Estrogen receptor

An estrogen receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P03372]

Synonyms

ER;
ER-alpha;
Estradiol receptor;
Nuclear receptor subfamily 3 group A member 1

Research

Bioassay Publications (208)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	14 (6.73)	18.2507
2000's	99 (47.60)	29.6817
2010's	76 (36.54)	24.3611
2020's	19 (9.13)	2.80

Compounds (123)

Drugs with Potency Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mifepristone	Homo sapiens (human)	Potency	1.0000	1	1
onapristone	Homo sapiens (human)	Potency	1.0000	1	1

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
naringenin	Homo sapiens (human)	IC50	42.8875	1	2
4-nonylphenol	Homo sapiens (human)	IC50	0.3770	1	0
4-nonylphenol	Homo sapiens (human)	Ki	0.1080	1	0
bicalutamide	Homo sapiens (human)	Ki	100.0000	1	1
cyclofenil	Homo sapiens (human)	IC50	0.0270	1	1
stallimycin	Homo sapiens (human)	IC50	0.0200	1	1
emodin	Homo sapiens (human)	IC50	2.7000	1	1
emodin	Homo sapiens (human)	Ki	0.7700	1	1
letrozole	Homo sapiens (human)	IC50	10.0000	1	1
phloretin	Homo sapiens (human)	IC50	0.3000	1	1
raloxifene	Homo sapiens (human)	IC50	0.0427	47	49
raloxifene	Homo sapiens (human)	Ki	0.0007	9	9
prednisolone	Homo sapiens (human)	IC50	55.0000	2	2
prednisolone	Homo sapiens (human)	Ki	3.6667	3	3
estriol	Homo sapiens (human)	IC50	0.0017	1	0
estriol	Homo sapiens (human)	Ki	0.0005	1	0
spironolactone	Homo sapiens (human)	IC50	12.8510	2	2
spironolactone	Homo sapiens (human)	Ki	1.1000	1	1
estrone	Homo sapiens (human)	IC50	0.1261	6	6
estrone	Homo sapiens (human)	Ki	0.0022	1	0
ethinyl estradiol	Homo sapiens (human)	IC50	0.0035	3	2
ethinyl estradiol	Homo sapiens (human)	Ki	0.0001	1	0
norethindrone	Homo sapiens (human)	IC50	0.8080	1	0
norethindrone	Homo sapiens (human)	Ki	0.2310	1	0
medroxyprogesterone acetate	Homo sapiens (human)	IC50	0.9240	2	2
mestranol	Homo sapiens (human)	IC50	0.0180	1	0
mestranol	Homo sapiens (human)	Ki	0.0052	1	0
3,3'-Dimethylbisphenol A	Homo sapiens (human)	IC50	0.8437	3	3
bisphenol a	Homo sapiens (human)	IC50	3.4198	4	3
bisphenol a	Homo sapiens (human)	Ki	0.6490	1	0
2,6-dihydroxyanthraquinone	Homo sapiens (human)	IC50	1.1000	1	1
2,6-dihydroxyanthraquinone	Homo sapiens (human)	Ki	0.3100	1	1
butylparaben	Homo sapiens (human)	IC50	1.4200	1	1
androstenediol	Homo sapiens (human)	IC50	0.1950	2	2
4-cumylphenol	Homo sapiens (human)	IC50	24.0000	1	1
4,4'-bisphenol f	Homo sapiens (human)	IC50	5.7135	2	2
ethylestrenol	Homo sapiens (human)	IC50	1.1210	1	0
ethylestrenol	Homo sapiens (human)	Ki	0.3200	1	0
n-butyl gallate	Homo sapiens (human)	IC50	8.9700	1	1
4-octylphenol	Homo sapiens (human)	IC50	27.6740	1	0
4-octylphenol	Homo sapiens (human)	Ki	7.9070	1	0
stanozolol	Homo sapiens (human)	IC50	0.1130	1	0
stanozolol	Homo sapiens (human)	Ki	0.0320	1	0
danazol	Homo sapiens (human)	IC50	17.7900	1	0
danazol	Homo sapiens (human)	Ki	5.0830	1	0
