Dual specificity tyrosine-phosphorylation-regulated kinase 1B

A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y463]

Synonyms

EC 2.7.12.1;
Minibrain-related kinase;
Mirk protein kinase

Research

Bioassay Publications (21)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (14.29)	29.6817
2010's	16 (76.19)	24.3611
2020's	2 (9.52)	2.80

Compounds (124)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
staurosporine	Homo sapiens (human)	IC50	0.0017	3	3
cyc 202	Homo sapiens (human)	IC50	1.2000	1	1
ml106	Homo sapiens (human)	IC50	0.6970	1	1
6-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamine	Homo sapiens (human)	IC50	0.4520	1	1
harmine	Homo sapiens (human)	IC50	0.1183	5	5
harmine	Homo sapiens (human)	Ki	0.1660	1	1
as 605240	Homo sapiens (human)	IC50	0.0800	1	1
leucettamine b	Homo sapiens (human)	IC50	2.8500	2	2
cx 4945	Homo sapiens (human)	IC50	0.0064	3	3
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(thiophen-2-ylmethyl)-4-quinazolinamine	Homo sapiens (human)	IC50	0.0730	1	1
[5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol	Homo sapiens (human)	IC50	4.4200	1	1
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)	Homo sapiens (human)	IC50	0.0550	4	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sb 202190	Homo sapiens (human)	Kd	10.0000	1	1
imatinib	Homo sapiens (human)	Kd	10.0000	2	2
triciribine phosphate	Homo sapiens (human)	Kd	30.0000	1	1
staurosporine	Homo sapiens (human)	Kd	0.0280	2	2
gefitinib	Homo sapiens (human)	Kd	10.0000	2	2
lestaurtinib	Homo sapiens (human)	Kd	0.0290	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	2	2
ruboxistaurin	Homo sapiens (human)	Kd	5.4000	2	2
canertinib	Homo sapiens (human)	Kd	16.6667	3	3
birb 796	Homo sapiens (human)	Kd	10.0000	2	2
cyc 202	Homo sapiens (human)	Kd	1.1000	1	1
sb 203580	Homo sapiens (human)	Kd	10.0000	2	2
enzastaurin	Homo sapiens (human)	Kd	1.0000	1	1
erlotinib	Homo sapiens (human)	Kd	16.6667	3	3
lapatinib	Homo sapiens (human)	Kd	10.0000	2	2
sorafenib	Homo sapiens (human)	Kd	15.0000	4	4
pd 173955	Homo sapiens (human)	Kd	10.0000	1	1
s 1033	Homo sapiens (human)	Kd	10.0000	1	1
tg 003	Homo sapiens (human)	Kd	0.1300	1	1
bms 387032	Homo sapiens (human)	Kd	0.2000	2	2
sf 2370	Homo sapiens (human)	Kd	30.0000	1	1
tandutinib	Homo sapiens (human)	Kd	10.0000	3	3
vx-745	Homo sapiens (human)	Kd	10.0000	2	2
dasatinib	Homo sapiens (human)	Kd	10.0000	2	2
zd 6474	Homo sapiens (human)	Kd	10.0000	2	2
ml106	Homo sapiens (human)	Kd	0.4300	1	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
sirolimus	Homo sapiens (human)	Kd	30.0000	1	1
alvocidib	Homo sapiens (human)	Kd	0.0840	2	2
bosutinib	Homo sapiens (human)	Kd	10.0000	1	1
su 11248	Homo sapiens (human)	Kd	2.3000	3	3
palbociclib	Homo sapiens (human)	Kd	30.0000	1	1
jnj-7706621	Homo sapiens (human)	Kd	10.0000	1	1
vx680	Homo sapiens (human)	Kd	10.0000	2	2
ekb 569	Homo sapiens (human)	Kd	4.0000	1	1
axitinib	Homo sapiens (human)	Kd	10.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
av 412	Homo sapiens (human)	Kd	30.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	0.3300	3	3
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
cp 724714	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	7.8500	2	2
hki 272	Homo sapiens (human)	Kd	10.0000	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	2	2
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	10.0000	1	1
masitinib	Homo sapiens (human)	Kd	20.0000	2	2
ly-2157299	Homo sapiens (human)	Kd	30.0000	1	1
pazopanib	Homo sapiens (human)	Kd	10.0000	2	2
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	2.6000	2	2
bibw 2992	Homo sapiens (human)	Kd	2.8000	1	1
tg100-115	Homo sapiens (human)	Kd	15.3650	2	2
cc 401	Homo sapiens (human)	Kd	30.0000	1	1
pha 665752	Homo sapiens (human)	Kd	10.0000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	10.0000	1	1
brivanib	Homo sapiens (human)	Kd	20.0000	2	2
rgb 286638	Homo sapiens (human)	Kd	30.0000	1	2
at 7519	Homo sapiens (human)	Kd	0.2900	1	1
