Proteins > Monocarboxylate transporter 4
Page last updated: 2024-08-07 23:01:51
Monocarboxylate transporter 4
A monocarboxylate transporter 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15427]
Synonyms
MCT 4;
Solute carrier family 16 member 3
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
Compounds (18)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| alpha-ketoisovalerate | Homo sapiens (human) | Km | 113,000.0000 | 1 | 1 |
| alpha-ketobutyric acid | Homo sapiens (human) | Km | 57,000.0000 | 1 | 1 |
| 2-keto-4-methylvalerate | Homo sapiens (human) | Km | 95,000.0000 | 1 | 1 |
| acetoacetic acid | Homo sapiens (human) | Km | 216,000.0000 | 1 | 1 |
| pyruvic acid | Homo sapiens (human) | Km | 153,000.0000 | 1 | 1 |
| 3-chloropropionic acid | Homo sapiens (human) | Km | 51,000.0000 | 1 | 1 |
| 2-hydroxybutyric acid | Homo sapiens (human) | Km | 56,000.0000 | 1 | 1 |
| d-lactic acid | Homo sapiens (human) | Km | 519,000.0000 | 1 | 1 |
| 3-hydroxybutyric acid | Homo sapiens (human) | Km | 130,000.0000 | 1 | 1 |
| (S)-3-hydroxybutyric acid | Homo sapiens (human) | Km | 824,000.0000 | 1 | 1 |
| sodium lactate | Homo sapiens (human) | Km | 28,000.0000 | 1 | 1 |
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| monocarboxylic acid transmembrane transporter activity | molecular function | Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. [GOC:ai] |
| lactate:proton symporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in). [TC:2.A.14.1.1] |
| pyruvate transmembrane transporter activity | molecular function | Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. [GOC:ai] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| lateral plasma membrane | cellular component | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| lactate transmembrane transport | biological process | The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. [GOC:mcc, ISBN:0198506732] |
| pyruvate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate. [GOC:go_curators] |
| pyruvate transmembrane transport | biological process | The directed movement of pyruvate across a membrane. [GOC:TermGenie] |
| monocarboxylic acid transport | biological process | The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |