A nicotinate phosphoribosyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6XQN6]
NAPRTase;
EC 6.3.4.21;
FHA-HIT-interacting protein;
Nicotinate phosphoribosyltransferase domain-containing protein 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0) | 18.7374 |
| 1990's | 0 (0) | 18.2507 |
| 2000's | 0 (0) | 29.6817 |
| 2010's | 0 (0) | 24.3611 |
| 2020's | 0 (0) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2-(3-pyridine)acetic acid | Homo sapiens (human) | Ki | 0.0013 | 1 | 0 |
| benzoic acid | Homo sapiens (human) | Ki | 0.0019 | 1 | 0 |
| salicylic acid | Homo sapiens (human) | Ki | 0.0002 | 1 | 0 |
| acetanilide | Homo sapiens (human) | Ki | 0.0010 | 1 | 0 |
| picolinic acid | Homo sapiens (human) | Ki | 0.0012 | 1 | 0 |
| pyrazinoic acid | Homo sapiens (human) | Ki | 0.0001 | 1 | 0 |
| pyridine | Homo sapiens (human) | Ki | 0.0008 | 1 | 0 |
| antipyrine | Homo sapiens (human) | Ki | 0.0010 | 1 | 0 |
| aspirin | Homo sapiens (human) | Ki | 0.0005 | 1 | 0 |
| flufenamic acid | Homo sapiens (human) | Ki | 0.0000 | 1 | 0 |
| indomethacin | Homo sapiens (human) | Ki | 0.0001 | 1 | 0 |
| mefenamic acid | Homo sapiens (human) | Ki | 0.0000 | 1 | 0 |
| oxyphenbutazone | Homo sapiens (human) | Ki | 0.0003 | 1 | 0 |
| phenylbutazone | Homo sapiens (human) | Ki | 0.0001 | 1 | 0 |
| sulfinpyrazone | Homo sapiens (human) | Ki | 0.0005 | 1 | 0 |
| isonicotinic acid | Homo sapiens (human) | Ki | 0.0008 | 1 | 0 |
| aminopyrine | Homo sapiens (human) | Ki | 0.0010 | 1 | 0 |
| 2-hydroxynicotinic acid | Homo sapiens (human) | Ki | 0.0002 | 1 | 0 |
| 2-aminonicotinic acid | Homo sapiens (human) | Ki | 0.0008 | 1 | 0 |
| 6-chloronicotinic acid | Homo sapiens (human) | Ki | 0.0006 | 1 | 0 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nicotinate phosphoribosyltransferase activity | molecular function | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate. [PMID:7503993] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| transferase activity | molecular function | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [ISBN:0198506732] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| azurophil granule lumen | cellular component | The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| response to oxidative stress | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731] |
| NAD salvage | biological process | Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam). [GOC:mah, PMID:12648681, PMID:27374990] |