTXSID60430965
sulfuric acid--1-[7-(4-fluorophenyl)-8-(pyridin-4-yl)-3,4-dihydropyrazolo[5,1-c][1,2,4]triazin-2(6h)-yl]-2-phenylethane-1,2-dione (1/1)
AKOS027381815
7-(4-fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate
1-(7-(4-fluorophenyl)-8-(pyridin-4-yl)-3,4-dihydropyrazolo[5,1-c][1,2,4]triazin-2(1h)-yl)-2-phenylethane-1,2-dione sulfate
7-(4-fluorophenyl)-1 pound not2 pound not3 pound not4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5 pound not1-c][1 pound not2 pound not4]triazine sulfate
BCP25927
CS-0014258
HY-18754A
fr 167653 sulfate
1-(7-(4-fluorophenyl)-8-(pyridin-4-yl)-3,4-dihydropyrazolo[5,1-c][1,2,4]triazin-2(1h)-yl)-2-phenylethane-1,2-dionesulfate
1-[7-(4-fluorophenyl)-8-pyridin-4-yl-3,4-dihydro-1h-pyrazolo[5,1-c][1,2,4]triazin-2-yl]-2-phenylethane-1,2-dione;sulfuric acid
1-[7-(4-fluorophenyl)-8-pyridin-4-yl-4,6-dihydro-3h-pyrazolo[5,1-c][1,2,4]triazin-2-yl]-2-phenylethane-1,2-dione;sulfuric acid

Toxicity

ExcerptReference
" In porcine NHBD-LTx, we previously reported a 50% risk of PNF and toxic bile formation in grafts exposed to > or =30' warm ischemia (WI)."( Multifactorial biological modulation of warm ischemia reperfusion injury in liver transplantation from non-heart-beating donors eliminates primary nonfunction and reduces bile salt toxicity.
Balligand, E; Buurman, W; Deckx, H; Derveaux, K; Heedfeld, V; Hoekstra, H; Libbrecht, L; Liu, Q; Monbaliu, D; Parkkinen, J; Pirenne, J; Porte, RJ; Vaahtera, L; van Pelt, J; Vekemans, K; Wylin, T; Zeegers, M, 2009
)

Dosage Studied

ExcerptReference
" Rats treated with FR167653, a selective inhibitor of p38 MAPK, at a dosage of 10 mg x kg(-1) x d(-1), had a 29."( Role of p38 mitogen-activated protein kinase in neointimal hyperplasia after vascular injury.
Furukawa, Y; Iwasaki, A; Matsumori, A; Miyamoto, T; Nakano, A; Ohashi, N; Okada, M; Ono, K; Sasayama, S, 2000
)
" The effect of FR monotherapy was evaluated by treating allograft recipients at a dosage of 32 or 64 mg/kg/day intraperitoneally."( Significant prolongation of animal survival by combined therapy of FR167653 and cyclosporine A in rat renal allografts.
Azuma, H; Furuichi, K; Gotoh, R; Katsuoka, Y; Sakai, N; Takahara, S; Wada, T; Yazawa, K; Yokoyama, H, 2003
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (119)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's18 (15.13)18.2507
2000's91 (76.47)29.6817
2010's9 (7.56)24.3611
2020's1 (0.84)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (3.05%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other127 (96.95%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]