levormeloxifene	Homo sapiens (human)	IC50	0.0730	1	1
raloxifene hydrochloride	Homo sapiens (human)	IC50	0.0053	6	6
mifepristone	Homo sapiens (human)	IC50	6.6102	8	7
mifepristone	Homo sapiens (human)	Ki	6.7385	4	3
octyl gallate	Homo sapiens (human)	IC50	8.7400	1	1
1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene	Homo sapiens (human)	IC50	0.0061	3	3
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	IC50	0.4554	22	22
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	Ki	0.0012	8	8
alfatradiol	Homo sapiens (human)	IC50	0.5700	1	1
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	Homo sapiens (human)	IC50	0.0434	1	1
equol	Homo sapiens (human)	IC50	5.8760	1	1
anthraglycoside b	Homo sapiens (human)	IC50	20.0000	1	1
anthraglycoside b	Homo sapiens (human)	Ki	5.7000	1	1
effusol	Homo sapiens (human)	IC50	0.2400	1	1
fulvestrant	Homo sapiens (human)	IC50	0.0061	31	31
fulvestrant	Homo sapiens (human)	Ki	0.0031	3	3
ici 164384	Homo sapiens (human)	IC50	0.1950	2	2
ici 164384	Homo sapiens (human)	Ki	0.0029	3	3
ly 117018	Homo sapiens (human)	IC50	0.1200	1	1
ru 39411	Homo sapiens (human)	Ki	0.0415	1	1
zk 119010	Homo sapiens (human)	IC50	0.0470	2	2
bazedoxifene	Homo sapiens (human)	IC50	7.9343	4	4
ly 353381	Homo sapiens (human)	IC50	0.0378	3	4
lasofoxifene	Homo sapiens (human)	IC50	0.0046	8	10
estradiol 3-benzoate	Homo sapiens (human)	IC50	0.0650	1	0
estradiol 3-benzoate	Homo sapiens (human)	Ki	0.0180	1	0
1,1-bis(4-hydroxyphenyl)cyclohexane	Homo sapiens (human)	IC50	0.5200	1	1
4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en	Homo sapiens (human)	IC50	0.0331	1	1
naringenin	Homo sapiens (human)	IC50	75.3020	1	1
2-methoxyestrone	Homo sapiens (human)	IC50	11.0000	1	1
davidigenin	Homo sapiens (human)	IC50	1,000.0000	1	1
eplerenone	Homo sapiens (human)	IC50	15.0000	2	2
tibolone	Homo sapiens (human)	IC50	0.4333	1	0
tibolone	Homo sapiens (human)	Ki	0.1238	1	0
fluticasone propionate	Homo sapiens (human)	IC50	10.0000	1	1
resveratrol	Homo sapiens (human)	Ki	0.5797	2	3
diethylstilbestrol	Homo sapiens (human)	IC50	0.1312	6	5
diethylstilbestrol	Homo sapiens (human)	Ki	0.0002	5	4
afimoxifene	Homo sapiens (human)	IC50	0.0105	14	16
8-prenylnaringenin	Homo sapiens (human)	IC50	0.0625	1	2
8-isopentenylnaringenin	Homo sapiens (human)	IC50	0.0570	1	1
1,1-Bis(4-hydroxyphenyl)ethane	Homo sapiens (human)	IC50	6.1600	1	1
isoliquiritigenin	Homo sapiens (human)	IC50	1.8700	1	1
erb 041	Homo sapiens (human)	IC50	1.2160	1	1
enclomiphene	Homo sapiens (human)	IC50	0.0046	1	0
enclomiphene	Homo sapiens (human)	Ki	0.0013	1	0
tamoxifen citrate	Homo sapiens (human)	IC50	1.7000	1	1
tamoxifen	Homo sapiens (human)	IC50	1.1796	41	41
tamoxifen	Homo sapiens (human)	Ki	0.0586	4	4
idoxifene	Homo sapiens (human)	IC50	0.0075	1	1
4-hydroxytoremifene	Homo sapiens (human)	IC50	0.0070	2	3
N-[2-(2-methyl-1-indolyl)ethyl]benzamide	Homo sapiens (human)	IC50	32.7000	1	0
