Page last updated: 2024-10-26

diclofenac and Necrosis

diclofenac has been researched along with Necrosis in 32 studies

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" This report describes a term newborn with severe persistent pulmonary hypertension due to premature closure of the ductus arteriosus following a 5 day maternal treatment with diclofenac two weeks before delivery."7.70Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report. ( Klinge, J; Krüger, C; Scharf, J; Singer, H; Zenker, M, 1998)
"Intramuscular administration of diclofenac may be associated with severe tissue necrosis or necrotizing fasciitis."7.69Tissue necrosis and necrotizing fasciitis after intramuscular administration of diclofenac. ( O'Connor, N; Pillans, PI, 1995)
" The symptoms seemed to have been initiated by minor skin trauma; intramuscular injections of diclofenac (Voltaren) and metoclopramide (Primperan) after which the patient developed extensive muscle necrosis."7.69Streptococcal myositis and tissue necrosis with intramuscular administration of diclofenac (Voltaren). ( Kvam, AM; Rygnestad, T, 1995)
"Tissue necrosis is a rare but serious complication of intramuscular injections."5.36Skin necrosis after self-administered intramuscular diclofenac. ( Arad, E; Uri, O, 2010)
"Clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by multiple adverse effects, including renal toxicity leading to acute kidney injury."3.78Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury. ( Bao, H; Dworkin, LD; Ge, Y; Gong, R; Liu, Z; Zhuang, S, 2012)
" The authors report a case of myocardial necrosis and anaphylactic shock due to treatment with diclofenac and misoprostol."3.71[Anaphylactic shock and myocytic necrosis after treatment with Artotec]. ( Bellorini, M; Funck, F; Guillard, N; Jourdain, P; Loiret, J; Meuleman, C; Sadeg, N; Thebault, B, 2002)
" This report describes a term newborn with severe persistent pulmonary hypertension due to premature closure of the ductus arteriosus following a 5 day maternal treatment with diclofenac two weeks before delivery."3.70Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report. ( Klinge, J; Krüger, C; Scharf, J; Singer, H; Zenker, M, 1998)
" The symptoms seemed to have been initiated by minor skin trauma; intramuscular injections of diclofenac (Voltaren) and metoclopramide (Primperan) after which the patient developed extensive muscle necrosis."3.69Streptococcal myositis and tissue necrosis with intramuscular administration of diclofenac (Voltaren). ( Kvam, AM; Rygnestad, T, 1995)
"A 35-year-old man presented with a painful skin necrosis after a deep ventrogluteal injection of diclofenac and dexamethasone for treatment of severe back pain."3.69Embolia cutis medicamentosa. ( Köhler, LD; Schwedler, S; Worret, WI, 1997)
"This study addresses the question of whether the cyclooxygenase inhibitors indomethacin and diclofenac and the glucocorticosteroid dexamethasone ameliorate neuronal necrosis following cerebral ischemia."3.67Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. ( Koide, T; Siesjö, BK; Wieloch, TW, 1986)
" First, we established the dosing condition for liver injury in normal mice."1.38Involvement of immune-related factors in diclofenac-induced acute liver injury in mice. ( Fukami, T; Higuchi, S; Nakajima, M; Tsuneyama, K; Yano, A; Yokoi, T, 2012)
"Tissue necrosis is a rare but serious complication of intramuscular injections."1.36Skin necrosis after self-administered intramuscular diclofenac. ( Arad, E; Uri, O, 2010)
"Nicolau syndrome is rare cutaneous adverse reaction following injection of various drugs."1.36Nicolau syndrome and perforator vessels: a new viewpoint for an old problem. ( Canter, HI; Okan, G, 2010)
"diclofenac injection has rarely been reported in the published work."1.35Nicolau syndrome aggravated by cold application after i.m. diclofenac. ( Ada, S; Cağlar, B; Güleç, AT; Senel, E, 2008)
"Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is widely used for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute muscle pain conditions."1.31Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. ( Gross, SM; Hickey, EJ; Raje, RR; Ray, SD; Reid, VE, 2001)
"A case of necrotizing fasciitis in a healthy woman taking a nonsteroidal antiinflammatory drug in the puerperium is presented."1.29Necrotizing fasciitis in the puerperium. ( North, RA; Rowan, JA, 1995)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.13)18.7374
1990's9 (28.13)18.2507
2000's14 (43.75)29.6817
2010's7 (21.88)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Almehizia, AA1
Khattab, AEA1
Darwish, AM1
Al-Omar, MA1
Naglah, AM1
Bhat, MA1
Kalmouch, A1
Erdem, N1
Çizmecioğlu, A1
Aydoğdu, İ3
Julião, M1
Cunha, I1
Costa, A1
Hamilton, B1
Fowler, P1
Galloway, H1
Popovic, N1
Uri, O1
Arad, E1
Okan, G1
Canter, HI1
Marangi, GF1
Gigliofiorito, P1
Toto, V1
Langella, M1
Pallara, T1
Persichetti, P1
Bao, H1
Ge, Y1
Zhuang, S1
Dworkin, LD1
Liu, Z1
Gong, R1
Yano, A1
Higuchi, S1
Tsuneyama, K1
Fukami, T1
Nakajima, M1
Yokoi, T1
Meuleman, C1
Jourdain, P1
Bellorini, M1
Guillard, N1
Loiret, J1
Thebault, B1
Sadeg, N1
Funck, F1
Palop Larrea, V1
Belenguer Varea, A1
Cuesta Romero, C1
Mallent Añón, J1
Mayrink, M1
Mendonça, AC1
da Costa, PR1
Miyabara, EH1
Tostes, RC1
Selistre de Araújo, HS1
Aoki, MS1
Salvini, TF1
Moriscot, AS1
Bajaj, DR1
Qureshi, AA1
Kekilli, E1
Yagmur, C1
Kaya, E2
Kuku, I2
Ertem, K1
Erkurt, MA1
Ozhan, O1
Yitmen, E1
Aydin, NE1
Lie, C1
Leung, F1
Chow, SP1
Mutalik, S1
Belgaumkar, V1
Pandhi, D1
Mehta, S1
Agrawal, S1
Singal, A1
Sarifakioglu, E1
Senel, E1
Ada, S1
Güleç, AT1
Cağlar, B1
Pillans, PI1
O'Connor, N1
Rowan, JA1
North, RA1
Bulbena, O1
Escolar, G1
Navarro, C1
Bravo, L1
Pfeiffer, CJ1
Rygnestad, T1
Kvam, AM1
Köhler, LD1
Schwedler, S1
Worret, WI1
Seed, MP1
Freemantle, CN1
Alam, CA1
Colville-Nash, PR1
Brown, JR1
Papworth, JL1
Somerville, KW1
Willoughby, DA1
Zenker, M1
Klinge, J1
Krüger, C1
Singer, H1
Scharf, J1
Hickey, EJ1
Raje, RR1
Reid, VE1
Gross, SM1
Ray, SD1
Stricker, BH1
van Kasteren, BJ1
Helfgott, SM1
Sandberg-Cook, J1
Zakim, D1
Nestler, J1
Koide, T1
Wieloch, TW1
Siesjö, BK1

