Proteins > Bile acid receptor
Page last updated: 2024-08-07 18:48:03

Bile acid receptor

A bile acid receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RI1]

Synonyms

Farnesoid X-activated receptor;
Farnesol receptor HRR-1;
Nuclear receptor subfamily 1 group H member 4;
Retinoid X receptor-interacting protein 14;
RXR-interacting protein 14

Research

Bioassay Publications (81)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's25 (30.86)29.6817
2010's44 (54.32)24.3611
2020's12 (14.81)2.80

Compounds (44)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
clotrimazoleHomo sapiens (human)IC503.240011
felodipineHomo sapiens (human)IC504.960011
flutrimazoleHomo sapiens (human)IC5013.800011
loratadineHomo sapiens (human)IC503.070011
nimodipineHomo sapiens (human)IC508.960011
raloxifeneHomo sapiens (human)IC5011.560011
sulconazoleHomo sapiens (human)IC506.880011
thyroxineHomo sapiens (human)IC507.860011
lithocholic acidHomo sapiens (human)IC500.018311
fulvestrantHomo sapiens (human)IC500.790011
6-hydroxydopaHomo sapiens (human)IC507.920011
ly 255283Homo sapiens (human)IC5035.200011
nbi 27914Homo sapiens (human)IC502.770011
5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diolHomo sapiens (human)IC501.310011
t0901317Homo sapiens (human)IC505.300011
6-bromoindirubin-3'-oximeHomo sapiens (human)IC503.400011
gw 7647Homo sapiens (human)IC504.910011
jhw 015Homo sapiens (human)IC503.220011
andrographolideHomo sapiens (human)IC509.700022
pregna-4,17-diene-3,16-dioneHomo sapiens (human)IC5027.477899
pregna-4,17-diene-3,16-dioneHomo sapiens (human)Ki5.000011
pregna-4,17-diene-3,16-dione, (17z)-isomerHomo sapiens (human)IC5051.094377
pregna-4,17-diene-3,16-dione, (17z)-isomerHomo sapiens (human)Ki5.000011
gw 4064Homo sapiens (human)IC500.065044
12-epi-scalarinHomo sapiens (human)IC5060.400011
glycoursodeoxycholic acidHomo sapiens (human)IC5098.400011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
benzbromaroneHomo sapiens (human)EC5024.500011
ono 1078Homo sapiens (human)EC5015.000011
lithocholic acidHomo sapiens (human)EC5042.233333
chenodeoxycholic acidHomo sapiens (human)EC5013.38063232
glycochenodeoxycholic acidHomo sapiens (human)EC503.000011
ursodeoxycholic acidHomo sapiens (human)EC5075.000022
cholic acidHomo sapiens (human)EC5081.666733
deoxycholic acidHomo sapiens (human)EC5047.500022
taurochenodeoxycholic acidHomo sapiens (human)EC503.000011
obeticholic acidHomo sapiens (human)EC506.20312525
t0901317Homo sapiens (human)EC501.900033
fexaramineHomo sapiens (human)EC500.154266
fexaramineHomo sapiens (human)Kd1,220.000011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)EC5014.551477
pregna-4,17-diene-3,16-dione, (17z)-isomerHomo sapiens (human)EC5012.000011
gw 4064Homo sapiens (human)EC500.43905656
way-362450Homo sapiens (human)EC500.045677
alisol b monoacetateHomo sapiens (human)EC503.570011
alisol c 23-acetateHomo sapiens (human)EC502.100011
alisol aHomo sapiens (human)EC5010.160011
alisol bHomo sapiens (human)EC508.800011
archazolid aHomo sapiens (human)EC500.200011
int-777Homo sapiens (human)EC50100.000033
alisol fHomo sapiens (human)EC5015.100011
alisol a 24-acetateHomo sapiens (human)EC5034.190011
4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acidHomo sapiens (human)EC500.373344

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gw 4064Homo sapiens (human)Activity0.064011

Enables

This protein enables 15 target(s):

