Proteins > Peroxisome proliferator-activated receptor gamma
Page last updated: 2024-08-07 16:36:17

Peroxisome proliferator-activated receptor gamma

A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P37231]

Synonyms

PPAR-gamma;
Nuclear receptor subfamily 1 group C member 3

Research

Bioassay Publications (278)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (2.52)18.2507
2000's111 (39.93)29.6817
2010's128 (46.04)24.3611
2020's32 (11.51)2.80

Compounds (110)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
2,2-bis(4-glycidyloxyphenyl)propaneHomo sapiens (human)IC50100.000011
chelerythrineHomo sapiens (human)IC500.566011
ciglitazoneHomo sapiens (human)IC505.000011
ciglitazoneHomo sapiens (human)Ki3.090311
decanoic acidHomo sapiens (human)Ki22.000011
fenofibrateHomo sapiens (human)IC505.000011
glyburideHomo sapiens (human)Ki0.660011
pioglitazoneHomo sapiens (human)IC505.408188
pioglitazoneHomo sapiens (human)Ki0.576188
troglitazoneHomo sapiens (human)IC501.030066
troglitazoneHomo sapiens (human)Ki0.316855
pirinixic acidHomo sapiens (human)IC5053.700011
halofenateHomo sapiens (human)IC5040.000011
mifobateHomo sapiens (human)IC50140.000011
fenofibric acidHomo sapiens (human)IC50141.500066
telmisartanHomo sapiens (human)IC5012.200011
xanthomicrolHomo sapiens (human)IC505.400011
rosiglitazoneHomo sapiens (human)IC500.71094747
rosiglitazoneHomo sapiens (human)Ki0.09241717
gardenin bHomo sapiens (human)IC502.500011
mk 767Homo sapiens (human)IC500.463011
mk 767Homo sapiens (human)Ki0.330011
farglitazarHomo sapiens (human)IC500.121022
farglitazarHomo sapiens (human)Ki22,388.800955
muraglitazarHomo sapiens (human)IC500.186733
tesaglitazarHomo sapiens (human)IC500.350011
tesaglitazarHomo sapiens (human)Ki0.018011
2-(2-phenylethyl)chromoneHomo sapiens (human)Ki54.000011
gw 409544Homo sapiens (human)Ki0.001011
drf 2725Homo sapiens (human)IC500.092011
drf 2725Homo sapiens (human)Ki0.090011
gw9662Homo sapiens (human)IC503.300011
t 0070907Homo sapiens (human)IC501.000011
gsk 3787Homo sapiens (human)IC5010.000011
2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamideHomo sapiens (human)Ki0.002211
AngolensinHomo sapiens (human)IC5026.000011
hydroxypioglitazoneHomo sapiens (human)IC5013.000011
hydroxypioglitazoneHomo sapiens (human)Ki1.200011
clothiapineHomo sapiens (human)Ki0.075022
galanginHomo sapiens (human)Ki5.600011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)IC5027.000011
amorphastilbolHomo sapiens (human)IC500.850011
gw 1929Homo sapiens (human)Ki16,177.168567
alpha-glutamyltryptophanHomo sapiens (human)IC508.670022
gw 501516Homo sapiens (human)IC505.048745
tzd 18Homo sapiens (human)IC500.057033
tzd 18Homo sapiens (human)Ki0.060011
gw 9578Homo sapiens (human)IC500.550011
gw 7845Homo sapiens (human)IC5010.000011
gw 7845Homo sapiens (human)Ki0.003722
naveglitazarHomo sapiens (human)IC500.034022
ly 465608Homo sapiens (human)IC500.548011
ly 465608Homo sapiens (human)Ki0.550011
l 796449Homo sapiens (human)IC500.094033
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)IC500.173045
bm 131246Homo sapiens (human)IC500.014011
bm 131246Homo sapiens (human)Ki0.004311
tirotundinHomo sapiens (human)IC5027.000011
int 131Homo sapiens (human)IC500.017011
int 131Homo sapiens (human)Ki0.010022
aleglitazarHomo sapiens (human)IC500.019011
bavachininHomo sapiens (human)IC500.616711
bavachininHomo sapiens (human)Ki0.221411
msdc-0160Homo sapiens (human)IC5022.300011
gw9508Homo sapiens (human)Ki3.162311
lj 529Homo sapiens (human)Ki0.004611
bms 687453Homo sapiens (human)IC5015.000011
ys 121Homo sapiens (human)IC503.600011
10-nitro-oleic acidHomo sapiens (human)IC501.610011
gsk0660Homo sapiens (human)IC5010.000011
sr1664Homo sapiens (human)IC500.271333
ly 518674Homo sapiens (human)IC506.500622

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gw 2433Homo sapiens (human)EC502.500011
candesartan cilexetilHomo sapiens (human)EC504.200011
cannabinolHomo sapiens (human)EC5025.000011
ciglitazoneHomo sapiens (human)EC5018.904422
clofibrateHomo sapiens (human)EC50500.000022
clofibric acidHomo sapiens (human)EC50221.333333
decanoic acidHomo sapiens (human)EC5030.800022
fenofibrateHomo sapiens (human)EC50157.761766
gemfibrozilHomo sapiens (human)EC50121.333333
indomethacinHomo sapiens (human)EC5050.000011
lg 100268Homo sapiens (human)EC500.072533
pioglitazoneHomo sapiens (human)EC500.80273636
pioglitazoneHomo sapiens (human)Kd0.871011
troglitazoneHomo sapiens (human)EC501.10001919
pirinixic acidHomo sapiens (human)EC5029.29641011
pirinixic acidHomo sapiens (human)Kd1.318622
ici 204,219Homo sapiens (human)EC502.440011
3,3',5-triiodothyroacetic acidHomo sapiens (human)EC500.370011
3,3',5-triiodothyroacetic acidHomo sapiens (human)Kd0.200011
thyroxineHomo sapiens (human)EC5012.000011
thyroxineHomo sapiens (human)Kd0.400011
triiodothyronineHomo sapiens (human)EC505.800011
triiodothyronineHomo sapiens (human)Kd0.710011
methyleugenolHomo sapiens (human)EC5040.000011
cannabichromeneHomo sapiens (human)EC5025.000011
bezafibrateHomo sapiens (human)EC5067.42501212
pioglitazone hydrochlorideHomo sapiens (human)EC504.045022
fenofibric acidHomo sapiens (human)EC50171.888999
tetraiodothyroacetic acidHomo sapiens (human)EC500.100011
tetraiodothyroacetic acidHomo sapiens (human)Kd0.110011
telmisartanHomo sapiens (human)EC503.12771313
rosiglitazoneHomo sapiens (human)EC5070.3876147147
rosiglitazoneHomo sapiens (human)Kd1.210177
mk 767Homo sapiens (human)EC500.784188
mk 767Homo sapiens (human)Kd0.328022
jtt 501Homo sapiens (human)EC500.083022
anacardic acidHomo sapiens (human)EC5017.000011
farglitazarHomo sapiens (human)EC500.00201616
l 158809Homo sapiens (human)EC5020.000011
muraglitazarHomo sapiens (human)EC500.228499
tesaglitazarHomo sapiens (human)EC502.359489
eicosapentaenoic acidHomo sapiens (human)Kd2.000011
mycophenolic acidHomo sapiens (human)Kd110.000011
gw 409544Homo sapiens (human)EC500.000944
drf 2725Homo sapiens (human)EC500.580066
epipinoresinolHomo sapiens (human)EC5058.600011
cannabidiolHomo sapiens (human)EC5025.000011
gw9662Homo sapiens (human)EC500.002011
triiodothyronine, reverseHomo sapiens (human)EC503.800011
triiodothyronine, reverseHomo sapiens (human)Kd0.630011
sulindacHomo sapiens (human)EC5022.650011
sulindacHomo sapiens (human)Kd100.000011
2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamideHomo sapiens (human)EC502.940011
rivoglitazoneHomo sapiens (human)EC500.043011
gw 7647Homo sapiens (human)EC501.100011
gw 7647Homo sapiens (human)Kd0.180011
hydroxypioglitazoneHomo sapiens (human)EC501.360033
