Proteins > Bromodomain-containing protein 2
Page last updated: 2024-08-07 23:23:36

Bromodomain-containing protein 2

A bromodomain-containing protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25440]

Synonyms

O27.1.1;
Really interesting new gene 3 protein

Research

Bioassay Publications (31)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's19 (61.29)24.3611
2020's12 (38.71)2.80

Compounds (11)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ly 303511Homo sapiens (human)IC507.400011
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-oneHomo sapiens (human)IC5010.300011
prazosinHomo sapiens (human)IC500.000911
prazosinHomo sapiens (human)Ki0.000611
6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)-Homo sapiens (human)IC500.060544
6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)-Homo sapiens (human)Ki0.014666
jq1 compoundHomo sapiens (human)IC500.09592220
jq1 compoundHomo sapiens (human)Ki0.012844
gsk525762aHomo sapiens (human)IC500.363055
gsk525762aHomo sapiens (human)Ki0.082544
LSM-6732Homo sapiens (human)IC500.050844
gsk1210151aHomo sapiens (human)IC500.312744
gsk1210151aHomo sapiens (human)Ki0.029322
i-bet726Homo sapiens (human)IC505.488856
MZ1Homo sapiens (human)IC500.718522
MZ1Homo sapiens (human)Ki0.161022
rvx 208Homo sapiens (human)IC502.993544

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
jq1 compoundHomo sapiens (human)Kd0.08271211
gsk525762aHomo sapiens (human)Kd0.104088
gsk1210151aHomo sapiens (human)Kd0.062622
i-bet726Homo sapiens (human)Kd0.025011
rvx 208Homo sapiens (human)Kd4.12681010

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
protein serine/threonine kinase activitymolecular functionCatalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
lysine-acetylated histone bindingmolecular functionBinding to a histone in which a lysine residue has been modified by acetylation. [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]
acetylation-dependent protein bindingmolecular functionBinding to a protein upon acetylation of the target protein. [PMID:26060076]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nuclear speckcellular componentA discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
neural tube closurebiological processThe last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. [GOC:dph, ISBN:0878932437]
nucleosome assemblybiological processThe aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. [GOC:mah]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
spermatogenesisbiological processThe developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
protein localization to chromatinbiological processAny process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. [GOC:mah]
chromatin loopingbiological processA chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome. [PMID:32213323]
positive regulation of T-helper 17 cell lineage commitmentbiological processAny process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment. [GOC:BHF, GOC:mah]