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Thromboxane-A synthase
A thromboxane-A synthase that is encoded in the genome of rat. [OMA:P49430, PRO:DNx]
Synonyms
TXA synthase;
TXS;
EC 5.3.99.5;
Cytochrome P450 5A1;
Hydroperoxy icosatetraenoate dehydratase;
4.2.1.152
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (16)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amprenavir | Rattus norvegicus (Norway rat) | IC90 | 0.0460 | 1 | 1 |
| dmp 323 | Rattus norvegicus (Norway rat) | IC90 | 0.1146 | 1 | 1 |
| dmp 450 | Rattus norvegicus (Norway rat) | IC90 | 0.1250 | 1 | 1 |
| ritonavir | Rattus norvegicus (Norway rat) | IC90 | 0.0760 | 1 | 1 |
| saquinavir | Rattus norvegicus (Norway rat) | IC90 | 0.0104 | 1 | 1 |
| indinavir sulfate | Rattus norvegicus (Norway rat) | IC90 | 0.0500 | 1 | 1 |
Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:6, 1987
Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones.Journal of medicinal chemistry, , Volume: 30, Issue:12, 1987
Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-1,2,4-triazol-1-yl)alkyl]aryl amides.Journal of medicinal chemistry, , Volume: 29, Issue:4, 1986
Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents.Journal of medicinal chemistry, , Volume: 29, Issue:5, 1986