A kinesin-1 heavy chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P33176]
Conventional kinesin heavy chain;
Ubiquitous kinesin heavy chain;
UKHC
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| whi p180 | Homo sapiens (human) | IC50 | 0.3800 | 1 | 1 |
| staurosporine | Homo sapiens (human) | IC50 | 0.0015 | 1 | 1 |
| zd 6474 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| lenvatinib | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| cabozantinib | Homo sapiens (human) | GI50 | 0.0870 | 1 | 1 |
| cabozantinib | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| microtubule motor activity | molecular function | A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. [PMID:19686686, PMID:32684327, PMID:32842864] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| microtubule binding | molecular function | Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein-containing complex binding | molecular function | Binding to a macromolecular complex. [GOC:jl] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
| ATP hydrolysis activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065] |
| plus-end-directed microtubule motor activity | molecular function | A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. [GOC:vw, PMID:32842864] |
This protein is located in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| vesicle | cellular component | Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles] |
| dendrite cytoplasm | cellular component | All of the contents of a dendrite, excluding the surrounding plasma membrane. [GOC:mah] |
| centriolar satellite | cellular component | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. [GOC:BHF, PMID:10579718, PMID:12403812] |
| ciliary rootlet | cellular component | A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. [GOC:cilia, PMID:12427867] |
| phagocytic vesicle | cellular component | A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. [GOC:go_curators, ISBN:0198506732] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| cytolytic granule membrane | cellular component | The lipid bilayer surrounding the cytolytic granule. [PMID:17272266, PMID:21247065] |
| axon cytoplasm | cellular component | Any cytoplasm that is part of a axon. [GO_REF:0000064, GOC:TermGenie, PMID:18667152] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| microtubule | cellular component | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| kinesin complex | cellular component | Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] |
This protein is involved in 21 target(s):
| Target | Category | Definition |
|---|---|---|
| microtubule-based movement | biological process | A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. [GOC:cjm, ISBN:0815316194] |
| cytoplasm organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [GOC:curators, GOC:dph, GOC:jl, GOC:mah] |
| positive regulation of synaptic transmission, GABAergic | biological process | Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah] |
| lysosome localization | biological process | Any process in which a lysosome is transported to, and/or maintained in, a specific location. [GOC:mah] |
| stress granule disassembly | biological process | The disaggregation of a stress granule into its constituent protein and RNA parts. [GOC:BHF, PMID:19825938] |
| natural killer cell mediated cytotoxicity | biological process | The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, GOC:pr] |
| regulation of membrane potential | biological process | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] |
| positive regulation of potassium ion transport | biological process | Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl] |
| vesicle transport along microtubule | biological process | The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. [GOC:ecd, GOC:rl] |
| mitochondrion transport along microtubule | biological process | The directed movement of a mitochondrion along a microtubule, mediated by motor proteins. [GOC:ecd] |
| centrosome localization | biological process | Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. [GOC:ai] |
| cellular response to type II interferon | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. [GOC:mah] |
| plus-end-directed vesicle transport along microtubule | biological process | The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. [GOC:BHF, GOC:mah] |
| anterograde axonal protein transport | biological process | The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. [GOC:dos] |
| mitocytosis | biological process | A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells. [PMID:34108688] |
| positive regulation of protein localization to plasma membrane | biological process | Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] |
| anterograde neuronal dense core vesicle transport | biological process | The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. [GOC:kmv, PMID:23358451] |
| retrograde neuronal dense core vesicle transport | biological process | The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body. [GOC:kmv, PMID:23358451, PMID:24762653] |
| axon guidance | biological process | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437] |
| synaptic vesicle transport | biological process | The directed movement of synaptic vesicles. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr] |
| anterograde dendritic transport of neurotransmitter receptor complex | biological process | The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse. [GOC:dos] |