Page last updated: 2024-08-07 20:04:15
Sulfotransferase 1A1
A sulfotransferase 1A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50225]
Synonyms
ST1A1;
EC 2.8.2.1;
Aryl sulfotransferase 1;
HAST1/HAST2;
Phenol sulfotransferase 1;
Phenol-sulfating phenol sulfotransferase 1;
P-PST 1;
ST1A3;
Thermostable phenol sulfotransferase;
Ts-PST
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ethinyl estradiol | Homo sapiens (human) | Kd | 0.2522 | 2 | 2 |
Drugs with Other Measurements
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| aryl sulfotransferase activity | molecular function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| sulfotransferase activity | molecular function | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators] |
| flavonol 3-sulfotransferase activity | molecular function | Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate. [EC:2.8.2.25, RHEA:13453] |
| steroid sulfotransferase activity | molecular function | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. [MetaCyc:STEROID-SULFOTRANSFERASE-RXN, RHEA:68460] |
| 3'-phosphoadenosine 5'-phosphosulfate binding | molecular function | Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|
| ethanol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. [GOC:ai, ISBN:0198506732] |
| catecholamine metabolic process | biological process | The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. [GOC:jl, ISBN:0198506732] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| estrogen metabolic process | biological process | The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732] |
| amine metabolic process | biological process | The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. [GOC:jl, ISBN:0198506732] |
| flavonoid metabolic process | biological process | The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. [GOC:tair_curators, ISBN:0198547684] |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process | biological process | The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [ISBN:0198506732] |
| sulfation | biological process | The addition of a sulfate group to a molecule. [Wikipedia:Sulfation] |