A receptor-type tyrosine-protein phosphatase F that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10586]
EC 3.1.3.48;
Leukocyte common antigen related;
LAR
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 6 (40.00) | 29.6817 |
2010's | 9 (60.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
4-hydroxyphenylglyoxylic acid | Homo sapiens (human) | IC50 | 2,300.0000 | 1 | 1 |
5-iodo-2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 420.0000 | 2 | 2 |
oleanolic acid | Homo sapiens (human) | IC50 | 33.3733 | 5 | 6 |
vanadates | Homo sapiens (human) | IC50 | 22.5633 | 1 | 3 |
ursolic acid | Homo sapiens (human) | IC50 | 21.9000 | 2 | 2 |
maslinic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
cryptotanshinone | Homo sapiens (human) | IC50 | 36.9000 | 1 | 1 |
2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 2,000.0000 | 2 | 2 |
moronic acid | Homo sapiens (human) | IC50 | 45.6000 | 1 | 1 |
morolic acid | Homo sapiens (human) | IC50 | 35.9000 | 1 | 1 |
cefsulodin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
illudalic acid | Homo sapiens (human) | IC50 | 1.7000 | 2 | 2 |
illudalic acid | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
2-amino-6-chloropurine | Homo sapiens (human) | IC50 | 75.9400 | 1 | 5 |
corosolic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
This protein enables 6 target(s):
Target | Category | Definition |
---|---|---|
protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
transmembrane receptor protein tyrosine phosphatase activity | molecular function | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
heparin binding | molecular function | Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732] |
chondroitin sulfate proteoglycan binding | molecular function | Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit. [GOC:kmv, ISBN:0198506732] |
protein-containing complex binding | molecular function | Binding to a macromolecular complex. [GOC:jl] |
cell adhesion molecule binding | molecular function | Binding to a cell adhesion molecule. [GOC:ai] |
This protein is located in 4 target(s):
Target | Category | Definition |
---|---|---|
plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
neuron projection | cellular component | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] |
neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is involved in 8 target(s):
Target | Category | Definition |
---|---|---|
cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
cell surface receptor protein tyrosine phosphatase signaling pathway | biological process | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling] |
cell migration | biological process | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] |
neuron projection regeneration | biological process | The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. [GOC:dgh, GOC:dph, GOC:tb] |
peptidyl-tyrosine dephosphorylation | biological process | The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf] |
regulation of axon regeneration | biological process | Any process that modulates the frequency, rate or extent of axon regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] |
synaptic membrane adhesion | biological process | The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. [GOC:dos] |
negative regulation of receptor binding | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie] |