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Histamine H4 receptor
An H4 histamine receptor that is encoded in the genome of mouse. [OMA:Q91ZY2, PRO:DNx]
Synonyms
H4R;
HH4R
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
[no title available]Journal of medicinal chemistry, , 09-12, Volume: 62, Issue:17, 2019
Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H4 Receptor Agonists.Journal of medicinal chemistry, , Apr-14, Volume: 59, Issue:7, 2016
Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Histamine H4 receptor agonists.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
[no title available]Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
[no title available]Journal of medicinal chemistry, , 09-12, Volume: 62, Issue:17, 2019
[no title available]Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
[no title available]Journal of medicinal chemistry, , 09-12, Volume: 62, Issue:17, 2019
Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.European journal of medicinal chemistry, , Volume: 54, 2012
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.Journal of medicinal chemistry, , Oct-23, Volume: 51, Issue:20, 2008
A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.The Journal of pharmacology and experimental therapeutics, , Volume: 309, Issue:1, 2004
Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 21, Issue:21, 2011