cefmenoxime and Necrosis

cefmenoxime has been researched along with Necrosis* in 1 studies

Other Studies

1 other study(ies) available for cefmenoxime and Necrosis

Article	Year
Cefmenoxime in corneal organ culture. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1994, Volume: 208, Issue:5 Before introducing new antibiotics for corneal organ culture solutions, information about the endothelial cell toxicity is necessary. Therefore, we preserved 132 pig corneas in minimum essential medium with 2% fetal calf serum and 5% dextran T 500 and added 50, 100, 250 and 500 micrograms/cm3 cefmenoxime. Slight endothelial cell damage occurred at a concentration of 100 micrograms/cm3. Damage to endothelial cells was demonstrated by the inhibited uptake of fluorescein diacetate and by other staining procedures. 30% of the substance remained stable during a 10-day culture period as demonstrated by an HPLC method. Topics: Animals; Biological Transport; Cefmenoxime; Cell Survival; Cornea; Culture Media; Dose-Response Relationship, Drug; Endothelium, Corneal; Fluoresceins; Necrosis; Organ Culture Techniques; Organ Preservation; Swine	1994

Article

Year

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1994, Volume: 208, Issue:5

Before introducing new antibiotics for corneal organ culture solutions, information about the endothelial cell toxicity is necessary. Therefore, we preserved 132 pig corneas in minimum essential medium with 2% fetal calf serum and 5% dextran T 500 and added 50, 100, 250 and 500 micrograms/cm3 cefmenoxime. Slight endothelial cell damage occurred at a concentration of 100 micrograms/cm3. Damage to endothelial cells was demonstrated by the inhibited uptake of fluorescein diacetate and by other staining procedures. 30% of the substance remained stable during a 10-day culture period as demonstrated by an HPLC method.

Topics: Animals; Biological Transport; Cefmenoxime; Cell Survival; Cornea; Culture Media; Dose-Response Relationship, Drug; Endothelium, Corneal; Fluoresceins; Necrosis; Organ Culture Techniques; Organ Preservation; Swine

1994