Page last updated: 2024-08-07 20:04:15

Sulfotransferase 1A1

A sulfotransferase 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50225]

Synonyms

ST1A1;
EC 2.8.2.1;
Aryl sulfotransferase 1;
HAST1/HAST2;
Phenol sulfotransferase 1;
Phenol-sulfating phenol sulfotransferase 1;
P-PST 1;
ST1A3;
Thermostable phenol sulfotransferase;
Ts-PST

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (10)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
amoxapineHomo sapiens (human)Ki80.000012
protriptylineHomo sapiens (human)Ki65.500014
ethinyl estradiolHomo sapiens (human)IC500.020011
ethinyl estradiolHomo sapiens (human)Ki0.014333
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleHomo sapiens (human)Ki0.005110

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ethinyl estradiolHomo sapiens (human)Kd0.252222

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ethinyl estradiolHomo sapiens (human)Km0.570022
2-naphtholHomo sapiens (human)Km0.170010
5-hydroxyindoleHomo sapiens (human)Km6.620010
6-hydroxybenzothiazoleHomo sapiens (human)Km2.080010
6-hydroxyindoleHomo sapiens (human)Km0.230010
4-hydroxytoremifeneHomo sapiens (human)Km2.600011
5-hydroxybenzimidazoleHomo sapiens (human)Km19.300010

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
aryl sulfotransferase activitymolecular functionCatalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
sulfotransferase activitymolecular functionCatalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators]
flavonol 3-sulfotransferase activitymolecular functionCatalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate. [EC:2.8.2.25, RHEA:13453]
steroid sulfotransferase activitymolecular functionCatalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. [MetaCyc:STEROID-SULFOTRANSFERASE-RXN, RHEA:68460]
3'-phosphoadenosine 5'-phosphosulfate bindingmolecular functionBinding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 8 target(s):

TargetCategoryDefinition
ethanol catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732]
catecholamine metabolic processbiological processThe chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:jl, ISBN:0198506732]
xenobiotic metabolic processbiological processThe chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
estrogen metabolic processbiological processThe chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
amine metabolic processbiological processThe chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732]
flavonoid metabolic processbiological processThe chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. [GOC:tair_curators, ISBN:0198547684]
3'-phosphoadenosine 5'-phosphosulfate metabolic processbiological processThe chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732]
sulfationbiological processThe addition of a sulfate group to a molecule. [Wikipedia:Sulfation]