TargetCategoryDefinition
RNA polymerase II transcription regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. [GOC:txnOH]
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
transcription coregulator bindingmolecular functionBinding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. [GOC:krc]
DNA-binding transcription activator activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
DNA-binding transcription factor activitymolecular functionA transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
nuclear receptor bindingmolecular functionBinding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974]
bile acid bindingmolecular functionBinding to a bile acid, a steroid carboxylic acids occurring in bile. [GOC:rph]
bile acid receptor activitymolecular functionCombining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile. [GOC:bf, PMID:10334992, PMID:12718893]
sequence-specific DNA bindingmolecular functionBinding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]
nuclear retinoid X receptor bindingmolecular functionBinding to a nuclear retinoid X receptor. [GOC:ai]
chenodeoxycholic acid bindingmolecular functionBinding to chenodeoxycholic acid. [GOC:bf, GOC:TermGenie, PMID:10334992]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 4 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
euchromatincellular componentA dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. [PMID:32017156]
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]
RNA polymerase II transcription regulator complexcellular componentA transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]

Involved In

This protein is involved in 46 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
nitrogen catabolite activation of transcription from RNA polymerase II promoterbiological processA transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. [GOC:mah, GOC:txnOH, PMID:19104072]
intracellular glucose homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of glucose within a cell. [GOC:dph, GOC:go_curators, GOC:tb]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
transcription by RNA polymerase IIbiological processThe synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
inflammatory responsebiological processThe immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
cell-cell junction assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form a junction between cells. [GOC:ai]
Notch signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:go_curators, GOC:signaling]
bile acid metabolic processbiological processThe chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:go_curators]
negative regulation of tumor necrosis factor-mediated signaling pathwaybiological processAny process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb]
regulation of low-density lipoprotein particle clearancebiological processAny process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]
intracellular receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to a receptor located within a cell. [GOC:bf, GOC:mah]
negative regulation of type II interferon productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
negative regulation of interleukin-1 productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. [GOC:mah]
negative regulation of interleukin-2 productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. [GOC:mah]
negative regulation of interleukin-6 productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
negative regulation of tumor necrosis factor productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120]
positive regulation of interleukin-17 productionbiological processAny process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511]
toll-like receptor 9 signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 9. [GOC:add, PMID:16551253, PMID:17328678]
regulation of urea metabolic processbiological processAny process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea. [GOC:mah]
intracellular triglyceride homeostasisbiological processA homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell. [GOC:BHF]
positive regulation of insulin secretion involved in cellular response to glucose stimulusbiological processAny process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]
bile acid signaling pathwaybiological processThe series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:signaling, PMID:12016314]
intracellular bile acid receptor signaling pathwaybiological processThe series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:10334992]
cholesterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
defense response to bacteriumbiological processReactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of canonical NF-kappaB signal transductionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of insulin receptor signaling pathwaybiological processAny process that increases the frequency, rate or extent of insulin receptor signaling. [GOC:bf]
fatty acid homeostasisbiological processAny process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. [GOC:BHF, GOC:rl]
regulation of insulin secretion involved in cellular response to glucose stimulusbiological processAny process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:BHF, GOC:dph]
regulation of bile acid biosynthetic processbiological processAny process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
cellular response to fatty acidbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:mah]
cellular response to organonitrogen compoundbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. [GOC:mah]
negative regulation of monocyte chemotactic protein-1 productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1. [GOC:mah]
regulation of cholesterol metabolic processbiological processAny process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]
cellular response to bile acidbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
positive regulation of adipose tissue developmentbiological processAny process that activates or increases the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
positive regulation of phosphatidic acid biosynthetic processbiological processAny process that activates or increases the frequency, rate or extent of phosphatidic acid biosynthetic process. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959]
positive regulation of glutamate metabolic processbiological processAny process that activates or increases the frequency, rate or extent of glutamate metabolic process. [GOC:sl]
positive regulation of ammonia assimilation cyclebiological processAny process that activates or increases the frequency, rate or extent of ammonia assimilation cycle. [GOC:BHF]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
negative regulation of inflammatory responsebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]