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Acetylcholinesterase
An acetylcholinesterase that is encoded in the genome of rat. [PRO:DNx]
Synonyms
AChE;
EC 3.1.1.7
Research
Bioassay Publications (85)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (2.35) | 18.7374 |
| 1990's | 17 (20.00) | 18.2507 |
| 2000's | 26 (30.59) | 29.6817 |
| 2010's | 29 (34.12) | 24.3611 |
| 2020's | 11 (12.94) | 2.80 |
Compounds (46)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Feb-10, Volume: 48, Issue:3, 2005
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.Journal of the American Chemical Society, , Jan-15, Volume: 125, Issue:2, 2003
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Isolation, reactivity, pharmacological activities and total synthesis of hispanolone and structurally related diterpenes from Labiatae plants.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 30, Issue:21, 2020
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Fragment Linking Strategies for Structure-Based Drug Design.Journal of medicinal chemistry, , 10-22, Volume: 63, Issue:20, 2020
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 21, Issue:3, 2013
Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 21, Issue:5, 2013
Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:3, 2008
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , Sep-20, Volume: 14, Issue:18, 2004
Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-27, Volume: 46, Issue:7, 2003
Homodimeric tacrine congeners as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.Bioorganic & medicinal chemistry, , Volume: 7, Issue:2, 1999
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-16, Volume: 9, Issue:16, 1999
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.The Journal of biological chemistry, , Sep-27, Volume: 271, Issue:39, 1996
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.Journal of medicinal chemistry, , Jul-21, Volume: 38, Issue:15, 1995
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.Journal of medicinal chemistry, , Mar-04, Volume: 37, Issue:5, 1994
Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
(+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity.Journal of medicinal chemistry, , Volume: 31, Issue:7, 1988
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-27, Volume: 126, 2017
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-21, Volume: 130, 2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Exploration of multi-target potential of chromen-4-one based compounds in Alzheimer's disease: Design, synthesis and biological evaluations.Bioorganic & medicinal chemistry, , 12-15, Volume: 25, Issue:24, 2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Mar-01, Volume: 23, Issue:5, 2015
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry, , Feb-01, Volume: 21, Issue:3, 2013
Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H₃R and BACE 1 inhibitory activities.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 17, Issue:18, 2009
Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.European journal of medicinal chemistry, , Volume: 44, Issue:1, 2009
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.Bioorganic & medicinal chemistry, , Feb-15, Volume: 17, Issue:4, 2009
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:3, 2008
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.Journal of medicinal chemistry, , Jul-21, Volume: 38, Issue:15, 1995
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.Journal of medicinal chemistry, , Jul-19, Volume: 39, Issue:15, 1996
9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.Journal of medicinal chemistry, , Oct-08, Volume: 41, Issue:21, 1998
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.Journal of medicinal chemistry, , Jul-21, Volume: 38, Issue:15, 1995
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.Journal of medicinal chemistry, , Mar-04, Volume: 37, Issue:5, 1994
l-Hypaphorine and d-hypaphorine: Specific antiacetylcholinesterase activity in rat brain tissue.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 47, 2021
Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:2, 2009
Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors.Journal of natural products, , Volume: 67, Issue:11, 2004
Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.Journal of medicinal chemistry, , Jul-21, Volume: 38, Issue:15, 1995
Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Sep-01, Volume: 38, Issue:18, 1995
Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.Journal of medicinal chemistry, , Mar-04, Volume: 37, Issue:5, 1994
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Jan-19, Volume: 39, Issue:2, 1996
Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 60, 2022
Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , 12-15, Volume: 26, Issue:23-24, 2018
Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Chemical biology & drug design, , Volume: 86, Issue:5, 2015
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 24, Issue:19, 2014
Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 17, Issue:18, 2009
Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.European journal of medicinal chemistry, , Volume: 44, Issue:1, 2009
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety.Journal of medicinal chemistry, , Sep-16, Volume: 37, Issue:19, 1994
Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Jul-22, Volume: 37, Issue:15, 1994
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jul-28, Volume: 135, 2017
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.Journal of medicinal chemistry, , Sep-22, Volume: 59, Issue:18, 2016
Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.Chemical biology & drug design, , Volume: 86, Issue:5, 2015
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , 04-01, Volume: 61, 2022
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.European journal of medicinal chemistry, , May-26, Volume: 132, 2017
Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 63, 2013
Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.European journal of medicinal chemistry, , Volume: 62, 2013
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Homodimeric tacrine congeners as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-16, Volume: 9, Issue:16, 1999
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 13, Issue:20, 2003
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 13, Issue:20, 2003
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Oct-20, Volume: 13, Issue:20, 2003