apigenin	Homo sapiens (human)	IC50	7.6265	2	2
genistein	Homo sapiens (human)	IC50	1.3477	23	24
genistein	Homo sapiens (human)	Ki	0.2045	2	1
pulmicort	Homo sapiens (human)	IC50	10.0000	1	1
coumestrol	Homo sapiens (human)	IC50	0.0434	2	2
daidzein	Homo sapiens (human)	IC50	175.4267	6	6
daidzein	Homo sapiens (human)	Ki	1.8000	1	1
caffeic acid phenethyl ester	Homo sapiens (human)	IC50	7.9120	1	0
caffeic acid phenethyl ester	Homo sapiens (human)	Ki	2.2600	1	0
afimoxifene	Homo sapiens (human)	IC50	0.0506	2	2
gw 5638	Homo sapiens (human)	IC50	10.9408	11	11
onapristone	Homo sapiens (human)	IC50	1.0000	2	2
onapristone	Homo sapiens (human)	Ki	0.0200	1	1
broussonin a	Homo sapiens (human)	IC50	8.1000	1	1
1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone	Homo sapiens (human)	Ki	10.0000	2	2
ly2066948	Homo sapiens (human)	Ki	0.0008	2	3
afimoxifene	Homo sapiens (human)	IC50	0.0023	2	2
dehydrodiconiferyl alcohol	Homo sapiens (human)	IC50	0.0619	1	1
3,4',5-trimethoxystilbene	Homo sapiens (human)	Ki	0.1766	2	3
way 202196	Homo sapiens (human)	IC50	0.2100	1	1
era-923	Homo sapiens (human)	IC50	0.0078	2	2
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	IC50	33.5000	2	2
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	Ki	5.0000	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	IC50	5.0000	1	1
pregna-4,17-diene-3,16-dione, (17z)-isomer	Homo sapiens (human)	Ki	5.0000	1	1
gsk5182	Homo sapiens (human)	IC50	1.0618	4	5
ru 58668	Homo sapiens (human)	IC50	0.0000	1	1
asoprisnil	Homo sapiens (human)	IC50	1.9500	2	2
gw 7604	Homo sapiens (human)	IC50	2.3514	13	13
gw 7604	Homo sapiens (human)	Ki	0.0025	1	1
fluticasone furoate	Homo sapiens (human)	IC50	5.0000	1	1
em 800	Homo sapiens (human)	IC50	0.0007	2	2
em 800	Homo sapiens (human)	Ki	0.0040	4	4
way-362450	Homo sapiens (human)	IC50	10.0000	1	1
4-hydroxy-n-desmethyltamoxifen	Homo sapiens (human)	IC50	0.0300	1	1
6-(3-hydroxyphenyl)-2-naphthol	Homo sapiens (human)	IC50	0.2300	1	1
erteberel	Homo sapiens (human)	Ki	0.0019	9	14
ly3201	Homo sapiens (human)	Ki	0.0057	4	6
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol	Homo sapiens (human)	Ki	1.5277	2	3
ridaifen-b	Homo sapiens (human)	IC50	0.0006	1	1
lgd 2226	Homo sapiens (human)	Ki	1.0000	1	1
y134 compound	Homo sapiens (human)	IC50	0.0003	2	2
moxestrol	Homo sapiens (human)	IC50	0.0027	2	2
nitd 609	Homo sapiens (human)	IC50	30.0000	1	1
pf-03882845	Homo sapiens (human)	IC50	10.0000	1	1
azd9496	Homo sapiens (human)	IC50	0.0004	7	8
way 200070	Homo sapiens (human)	IC50	0.1550	1	1
way-169916	Homo sapiens (human)	IC50	0.6965	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cyclofenil	Homo sapiens (human)	EC50	0.0260	1	1
raloxifene	Homo sapiens (human)	EC50	0.0149	3	3
spironolactone	Homo sapiens (human)	EC50	20.0000	1	1
estrone	Homo sapiens (human)	EC50	0.1100	6	6
ethinyl estradiol	Homo sapiens (human)	EC50	0.0252	2	2
