3-benzyl-6-chloro-2-pyrone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 135053 |
| CHEMBL ID | 16433 |
| SCHEMBL ID | 6653211 |
| MeSH ID | M0114395 |
| Synonym |
|---|
| 2h-pyran-2-one, 6-chloro-3-(phenylmethyl)- |
| 85533-80-8 |
| 3-benzyl-6-chloro-2-pyrone |
| CHEMBL16433 , |
| 3-bcp |
| bdbm50025563 |
| 3-benzyl-6-chloro-pyran-2-one |
| 3-benzyl-6-chloropyran-2-one |
| DTXSID30234730 |
| SCHEMBL6653211 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chymotrypsin-C | Homo sapiens (human) | Ki | 76.0000 | 0.0010 | 0.9240 | 3.7000 | AID219114 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| proteolysis | Chymotrypsin-C | Homo sapiens (human) |
| intracellular calcium ion homeostasis | Chymotrypsin-C | Homo sapiens (human) |
| proteolysis | Chymotrypsin-C | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein binding | Chymotrypsin-C | Homo sapiens (human) |
| peptidase activity | Chymotrypsin-C | Homo sapiens (human) |
| serine-type endopeptidase activity | Chymotrypsin-C | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID219120 | Maximum rate of inactivation towards alpha-chymotrypsin calculated as the inactivation rate constant (Kinact) | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | Structure-activity study of 6-substituted 2-pyranones as inactivators of alpha-chymotrypsin. |
| AID26665 | Half-life period calculated by using rate of inactivation | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | Structure-activity study of 6-substituted 2-pyranones as inactivators of alpha-chymotrypsin. |
| AID219114 | In vitro binding affinity towards alpha-chymotrypsin from bovine pancreas. | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | Structure-activity study of 6-substituted 2-pyranones as inactivators of alpha-chymotrypsin. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.11) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||