Reviews

1 review available for diclofenac and Necrosis

ArticleYear
Soft-tissue sarcoma arising from a tissue necrosis caused by an intramuscular injection of diclofenac.
    Plastic and reconstructive surgery, 2003, Volume: 112, Issue:7

    Topics: Buttocks; Diclofenac; Female; Humans; Injections, Intramuscular; Middle Aged; Necrosis; Sarcoma; Ski

2003

Other Studies

31 other studies available for diclofenac and Necrosis

ArticleYear
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Dioxide; Colitis; Colon; Diclofenac; Disease

2023
From Bone Marrow Necrosis to Gaucher Disease; A Long Way to Run.
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2015, Volume: 32, Issue:4

    Topics: Bone Marrow; Bone Marrow Examination; Diagnostic Errors; Diclofenac; Gaucher Disease; Glucosylcerami

2015
Skin Necrosis after Subcutaneous Diclofenac Administration: A Case Report.
    Journal of palliative medicine, 2016, Volume: 19, Issue:6

    Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Injections,

2016
Nicolau syndrome in an athlete following intra-muscular diclofenac injection.
    Acta orthopaedica Belgica, 2008, Volume: 74, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diclofenac; Drug Eruptions; Heparin,

2008
Skin necrosis after self-administered intramuscular diclofenac.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2010, Volume: 63, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Cellulitis; Diclofenac; Humans; Injections, Intr

2010
Nicolau syndrome and perforator vessels: a new viewpoint for an old problem.
    Cutaneous and ocular toxicology, 2010, Volume: 29, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Debridement; Diclofenac; Drug

2010
Three cases of embolia cutis medicamentosa (Nicolau's syndrome).
    The Journal of dermatology, 2010, Volume: 37, Issue:5