medroxyprogesterone acetate	Homo sapiens (human)	EC50	0.9240	1	1
3,3'-Dimethylbisphenol A	Homo sapiens (human)	EC50	5.6910	2	2
bisphenol a	Homo sapiens (human)	EC50	3.1940	4	4
ethyl-p-hydroxybenzoate	Homo sapiens (human)	EC50	38.2000	1	1
androstenediol	Homo sapiens (human)	EC50	0.0260	2	2
4-cumylphenol	Homo sapiens (human)	EC50	4.4000	1	1
4,4'-bisphenol f	Homo sapiens (human)	EC50	3.9397	3	3
mifepristone	Homo sapiens (human)	EC50	10.0000	1	1
1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene	Homo sapiens (human)	EC50	0.0005	2	2
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	EC50	0.0082	3	3
alfatradiol	Homo sapiens (human)	EC50	0.2857	2	2
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	Homo sapiens (human)	EC50	0.0307	1	1
2,3-bis(4-hydroxyphenyl)-propionitrile	Homo sapiens (human)	EC50	1.6247	10	10
fulvestrant	Homo sapiens (human)	EC50	0.0007	3	3
fulvestrant	Homo sapiens (human)	Kd	0.0047	1	1
estrone-3-o-sulfamate	Homo sapiens (human)	EC50	2.6000	1	1
ly 353381	Homo sapiens (human)	EC50	0.0002	1	1
2-hydroxyestradiol	Homo sapiens (human)	EC50	1.0820	2	2
eplerenone	Homo sapiens (human)	EC50	20.0000	1	1
diethylstilbestrol	Homo sapiens (human)	EC50	0.0025	5	5
8-prenylnaringenin	Homo sapiens (human)	EC50	0.0060	2	2
isoxanthohumol	Homo sapiens (human)	EC50	1.4000	1	1
1,1-Bis(4-hydroxyphenyl)ethane	Homo sapiens (human)	EC50	10.0000	1	1
trans-4-coumaric acid	Homo sapiens (human)	EC50	16.1200	1	1
2,4,4'-trihydroxydeoxybenzoin	Homo sapiens (human)	EC50	2.0300	1	1
tamoxifen	Homo sapiens (human)	EC50	1.1568	3	5
(S)-4',5,7-Trihydroxy-6-prenylflavanone	Homo sapiens (human)	EC50	0.4000	1	1
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1h-pyrazole	Homo sapiens (human)	EC50	0.0014	3	3
genistein	Homo sapiens (human)	EC50	0.9980	6	6
4-hydroxyestradiol	Homo sapiens (human)	EC50	0.2857	2	2
gw 5638	Homo sapiens (human)	EC50	0.3900	2	2
broussonin a	Homo sapiens (human)	EC50	1.5900	1	1
era-923	Homo sapiens (human)	EC50	0.0001	1	1
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	EC50	100.0000	1	1
gw 7604	Homo sapiens (human)	EC50	0.0017	2	2
licoflavone c	Homo sapiens (human)	EC50	0.0500	1	1
erteberel	Homo sapiens (human)	EC50	0.0194	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
raloxifene	Homo sapiens (human)	Ka	0.0002	1	1
raloxifene	Homo sapiens (human)	Relative binding affinity	0.0180	1	1
estrone	Homo sapiens (human)	ED50	0.0510	1	1
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol	Homo sapiens (human)	Activity	0.0001	1	1
fulvestrant	Homo sapiens (human)	Activity	0.0001	1	1
fulvestrant	Homo sapiens (human)	DC50	0.0001	1	1
estrone-3-o-sulfamate	Homo sapiens (human)	ED50	2.6000	1	1
afimoxifene	Homo sapiens (human)	DC50	0.0001	1	1
tamoxifen	Homo sapiens (human)	DC50	0.0910	1	1
afimoxifene	Homo sapiens (human)	Ka	0.0002	1	1
ascochlorin	Homo sapiens (human)	MEC	1.0000	1	1

