Page last updated: 2024-08-07 16:02:59
ATP-citrate synthase
An ATP-citrate synthase that is encoded in the genome of rat. [OMA:P16638, PRO:DNx]
Synonyms
EC 2.3.3.8;
ATP-citrate (pro-S-)-lyase;
Citrate cleavage enzyme
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| itaconic acid | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| glutamic acid | Rattus norvegicus (Norway rat) | Ki | 300.0000 | 1 | 1 |
| medica 16 | Rattus norvegicus (Norway rat) | Ki | 11.6667 | 3 | 3 |
| hydroxycitric acid | Rattus norvegicus (Norway rat) | Ki | 4.0750 | 4 | 4 |
| aconitic acid | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| aconitic acid | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| monorden | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 4 | 4 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| citric acid, anhydrous | Rattus norvegicus (Norway rat) | Km | 110.0000 | 1 | 2 |
ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
The lipogenesis pathway as a cancer target.Journal of medicinal chemistry, , Aug-25, Volume: 54, Issue:16, 2011
Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based inhibitors of ATP citrate lyase.Journal of medicinal chemistry, , Feb-03, Volume: 38, Issue:3, 1995