hydroxypioglitazoneHomo sapiens (human)Kd0.708011
alpha-linolenic acidHomo sapiens (human)Kd2.000011
clothiapineHomo sapiens (human)EC500.730011
psi-baptigeninHomo sapiens (human)EC5026.940033
9-hydroxy-10,12-octadecadienoic acidHomo sapiens (human)Kd2.000011
15-deoxy-delta(12,14)-prostaglandin j2Homo sapiens (human)Kd2.000011
cannabigerolHomo sapiens (human)EC5015.700011
sulindac sulfideHomo sapiens (human)EC500.800022
psammaplin aHomo sapiens (human)EC505.700011
pregna-4,17-diene-3,16-dioneHomo sapiens (human)EC50100.000011
amorphastilbolHomo sapiens (human)EC505.000011
gw 1929Homo sapiens (human)EC500.10251518
l-165041Homo sapiens (human)EC503.662022
gw 501516Homo sapiens (human)EC505.13491823
tzd 18Homo sapiens (human)EC500.012733
efatutazoneHomo sapiens (human)EC500.000522
lg 1506Homo sapiens (human)EC500.003022
nrx 194204Homo sapiens (human)EC500.031322
gft505Homo sapiens (human)EC502.678044
3-(2,4-dichlorobenzyl)-2-methyl-n-(pentylsulfonyl)-3 h-benzimidazole-5-carboxamideHomo sapiens (human)EC500.331522
gw 9578Homo sapiens (human)EC500.841088
gw 7845Homo sapiens (human)EC500.000755
naveglitazarHomo sapiens (human)EC500.380522
ly 465608Homo sapiens (human)EC500.880733
l 796449Homo sapiens (human)EC500.007122
gw0742Homo sapiens (human)EC505.765022
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)EC500.023011
ns-220Homo sapiens (human)EC507.816733
bm 131246Homo sapiens (human)EC500.005622
gw 590735Homo sapiens (human)EC507.780568
int 131Homo sapiens (human)EC500.176655
aleglitazarHomo sapiens (human)EC500.021011
msdc-0160Homo sapiens (human)EC500.657011
mbx-8025Homo sapiens (human)EC503.000022
cannabidiol hydroxyquinoneHomo sapiens (human)EC5010.500011
lt175Homo sapiens (human)EC500.4642810
lj 529Homo sapiens (human)EC504.640011
arhalofenateHomo sapiens (human)EC506.621733
odoratinHomo sapiens (human)EC503.100011
bms 687453Homo sapiens (human)EC503.653244
amorfrutin aHomo sapiens (human)EC500.458022
amorfrutin aHomo sapiens (human)Kd0.236011
amorfrutin bHomo sapiens (human)EC500.061522
amorfrutin bHomo sapiens (human)Kd0.019011
ys 121Homo sapiens (human)EC503.600022
[5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acidHomo sapiens (human)EC5050.000011
[5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acidHomo sapiens (human)Kd100.000011
sr1664Homo sapiens (human)EC504.288011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pioglitazoneHomo sapiens (human)Activity3.140022
troglitazoneHomo sapiens (human)Fold activation3.160011
rosiglitazoneHomo sapiens (human)Activity0.155022
hydroxypioglitazoneHomo sapiens (human)Activity2.610022
4-o-carboxymethylascochlorinHomo sapiens (human)MEC30.000011
gw 1929Homo sapiens (human)Log Ki8.840011
lt175Homo sapiens (human)Activity2.130022