    Topics: Aged; Diclofenac; Fat Necrosis; Female; Humans; Injections, Intramuscular; Ketorolac; Middle Aged; N

2010
Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury.
    Kidney international, 2012, Volume: 81, Issue:7

    Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopt

2012
Involvement of immune-related factors in diclofenac-induced acute liver injury in mice.
    Toxicology, 2012, Mar-11, Volume: 293, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury;

2012
[Anaphylactic shock and myocytic necrosis after treatment with Artotec].
    Archives des maladies du coeur et des vaisseaux, 2002, Volume: 95, Issue:12

    Topics: Aged; Anaphylaxis; Anti-Ulcer Agents; Diclofenac; Humans; Male; Misoprostol; Myocardium; Necrosis

2002
[Intramuscular aceclofenac and necrosis at the point of injection with fatal outcome].
    Atencion primaria, 2003, Jun-30, Volume: 32, Issue:2

    Topics: Abscess; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drainage; Fat

2003
Cyclosporin A attenuates skeletal muscle damage induced by crotoxin in rats.
    Toxicon : official journal of the International Society on Toxinology, 2004, Volume: 43, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcineurin Inhibitors; Crotoxin; Cyclosporine; Di

2004
Embolia cutis medicamentosa.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2005, Volume: 15, Issue:3

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Diclofenac; Drug Hypersensitivity; Female; Fo

2005
Decreased Tc-99m MDP uptake in myelonecrosis.
    Clinical nuclear medicine, 2006, Volume: 31, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Diseases; Diclofenac; Humans; Male; Necr

2006
Reversible bone marrow necrosis in a patient due to overdosage of diclofenac sodium.
    American journal of hematology, 2006, Volume: 81, Issue:4

    Topics: Adult; Bone Marrow; Bone Marrow Diseases; Cyclooxygenase Inhibitors; Diclofenac; Humans; Male; Necro

2006
Nicolau syndrome following intramuscular diclofenac administration: a case report.
    Journal of orthopaedic surgery (Hong Kong), 2006, Volume: 14, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Eruptions; Fat Necrosis; Humans; Injection

2006
Nicolau syndrome: a report of 2 cases.
    Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Injections, Intramuscular; Male;

2006
Erythema nodosum leprosum necroticans in a child--an unusual manifestation.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2005, Volume: 73, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Diclofenac; Drug Therapy, Combination; Erythema Nodo

2005
Nicolau syndrome after diclofenac injection.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2007, Volume: 21, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Buttocks; Diclofenac; Erythema; Female; Humans;

2007
Nicolau syndrome aggravated by cold application after i.m. diclofenac.
    The Journal of dermatology, 2008, Volume: 35, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Buttocks; Cold Temperature; Diclofenac; Drug Eruptions; Fem

2008
Tissue necrosis and necrotizing fasciitis after intramuscular administration of diclofenac.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:3

    Topics: Adult; Diclofenac; Fasciitis; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Necrosis

1995
Necrotizing fasciitis in the puerperium.
    American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fasciitis; Female; Humans; Necrosis; Pue

1995
Gastroprotective effect of zinc acexamate against damage induced by nonsteroidal antiinflammatory drugs. A morphological study.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:4

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen

1993
Streptococcal myositis and tissue necrosis with intramuscular administration of diclofenac (Voltaren).
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:8

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Injections, Intramuscular; Male;

1995
Embolia cutis medicamentosa.
    International journal of dermatology, 1997, Volume: 36, Issue:3

    Topics: Adult; Dexamethasone; Diclofenac; Drug Eruptions; Embolism; Humans; Injections, Intramuscular; Male;

1997
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm

1997
Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report.
    Journal of perinatal medicine, 1998, Volume: 26, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ductus Arteriosus; Female; Humans; Hypertension

1998
Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death.
    Free radical biology & medicine, 2001, Jul-15, Volume: 31, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Diclofenac; DNA Fragmentation; Endodeox

2001
Diclofenac-induced isolated myonecrosis and the Nicolau syndrome.
    Annals of internal medicine, 1992, Dec-15, Volume: 117, Issue:12

    Topics: Adult; Diclofenac; Humans; Injections, Intramuscular; Ischemia; Male; Muscular Diseases; Necrosis; S

1992
Diclofenac-associated hepatotoxicity.
    JAMA, 1990, Nov-28, Volume: 264, Issue:20

    Topics: Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Fibromyalgi

1990
Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:4

    Topics: Animals; Blood Glucose; Brain Chemistry; Brain Ischemia; Cyclooxygenase Inhibitors; Dexamethasone; D

1986