Page last updated: 2024-08-07 16:45:51
Thromboxane-A synthase
A thromboxane-A synthase that is encoded in the genome of rat. [OMA:P49430, PRO:DNx]
Synonyms
TXA synthase;
TXS;
EC 5.3.99.5;
Cytochrome P450 5A1;
Hydroperoxy icosatetraenoate dehydratase;
4.2.1.152
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (16)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sulotroban | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| dazoxiben | Rattus norvegicus (Norway rat) | IC50 | 0.9512 | 5 | 5 |
| dazmegrel | Rattus norvegicus (Norway rat) | IC50 | 0.0280 | 1 | 1 |
| zileuton | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| cgs 22652 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 1 | 2 |
| beta-naphthamidine | Rattus norvegicus (Norway rat) | Ki | 7.8000 | 1 | 1 |
| e 3040 | Rattus norvegicus (Norway rat) | IC50 | 0.0900 | 1 | 1 |
| ozagrel | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| ridogrel | Rattus norvegicus (Norway rat) | IC50 | 0.0060 | 1 | 2 |
| 6-(4-(2-(((4-chlorophenyl)sulfonyl)amino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| amprenavir | Rattus norvegicus (Norway rat) | IC90 | 0.0460 | 1 | 1 |
| dmp 323 | Rattus norvegicus (Norway rat) | IC90 | 0.1146 | 1 | 1 |
| dmp 450 | Rattus norvegicus (Norway rat) | IC90 | 0.1250 | 1 | 1 |
| ritonavir | Rattus norvegicus (Norway rat) | IC90 | 0.0760 | 1 | 1 |
| saquinavir | Rattus norvegicus (Norway rat) | IC90 | 0.0104 | 1 | 1 |
| indinavir sulfate | Rattus norvegicus (Norway rat) | IC90 | 0.0500 | 1 | 1 |