Cathepsin B

A cathepsin B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07858]

Synonyms

EC 3.4.22.1;
APP secretase;
APPS;
Cathepsin B1

Research

Bioassay Publications (56)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (5.36)	18.2507
2000's	21 (37.50)	29.6817
2010's	26 (46.43)	24.3611
2020's	6 (10.71)	2.80

Compounds (45)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
diminazene	Homo sapiens (human)	IC50	30.0000	1	1
dibutyl phthalate	Homo sapiens (human)	IC50	420.0000	1	1
benzophenone	Homo sapiens (human)	IC50	288.8000	1	1
suramin	Homo sapiens (human)	IC50	30.0000	1	1
nitroxoline	Homo sapiens (human)	Ki	155.2333	6	6
allicin	Homo sapiens (human)	Ki	8.6000	1	1
aloxistatin	Homo sapiens (human)	IC50	14.3900	1	1
5,5'-methylenedisalicylic acid	Homo sapiens (human)	IC50	90.2000	1	1
leupeptin	Homo sapiens (human)	IC50	0.0282	2	2
leupeptin	Homo sapiens (human)	Ki	0.0063	3	3
carbobenzoxyvalylphenylalanine aldehyde	Homo sapiens (human)	Ki	0.0240	1	1
calpeptin	Homo sapiens (human)	IC50	100.0000	1	1
Pyrrolidine-1-carbonitrile	Homo sapiens (human)	IC50	20.0594	2	2
n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine	Homo sapiens (human)	Ki	0.0034	1	1
e 64	Homo sapiens (human)	IC50	0.0176	4	4
e 64	Homo sapiens (human)	Ki	16.0000	1	1
n-(3-ethoxycarbonyloxirane-2-carbonyl)-isoleucyl-proline	Homo sapiens (human)	IC50	0.0023	1	1
ak 295	Homo sapiens (human)	Ki	6.9000	1	1
bortezomib	Homo sapiens (human)	IC50	30.0000	1	1
acetylleucyl-leucyl-norleucinal	Homo sapiens (human)	Ki	0.1500	1	1
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	Homo sapiens (human)	Ki	0.1210	2	2
mg 262	Homo sapiens (human)	Ki	0.0061	1	1
telaprevir	Homo sapiens (human)	IC50	2.3033	3	3
benzyloxycarbonyl-phe-ala-fluormethylketone	Homo sapiens (human)	IC50	0.3000	1	1
guttiferone a	Homo sapiens (human)	IC50	2.1000	1	1
pepstatin	Homo sapiens (human)	IC50	4.2600	1	1
ca 074 methyl ester	Homo sapiens (human)	IC50	0.0800	1	1
relacatib	Homo sapiens (human)	IC50	0.0140	1	1
relacatib	Homo sapiens (human)	Ki	0.0051	2	7
ca 074	Homo sapiens (human)	IC50	1.5146	5	5
k11002	Homo sapiens (human)	Ki	11.0000	1	1
a-705253	Homo sapiens (human)	Ki	0.0280	1	1
l 006235	Homo sapiens (human)	IC50	1.9134	4	5
l 006235	Homo sapiens (human)	Ki	1.0000	1	1
l-873724	Homo sapiens (human)	IC50	2.8226	7	13
odanacatib	Homo sapiens (human)	IC50	1.3613	3	3
balicatib	Homo sapiens (human)	IC50	2.4958	5	6
balicatib	Homo sapiens (human)	Ki	3.3500	2	2
s-benzyl phenylmethanethiosulfinate	Homo sapiens (human)	Ki	7.8000	1	1
n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	Homo sapiens (human)	IC50	4.7500	2	2
calpain inhibitor iii	Homo sapiens (human)	IC50	0.5186	3	3
calpain inhibitor iii	Homo sapiens (human)	Ki	0.0215	2	2
epoxomicin	Homo sapiens (human)	IC50	120.0000	1	1
carfilzomib	Homo sapiens (human)	IC50	11.0000	1	1
PF-00835231	Homo sapiens (human)	IC50	0.8102	3	5
mk-7009	Homo sapiens (human)	IC50	10,000.0000	1	1
gallinamide a	Homo sapiens (human)	IC50	1.9691	3	3
gallinamide a	Homo sapiens (human)	Ki	0.1170	1	1
bi 201335	Homo sapiens (human)	IC50	26.0000	1	1
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile	Homo sapiens (human)	IC50	10.7152	1	1
grassystatin a	Homo sapiens (human)	IC50	10.0000	1	1
N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide	Homo sapiens (human)	IC50	0.0041	1	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
l 006235	Homo sapiens (human)	EC50	0.7900	1	1
balicatib	Homo sapiens (human)	EC50	2.9000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
cysteine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
collagen binding	molecular function	Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
cysteine-type peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
proteoglycan binding	molecular function	Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [ISBN:0198506732]

Located In

This protein is located in 11 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
endolysosome lumen	cellular component	The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. [GOC:pde]
melanosome	cellular component	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
collagen-containing extracellular matrix	cellular component	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
ficolin-1-rich granule lumen	cellular component	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
peptidase inhibitor complex	cellular component	A protein complex which is capable of peptidase inhibitor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
thyroid hormone generation	biological process	The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. [GOC:jl, ISBN:0716720094]
collagen catabolic process	biological process	The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]
epithelial cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751]
regulation of apoptotic process	biological process	Any process that modulates the occurrence or rate of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
decidualization	biological process	The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. [ISBN:0721662544, PMID:11133685]
symbiont entry into host cell	biological process	The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. [GOC:jl]
proteolysis involved in protein catabolic process	biological process	The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. [GOC:ai, GOC:dph, GOC:tb]
cellular response to thyroid hormone stimulus	biological process	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. [GOC:sjw, PMID:9916872]

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