Enables

This protein enables 28 target(s):

TargetCategoryDefinition
transcription cis-regulatory region bindingmolecular functionBinding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
transcription coregulator bindingmolecular functionBinding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. [GOC:krc]
DNA-binding transcription activator activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
nucleic acid bindingmolecular functionBinding to a nucleic acid. [GOC:jl]
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
double-stranded DNA bindingmolecular functionBinding to double-stranded DNA. [GOC:elh, GOC:vw]
DNA-binding transcription factor activitymolecular functionA transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
prostaglandin receptor activitymolecular functionCombining with a prostaglandin (PG) to initiate a change in cell activity. [ISBN:0198506732]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
peptide bindingmolecular functionBinding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
sequence-specific DNA bindingmolecular functionBinding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]
nuclear retinoid X receptor bindingmolecular functionBinding to a nuclear retinoid X receptor. [GOC:ai]
arachidonic acid bindingmolecular functionBinding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [GOC:ai]
DNA binding domain bindingmolecular functionBinding to a protein's DNA binding domain (DBD). [PMID:9682036]
LBD domain bindingmolecular functionBinding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036]
alpha-actinin bindingmolecular functionBinding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. [PMID:10984498, PMID:11699871, PMID:15014165]
R-SMAD bindingmolecular functionBinding to a receptor-regulated SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]
E-box bindingmolecular functionBinding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. [GOC:BHF, GOC:vk, PMID:11812799]
STAT family protein bindingmolecular functionBinding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses. [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978]
DNA-binding transcription factor bindingmolecular functionBinding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]
DNA-binding transcription repressor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
intracellular membrane-bounded organellecellular componentOrganized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
RNA polymerase II transcription regulator complexcellular componentA transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 61 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
placenta developmentbiological processThe process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
lipid metabolic processbiological processThe chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
activation of cysteine-type endopeptidase activity involved in apoptotic processbiological processAny process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
response to nutrientbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. [GOC:go_curators]
regulation of blood pressurebiological processAny process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
positive regulation of gene expressionbiological processAny process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of gene expressionbiological processAny process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
macrophage derived foam cell differentiationbiological processThe process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:dph, GOC:tb]
negative regulation of macrophage derived foam cell differentiationbiological processAny process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
negative regulation of cholesterol storagebiological processAny process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of lipid storagebiological processAny process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of sequestering of triglyceridebiological processAny process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of angiogenesisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. [GOC:go_curators]
monocyte differentiationbiological processThe process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah]
BMP signaling pathwaybiological processThe series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0878932437, PMID:17428827]
negative regulation of transforming growth factor beta receptor signaling pathwaybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]
epithelial cell differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751]
cellular response to insulin stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
response to lipidbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. [GOC:sl]
peroxisome proliferator activated receptor signaling pathwaybiological processThe series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes. [GOC:BHF, PMID:18221086]
glucose homeostasisbiological processAny process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
regulation of circadian rhythmbiological processAny process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb]
mRNA transcription by RNA polymerase IIbiological processThe cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. [GOC:jl, ISBN:0321000382]
lipoprotein transportbiological processThe directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl, ISBN:0198506732]
negative regulation of blood vessel endothelial cell migrationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
cell fate commitmentbiological processThe cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. [ISBN:0716731185]
positive regulation of fat cell differentiationbiological processAny process that activates or increases the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
retinoic acid receptor signaling pathwaybiological processThe series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh]
cell maturationbiological processThe cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. [GOC:go_curators]
rhythmic processbiological processAny process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid]
white fat cell differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. [PMID:12508945]
positive regulation of DNA-binding transcription factor activitybiological processAny process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]
lipid homeostasisbiological processAny process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl]
negative regulation of type II interferon-mediated signaling pathwaybiological processAny process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]
negative regulation of SMAD protein signal transductionbiological processAny process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. [GOC:BHF, GOC:dph, GOC:tb]
regulation of cholesterol transporter activitybiological processAny process that modulates the rate, frequency, or extent of cholesterol transporter activity. [GOC:BHF, GOC:dph, GOC:tb]
cellular response to low-density lipoprotein particle stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. [GOC:mah]
cellular response to hypoxiabiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
negative regulation of mitochondrial fissionbiological processAny process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:sl, GOC:tb]
regulation of cellular response to insulin stimulusbiological processAny process that modulates the frequency, rate or extent of cellular response to insulin stimulus. [GOC:TermGenie, GOC:yaf]
negative regulation of extracellular matrix assemblybiological processAny process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]
negative regulation of miRNA transcriptionbiological processAny process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
positive regulation of miRNA transcriptionbiological processAny process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
negative regulation of cellular response to transforming growth factor beta stimulusbiological processAny process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
positive regulation of adipose tissue developmentbiological processAny process that activates or increases the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
negative regulation of vascular associated smooth muscle cell proliferationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
positive regulation of vascular associated smooth muscle cell apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
negative regulation of vascular endothelial cell proliferationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
positive regulation of fatty acid metabolic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]
fatty acid metabolic processbiological processThe chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
negative regulation of inflammatory responsebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
hormone-mediated signaling pathwaybiological processThe series of molecular signals mediated by the detection of a hormone. [GOC:sm]