Enables

This protein enables 26 target(s):

Target	Category	Definition
RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
TFIIB-class transcription factor binding	molecular function	Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]
transcription coregulator binding	molecular function	Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. [GOC:krc]
transcription corepressor binding	molecular function	Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]
transcription coactivator binding	molecular function	Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. [GOC:krc]
DNA-binding transcription activator activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
DNA-binding transcription factor activity	molecular function	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]
nuclear receptor activity	molecular function	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
steroid binding	molecular function	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
beta-catenin binding	molecular function	Binding to a catenin beta subunit. [GOC:bf]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
TBP-class protein binding	molecular function	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
nitric-oxide synthase regulator activity	molecular function	Binds to and modulates the activity of nitric oxide synthase. [GOC:mah]
nuclear estrogen receptor activity	molecular function	Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. [GOC:signaling, PMID:17615392]
nuclear estrogen receptor binding	molecular function	Binding to a nuclear estrogen receptor. [GOC:ai]
estrogen response element binding	molecular function	Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
ATPase binding	molecular function	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]
14-3-3 protein binding	molecular function	Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]
sequence-specific double-stranded DNA binding	molecular function	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 4 target(s):

Target	Category	Definition
transcription regulator complex	cellular component	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
euchromatin	cellular component	A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. [PMID:32017156]
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 42 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
antral ovarian follicle growth	biological process	Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
epithelial cell development	biological process	The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. [GOC:dph]
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
regulation of DNA-templated transcription	biological process	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
androgen metabolic process	biological process	The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]
male gonad development	biological process	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
positive regulation of phospholipase C activity	biological process	Any process that increases the rate of phospholipase C activity. [GOC:dph, GOC:tb]
intracellular steroid hormone receptor signaling pathway	biological process	The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. [GOC:mah, GOC:signaling]
intracellular estrogen receptor signaling pathway	biological process	The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
response to estradiol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]
regulation of toll-like receptor signaling pathway	biological process	Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]
negative regulation of smooth muscle cell apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
negative regulation of canonical NF-kappaB signal transduction	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
negative regulation of DNA-binding transcription factor activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl]
response to estrogen	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:jl, ISBN:0198506732]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
fibroblast proliferation	biological process	The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. [GOC:jid]
positive regulation of fibroblast proliferation	biological process	Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. [GOC:jid]
stem cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [CL:0000034, GOC:isa_complete]
regulation of inflammatory response	biological process	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]
positive regulation of DNA-binding transcription factor activity	biological process	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]
RNA polymerase II preinitiation complex assembly	biological process	The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA. [GOC:txnOH, PMID:15020047, PMID:31300188]
uterus development	biological process	The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. [GOC:dph, GOC:ebc]
vagina development	biological process	The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. [GOC:dph, GOC:ebc]
prostate epithelial cord elongation	biological process	The developmental growth process in which solid chords of prostate epithelium increase in length. [GOC:dph, PMID:18977204]
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	biological process	The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini. [GOC:dph, PMID:18977204]
regulation of branching involved in prostate gland morphogenesis	biological process	Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. [GOC:dph]
mammary gland branching involved in pregnancy	biological process	The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy. [GOC:dph, PMID:19261859]
mammary gland alveolus development	biological process	The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. [GOC:dph]
epithelial cell proliferation involved in mammary gland duct elongation	biological process	The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth. [GOC:dph]
protein localization to chromatin	biological process	Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. [GOC:mah]
cellular response to estradiol stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah]
negative regulation of miRNA transcription	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
regulation of epithelial cell apoptotic process	biological process	Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
cellular response to estrogen stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. [GOC:mah]