Proteins > Histone deacetylase 7
Page last updated: 2024-08-07 17:20:00

Histone deacetylase 7

A histone deacetylase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WUI4]

Synonyms

HD7;
EC 3.5.1.98;
Histone deacetylase 7A;
HD7a

Research

Bioassay Publications (246)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.41)18.2507
2000's57 (23.17)29.6817
2010's137 (55.69)24.3611
2020's51 (20.73)2.80

Compounds (81)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)Ki8.190011
butyric acidHomo sapiens (human)IC501,150.000022
butyric acidHomo sapiens (human)Ki136.000011
celecoxibHomo sapiens (human)IC501.637011
ci 994Homo sapiens (human)IC5023.2175512
ci 994Homo sapiens (human)Ki0.095013
clioquinolHomo sapiens (human)IC5071.0857114
valproic acidHomo sapiens (human)IC503,411.666733
valproic acidHomo sapiens (human)Ki564.000011
fluconazoleHomo sapiens (human)IC5040.000011
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)IC500.833022
entinostatHomo sapiens (human)IC509.54173047
4-phenylbutyric acidHomo sapiens (human)IC502,000.000011
4-phenylbutyric acidHomo sapiens (human)Ki2.800011
pomiferinHomo sapiens (human)IC501.050011
pyroxamideHomo sapiens (human)IC505.100022
scriptaidHomo sapiens (human)IC501.330022
scriptaidHomo sapiens (human)Ki2.250011
4-phenylbutyric acid, sodium saltHomo sapiens (human)Ki6.340011
fenofibrateHomo sapiens (human)IC5075.000011
vorinostatHomo sapiens (human)IC506.5889195223
vorinostatHomo sapiens (human)Ki1.299522
benzohydroxamic acidHomo sapiens (human)IC5015.600011
acetylcysteineHomo sapiens (human)IC503,160.000011
camptothecinHomo sapiens (human)IC500.050011
osajinHomo sapiens (human)IC506.530011
lapatinibHomo sapiens (human)IC50100.000011
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC508.955568
trapoxin aHomo sapiens (human)IC500.004733
e-z cinnamic acidHomo sapiens (human)Ki0.008211
trichostatin aHomo sapiens (human)IC500.50523757
trichostatin aHomo sapiens (human)Ki0.298033
caffeic acidHomo sapiens (human)IC502,540.000011
caffeic acidHomo sapiens (human)Ki10.840011
curcuminHomo sapiens (human)IC50187.000011
chlorogenic acidHomo sapiens (human)IC50258.333333
chlorogenic acidHomo sapiens (human)Ki0.135011
zd 6474Homo sapiens (human)IC5010.000033
desmethylanethol trithioneHomo sapiens (human)IC500.450022
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinolHomo sapiens (human)IC5025.195018
ex 527Homo sapiens (human)IC50100.000011
sodium butyrateHomo sapiens (human)IC50360.000033
sodium butyrateHomo sapiens (human)Ki365.000011
5'-o-caffeoylquinic acidHomo sapiens (human)IC50185.200022
harmineHomo sapiens (human)IC5010.000033
aureusidinHomo sapiens (human)IC5018.500011
romidepsinHomo sapiens (human)IC5010.062666
romidepsinHomo sapiens (human)Ki1.250022
3',4'-dihydroxyauroneHomo sapiens (human)IC508.200011
psammaplin aHomo sapiens (human)IC500.027022
trichostatin cHomo sapiens (human)IC5023.630011
laq824Homo sapiens (human)IC500.398766
laq824Homo sapiens (human)Ki9.500022
indigo carmineHomo sapiens (human)IC50321.620022
tanespimycinHomo sapiens (human)IC501,000.000011
pd 404182Homo sapiens (human)IC500.220011
tubacinHomo sapiens (human)IC509.700044
tubacinHomo sapiens (human)Ki6.963422
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC500.014077
belinostatHomo sapiens (human)IC500.035755
belinostatHomo sapiens (human)Ki0.067033
sk-7041Homo sapiens (human)IC500.172011
panobinostatHomo sapiens (human)IC501.85091321
panobinostatHomo sapiens (human)Ki2.433144
hdac-42Homo sapiens (human)IC500.223022
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)IC507.6678624
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Ki0.167213
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC50129.000022
bml 210Homo sapiens (human)IC5091.400055
n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamideHomo sapiens (human)IC501.060033
givinostatHomo sapiens (human)IC500.524011
givinostatHomo sapiens (human)Ki0.240022
mocetinostatHomo sapiens (human)IC507.3350514
methyl 3,5-di-o-caffeoyl quinateHomo sapiens (human)IC506.290022
r 306465Homo sapiens (human)IC500.026022
quisinostatHomo sapiens (human)IC500.042433
quisinostatHomo sapiens (human)Ki0.034222
abexinostatHomo sapiens (human)IC500.350011
chidamideHomo sapiens (human)IC505.789032
hc toxinHomo sapiens (human)IC500.430011
azumamide eHomo sapiens (human)IC509.700011
cnf 2024Homo sapiens (human)IC501.000022
pci 34051Homo sapiens (human)IC5036.670033
cudc 101Homo sapiens (human)IC500.208174
largazoleHomo sapiens (human)IC5010.000011
N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl esterHomo sapiens (human)IC500.050011
trichostatin rkHomo sapiens (human)IC50100.000011
jq1 compoundHomo sapiens (human)IC500.291011
tubastatin aHomo sapiens (human)IC5020.81151322
pracinostatHomo sapiens (human)IC505.063022
pracinostatHomo sapiens (human)Ki0.107011
acy-1215Homo sapiens (human)IC502.666799
cudc-907Homo sapiens (human)IC500.282855
rg2833Homo sapiens (human)IC50180.000011
mi-192Homo sapiens (human)IC504.100011
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)IC503.445044
osimertinibHomo sapiens (human)IC501.000011
santacruzamate aHomo sapiens (human)IC505.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ci 994Homo sapiens (human)EC503.810011
entinostatHomo sapiens (human)EC501.000011
imatinibHomo sapiens (human)EC50100.000011
vorinostatHomo sapiens (human)EC503.430066
vorinostatHomo sapiens (human)Kd36.000011
belinostatHomo sapiens (human)EC500.048522
kd 5170Homo sapiens (human)EC500.045011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)AC502.100011
pyroxamideHomo sapiens (human)AC507.900011
vorinostatHomo sapiens (human)AC503.100011
vorinostatHomo sapiens (human)INH0.188522
vorinostatHomo sapiens (human)Inhibition0.080011
trapoxin aHomo sapiens (human)AC500.010011
trichostatin aHomo sapiens (human)AC500.400011
trichostatin aHomo sapiens (human)Inhibition0.003511
romidepsinHomo sapiens (human)INH0.024411
largazoleHomo sapiens (human)INH0.572011

