Dihydropteridine reductase

A dihydropteridine reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09417]

EC 1.5.1.34;
HDHPR;
Quinoid dihydropteridine reductase;
Short chain dehydrogenase/reductase family 33C member 1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Homo sapiens (human)	IC50	5,100.0000	2	2
4-phenylpyridine	Homo sapiens (human)	IC50	2,400.0000	1	1
1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine	Homo sapiens (human)	IC50	2,700.0000	1	1
4-phenyl-1,2,3,6-tetrahydropyridine	Homo sapiens (human)	IC50	12,000.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
6,7-dihydropteridine reductase activity	molecular function	Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. [EC:1.5.1.34]
electron transfer activity	molecular function	A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer]
NADH binding	molecular function	Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]
NADPH binding	molecular function	Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]

This protein is located in 3 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 4 target(s):

Target	Category	Definition
amino acid metabolic process	biological process	The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. [ISBN:0198506732]
dihydrobiopterin metabolic process	biological process	The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions. [PMID:2557335]
tetrahydrobiopterin biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. [ISBN:0198506732]
L-phenylalanine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. [GOC:go_curators]