bi 2536	Homo sapiens (human)	Kd	10.0000	1	1
inno-406	Homo sapiens (human)	Kd	30.0000	1	2
nvp-ast487	Homo sapiens (human)	Kd	10.0000	2	2
kw 2449	Homo sapiens (human)	Kd	15.4700	2	2
abt 869	Homo sapiens (human)	Kd	16.6667	3	3
ridaforolimus	Homo sapiens (human)	Kd	1.2620	1	1
cc-930	Homo sapiens (human)	Kd	30.0000	1	1
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
idelalisib	Homo sapiens (human)	Kd	30.0000	1	1
crizotinib	Homo sapiens (human)	Kd	20.0000	2	2
chir-265	Homo sapiens (human)	Kd	10.0000	2	2
motesanib	Homo sapiens (human)	Kd	10.0000	2	2
fostamatinib	Homo sapiens (human)	Kd	30.0000	1	1
trametinib	Homo sapiens (human)	Kd	30.0000	1	1
mln8054	Homo sapiens (human)	Kd	10.0000	2	2
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
tg100801	Homo sapiens (human)	Kd	30.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	10.0000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	10.0000	2	2
nvp-tae684	Homo sapiens (human)	Kd	4.5000	1	1
e 7050	Homo sapiens (human)	Kd	30.0000	1	1
fedratinib	Homo sapiens (human)	Kd	9.5000	1	1
gsk690693	Homo sapiens (human)	Kd	10.0000	1	1
azd5438	Homo sapiens (human)	Kd	30.0000	1	1
pf 04217903	Homo sapiens (human)	Kd	30.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	16.9000	2	2
icotinib	Homo sapiens (human)	Kd	30.0000	1	1
kx-01	Homo sapiens (human)	Kd	30.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
mk 5108	Homo sapiens (human)	Kd	30.0000	1	1
mln 8237	Homo sapiens (human)	Kd	30.0000	1	1
sgx 523	Homo sapiens (human)	Kd	20.6000	2	3
pci 32765	Homo sapiens (human)	Kd	30.0000	1	1
AMG-208	Homo sapiens (human)	Kd	30.0000	1	1
quizartinib	Homo sapiens (human)	Kd	10.0000	2	2
mk 2206	Homo sapiens (human)	Kd	30.0000	1	1
sns 314	Homo sapiens (human)	Kd	30.0000	1	1
cabozantinib	Homo sapiens (human)	Kd	30.0000	1	1
defactinib	Homo sapiens (human)	Kd	30.0000	1	1
incb-018424	Homo sapiens (human)	Kd	10.0000	1	1
TAK-580	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	0.9700	1	1
azd2014	Homo sapiens (human)	Kd	30.0000	1	1
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	Homo sapiens (human)	Kd	30.0000	1	1
plx4032	Homo sapiens (human)	Kd	30.0000	1	2
gsk 1363089	Homo sapiens (human)	Kd	20.0000	2	2
dabrafenib	Homo sapiens (human)	Kd	30.0000	1	1
mk-8033	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1070916	Homo sapiens (human)	Kd	30.0000	1	2
alectinib	Homo sapiens (human)	Kd	30.0000	1	1
encorafenib	Homo sapiens (human)	Kd	30.0000	1	1
ceritinib	Homo sapiens (human)	Kd	30.0000	1	1
chir 258	Homo sapiens (human)	Kd	10.0000	2	2
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)	Homo sapiens (human)	Kd	0.1400	1	1
nintedanib	Homo sapiens (human)	Kd	1.6000	1	1
bay 80-6946	Homo sapiens (human)	Kd	30.0000	1	1
pp242	Homo sapiens (human)	Kd	10.0000	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
transcription coactivator activity	molecular function	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
protein kinase activity	molecular function	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
protein serine/threonine/tyrosine kinase activity	molecular function	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah]
protein tyrosine kinase activity	molecular function	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
chromosome	cellular component	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684]
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
DNA repair	biological process	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
myoblast fusion	biological process	A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
adipose tissue development	biological process	The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. [GOC:dph]
peptidyl-serine phosphorylation	biological process	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]
peptidyl-threonine phosphorylation	biological process	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038]

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