Enables

This protein enables 11 target(s):

TargetCategoryDefinition
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
transcription corepressor activitymolecular functionA transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
histone deacetylase activitymolecular functionCatalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]
protein kinase C bindingmolecular functionBinding to protein kinase C. [GOC:jl]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
SUMO transferase activitymolecular functionCatalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. [GOC:rn, PMID:11031248, PMID:11265250]
protein kinase bindingmolecular functionBinding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
protein lysine deacetylase activitymolecular functionCatalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
14-3-3 protein bindingmolecular functionBinding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]
DNA-binding transcription factor bindingmolecular functionBinding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 11 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
vasculogenesisbiological processThe differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. [PMID:8999798]
chromatin remodelingbiological processA dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
protein deacetylationbiological processThe removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]
cell-cell junction assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form a junction between cells. [GOC:ai]
protein sumoylationbiological processThe process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250]
negative regulation of interleukin-2 productionbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. [GOC:mah]
negative regulation of osteoblast differentiationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]
regulation of mRNA processingbiological processAny process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. [GOC:ai]
positive regulation of cell migration involved in sprouting angiogenesisbiological processAny process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
negative regulation of non-canonical NF-kappaB signal transductionbiological processAny process that stops, prevents or reduces the frequency, rate or extent of non-canonical NF-kappaB signaling cascade. [GOC:TermGenie]