Proteins > Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Page last updated: 2024-08-07 18:54:02

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y463]

Synonyms

EC 2.7.12.1;
Minibrain-related kinase;
Mirk protein kinase

Research

Bioassay Publications (21)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (14.29)29.6817
2010's16 (76.19)24.3611
2020's2 (9.52)2.80

Compounds (124)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.001733
cyc 202Homo sapiens (human)IC501.200011
ml106Homo sapiens (human)IC500.697011
6-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamineHomo sapiens (human)IC500.452011
harmineHomo sapiens (human)IC500.118355
harmineHomo sapiens (human)Ki0.166011
as 605240Homo sapiens (human)IC500.080011
leucettamine bHomo sapiens (human)IC502.850022
cx 4945Homo sapiens (human)IC500.006433
6-(1,3-benzodioxol-5-yl)-N-methyl-N-(thiophen-2-ylmethyl)-4-quinazolinamineHomo sapiens (human)IC500.073011
[5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanolHomo sapiens (human)IC504.420011
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)Homo sapiens (human)IC500.055044

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd10.000022
triciribine phosphateHomo sapiens (human)Kd30.000011
staurosporineHomo sapiens (human)Kd0.028022
gefitinibHomo sapiens (human)Kd10.000022
lestaurtinibHomo sapiens (human)Kd0.029022
vatalanibHomo sapiens (human)Kd10.000022
ruboxistaurinHomo sapiens (human)Kd5.400022
canertinibHomo sapiens (human)Kd16.666733
birb 796Homo sapiens (human)Kd10.000022
cyc 202Homo sapiens (human)Kd1.100011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd1.000011
erlotinibHomo sapiens (human)Kd16.666733
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd15.000044
pd 173955Homo sapiens (human)Kd10.000011
s 1033Homo sapiens (human)Kd10.000011
tg 003Homo sapiens (human)Kd0.130011
bms 387032Homo sapiens (human)Kd0.200022
sf 2370Homo sapiens (human)Kd30.000011
tandutinibHomo sapiens (human)Kd10.000033
vx-745Homo sapiens (human)Kd10.000022
dasatinibHomo sapiens (human)Kd10.000022
zd 6474Homo sapiens (human)Kd10.000022
ml106Homo sapiens (human)Kd0.430011
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
sirolimusHomo sapiens (human)Kd30.000011
alvocidibHomo sapiens (human)Kd0.084022
bosutinibHomo sapiens (human)Kd10.000011
su 11248Homo sapiens (human)Kd2.300033
palbociclibHomo sapiens (human)Kd30.000011
jnj-7706621Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd10.000022
ekb 569Homo sapiens (human)Kd4.000011
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
av 412Homo sapiens (human)Kd30.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd0.330033
ki 20227Homo sapiens (human)Kd10.000011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd7.850022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd10.000011
masitinibHomo sapiens (human)Kd20.000022
ly-2157299Homo sapiens (human)Kd30.000011
pazopanibHomo sapiens (human)Kd10.000022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd2.600022
bibw 2992Homo sapiens (human)Kd2.800011
tg100-115Homo sapiens (human)Kd15.365022
cc 401Homo sapiens (human)Kd30.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd10.000011
brivanibHomo sapiens (human)Kd20.000022
rgb 286638Homo sapiens (human)Kd30.000012
at 7519Homo sapiens (human)Kd0.290011
bi 2536Homo sapiens (human)Kd10.000011
inno-406Homo sapiens (human)Kd30.000012
nvp-ast487Homo sapiens (human)Kd10.000022
kw 2449Homo sapiens (human)Kd15.470022
abt 869Homo sapiens (human)Kd16.666733
ridaforolimusHomo sapiens (human)Kd1.262011
cc-930Homo sapiens (human)Kd30.000011
gw 2580Homo sapiens (human)Kd10.000022
idelalisibHomo sapiens (human)Kd30.000011
crizotinibHomo sapiens (human)Kd20.000022
chir-265Homo sapiens (human)Kd10.000022
motesanibHomo sapiens (human)Kd10.000022
fostamatinibHomo sapiens (human)Kd30.000011
trametinibHomo sapiens (human)Kd30.000011
mln8054Homo sapiens (human)Kd10.000022
GDC-0879Homo sapiens (human)Kd10.000011
tg100801Homo sapiens (human)Kd30.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd10.000022
nvp-tae684Homo sapiens (human)Kd4.500011
e 7050Homo sapiens (human)Kd30.000011
fedratinibHomo sapiens (human)Kd9.500011
gsk690693Homo sapiens (human)Kd10.000011
azd5438Homo sapiens (human)Kd30.000011
pf 04217903Homo sapiens (human)Kd30.000011
gdc 0941Homo sapiens (human)Kd16.900022
icotinibHomo sapiens (human)Kd30.000011
kx-01Homo sapiens (human)Kd30.000011
plx 4720Homo sapiens (human)Kd10.000011
mk 5108Homo sapiens (human)Kd30.000011
mln 8237Homo sapiens (human)Kd30.000011
sgx 523Homo sapiens (human)Kd20.600023
pci 32765Homo sapiens (human)Kd30.000011
AMG-208Homo sapiens (human)Kd30.000011
quizartinibHomo sapiens (human)Kd10.000022
mk 2206Homo sapiens (human)Kd30.000011
sns 314Homo sapiens (human)Kd30.000011
cabozantinibHomo sapiens (human)Kd30.000011
defactinibHomo sapiens (human)Kd30.000011
incb-018424Homo sapiens (human)Kd10.000011
TAK-580Homo sapiens (human)Kd30.000011
gsk 1838705aHomo sapiens (human)Kd0.970011
azd2014Homo sapiens (human)Kd30.000011
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanolHomo sapiens (human)Kd30.000011
plx4032Homo sapiens (human)Kd30.000012
gsk 1363089Homo sapiens (human)Kd20.000022
dabrafenibHomo sapiens (human)Kd30.000011
mk-8033Homo sapiens (human)Kd30.000011
gsk 1070916Homo sapiens (human)Kd30.000012
alectinibHomo sapiens (human)Kd30.000011
encorafenibHomo sapiens (human)Kd30.000011
ceritinibHomo sapiens (human)Kd30.000011
chir 258Homo sapiens (human)Kd10.000022
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)Homo sapiens (human)Kd0.140011
nintedanibHomo sapiens (human)Kd1.600011
bay 80-6946Homo sapiens (human)Kd30.000011
pp242Homo sapiens (human)Kd10.000011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
transcription coactivator activitymolecular functionA transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
protein kinase activitymolecular functionCatalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
protein serine/threonine/tyrosine kinase activitymolecular functionCatalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah]
protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein serine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]
protein serine/threonine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
chromosomecellular componentA structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684]
nucleoluscellular componentA small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
DNA repairbiological processThe process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]
myoblast fusionbiological processA process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:mtg_muscle]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
adipose tissue developmentbiological processThe process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. [GOC:dph]
peptidyl-serine phosphorylationbiological processThe phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]
peptidyl-threonine phosphorylationbiological processThe phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038]