Cytochrome P450 4A22

A cytochrome P450 4A22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TCH4]

CYPIVA22;
Fatty acid omega-hydroxylase;
Lauric acid omega-hydroxylase;
Long-chain fatty acid omega-monooxygenase;
1.14.14.80

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tranylcypromine	Homo sapiens (human)	IC50	6.2000	1	1
proadifen hydrochloride	Homo sapiens (human)	IC50	19.0000	1	1
pirlindole	Homo sapiens (human)	IC50	36.0000	1	1
kaf156	Homo sapiens (human)	IC50	6.0000	1	1

This protein enables 7 target(s):

Target	Category	Definition
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
long-chain fatty acid omega-hydroxylase activity	molecular function	Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, PMID:18544608, RHEA:56748]
16-hydroxypalmitate dehydrogenase activity	molecular function	Catalysis of the reaction: 16-hydroxypalmitate + NADP = H+ + 16-oxo-palmitate + NADPH. [GOC:pz]
medium-chain fatty acid omega-hydroxylase activity	molecular function	Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [PMID:35934685, RHEA:75279]
arachidonic acid monooxygenase activity	molecular function	Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. [GOC:mah]
alkane 1-monooxygenase activity	molecular function	Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. [EC:1.14.15.3]

This protein is located in 2 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is active in 1 target(s):

Target	Category	Definition
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

This protein is involved in 6 target(s):

Target	Category	Definition
lipid hydroxylation	biological process	The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. [GOC:hjd, PMID:15658937]
linoleic acid metabolic process	biological process	The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. [Wikipedia:Linoleic_Acid]
lauric acid metabolic process	biological process	The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources. [GOC:jid, PMID:15555597]
arachidonic acid metabolic process	biological process	The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732]
kidney development	biological process	The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
icosanoid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. [ISBN:0198506732]