Page last updated: 2024-08-07 15:52:39

Receptor-type tyrosine-protein phosphatase F

A receptor-type tyrosine-protein phosphatase F that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10586]

Synonyms

EC 3.1.3.48;
Leukocyte common antigen related;
LAR

Research

Bioassay Publications (15)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (40.00)29.6817
2010's9 (60.00)24.3611
2020's0 (0.00)2.80

Compounds (15)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-hydroxyphenylglyoxylic acidHomo sapiens (human)IC502,300.000011
5-iodo-2-(oxaloamino)benzoic acidHomo sapiens (human)Ki420.000022
oleanolic acidHomo sapiens (human)IC5033.373356
vanadatesHomo sapiens (human)IC5022.563313
ursolic acidHomo sapiens (human)IC5021.900022
maslinic acidHomo sapiens (human)IC5040.000011
cryptotanshinoneHomo sapiens (human)IC5036.900011
2-(oxaloamino)benzoic acidHomo sapiens (human)Ki2,000.000022
moronic acidHomo sapiens (human)IC5045.600011
morolic acidHomo sapiens (human)IC5035.900011
cefsulodinHomo sapiens (human)IC50200.000011
illudalic acidHomo sapiens (human)IC501.700022
illudalic acidHomo sapiens (human)Ki130.000011
2-amino-6-chloropurineHomo sapiens (human)IC5075.940015
corosolic acidHomo sapiens (human)IC5040.000011
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acidHomo sapiens (human)IC5050.000011

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
protein tyrosine phosphatase activitymolecular functionCatalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
transmembrane receptor protein tyrosine phosphatase activitymolecular functionCombining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
heparin bindingmolecular functionBinding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]
chondroitin sulfate proteoglycan bindingmolecular functionBinding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit. [GOC:kmv, ISBN:0198506732]
protein-containing complex bindingmolecular functionBinding to a macromolecular complex. [GOC:jl]
cell adhesion molecule bindingmolecular functionBinding to a cell adhesion molecule. [GOC:ai]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
neuronal cell bodycellular componentThe portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 8 target(s):

TargetCategoryDefinition
cell adhesionbiological processThe attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
cell surface receptor protein tyrosine phosphatase signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
cell migrationbiological processThe controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
neuron projection regenerationbiological processThe regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. [GOC:dgh, GOC:dph, GOC:tb]
peptidyl-tyrosine dephosphorylationbiological processThe removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]
regulation of axon regenerationbiological processAny process that modulates the frequency, rate or extent of axon regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
synaptic membrane adhesionbiological processThe attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. [GOC:dos]
negative regulation of receptor bindingbiological processAny process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie]