Nicotinate phosphoribosyltransferase

A nicotinate phosphoribosyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6XQN6]

NAPRTase;
EC 6.3.4.21;
FHA-HIT-interacting protein;
Nicotinate phosphoribosyltransferase domain-containing protein 1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
2-(3-pyridine)acetic acid	Homo sapiens (human)	Ki	0.0013	1
benzoic acid	Homo sapiens (human)	Ki	0.0019	1
salicylic acid	Homo sapiens (human)	Ki	0.0002	1
acetanilide	Homo sapiens (human)	Ki	0.0010	1
picolinic acid	Homo sapiens (human)	Ki	0.0012	1
pyrazinoic acid	Homo sapiens (human)	Ki	0.0001	1
pyridine	Homo sapiens (human)	Ki	0.0008	1
antipyrine	Homo sapiens (human)	Ki	0.0010	1
aspirin	Homo sapiens (human)	Ki	0.0005	1
flufenamic acid	Homo sapiens (human)	Ki	0.0000	1
indomethacin	Homo sapiens (human)	Ki	0.0001	1
mefenamic acid	Homo sapiens (human)	Ki	0.0000	1
oxyphenbutazone	Homo sapiens (human)	Ki	0.0003	1
phenylbutazone	Homo sapiens (human)	Ki	0.0001	1
sulfinpyrazone	Homo sapiens (human)	Ki	0.0005	1
isonicotinic acid	Homo sapiens (human)	Ki	0.0008	1
aminopyrine	Homo sapiens (human)	Ki	0.0010	1
2-hydroxynicotinic acid	Homo sapiens (human)	Ki	0.0002	1
2-aminonicotinic acid	Homo sapiens (human)	Ki	0.0008	1
6-chloronicotinic acid	Homo sapiens (human)	Ki	0.0006	1

This protein enables 4 target(s):

Target	Category	Definition
nicotinate phosphoribosyltransferase activity	molecular function	Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate. [PMID:7503993]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
transferase activity	molecular function	Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 4 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
azurophil granule lumen	cellular component	The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 2 target(s):

Target	Category	Definition
response to oxidative stress	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
NAD salvage	biological process	Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam). [GOC:mah, PMID:12648681, PMID:27374990]