diclofenac has been researched along with Necrosis in 32 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This report describes a term newborn with severe persistent pulmonary hypertension due to premature closure of the ductus arteriosus following a 5 day maternal treatment with diclofenac two weeks before delivery." | 7.70 | Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report. ( Klinge, J; Krüger, C; Scharf, J; Singer, H; Zenker, M, 1998) |
| "Intramuscular administration of diclofenac may be associated with severe tissue necrosis or necrotizing fasciitis." | 7.69 | Tissue necrosis and necrotizing fasciitis after intramuscular administration of diclofenac. ( O'Connor, N; Pillans, PI, 1995) |
| " The symptoms seemed to have been initiated by minor skin trauma; intramuscular injections of diclofenac (Voltaren) and metoclopramide (Primperan) after which the patient developed extensive muscle necrosis." | 7.69 | Streptococcal myositis and tissue necrosis with intramuscular administration of diclofenac (Voltaren). ( Kvam, AM; Rygnestad, T, 1995) |
| "Tissue necrosis is a rare but serious complication of intramuscular injections." | 5.36 | Skin necrosis after self-administered intramuscular diclofenac. ( Arad, E; Uri, O, 2010) |
| "Clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by multiple adverse effects, including renal toxicity leading to acute kidney injury." | 3.78 | Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury. ( Bao, H; Dworkin, LD; Ge, Y; Gong, R; Liu, Z; Zhuang, S, 2012) |
| " The authors report a case of myocardial necrosis and anaphylactic shock due to treatment with diclofenac and misoprostol." | 3.71 | [Anaphylactic shock and myocytic necrosis after treatment with Artotec]. ( Bellorini, M; Funck, F; Guillard, N; Jourdain, P; Loiret, J; Meuleman, C; Sadeg, N; Thebault, B, 2002) |
| " This report describes a term newborn with severe persistent pulmonary hypertension due to premature closure of the ductus arteriosus following a 5 day maternal treatment with diclofenac two weeks before delivery." | 3.70 | Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report. ( Klinge, J; Krüger, C; Scharf, J; Singer, H; Zenker, M, 1998) |
| " The symptoms seemed to have been initiated by minor skin trauma; intramuscular injections of diclofenac (Voltaren) and metoclopramide (Primperan) after which the patient developed extensive muscle necrosis." | 3.69 | Streptococcal myositis and tissue necrosis with intramuscular administration of diclofenac (Voltaren). ( Kvam, AM; Rygnestad, T, 1995) |
| "A 35-year-old man presented with a painful skin necrosis after a deep ventrogluteal injection of diclofenac and dexamethasone for treatment of severe back pain." | 3.69 | Embolia cutis medicamentosa. ( Köhler, LD; Schwedler, S; Worret, WI, 1997) |
| "This study addresses the question of whether the cyclooxygenase inhibitors indomethacin and diclofenac and the glucocorticosteroid dexamethasone ameliorate neuronal necrosis following cerebral ischemia." | 3.67 | Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. ( Koide, T; Siesjö, BK; Wieloch, TW, 1986) |
| " First, we established the dosing condition for liver injury in normal mice." | 1.38 | Involvement of immune-related factors in diclofenac-induced acute liver injury in mice. ( Fukami, T; Higuchi, S; Nakajima, M; Tsuneyama, K; Yano, A; Yokoi, T, 2012) |
| "Tissue necrosis is a rare but serious complication of intramuscular injections." | 1.36 | Skin necrosis after self-administered intramuscular diclofenac. ( Arad, E; Uri, O, 2010) |
| "Nicolau syndrome is rare cutaneous adverse reaction following injection of various drugs." | 1.36 | Nicolau syndrome and perforator vessels: a new viewpoint for an old problem. ( Canter, HI; Okan, G, 2010) |
| "diclofenac injection has rarely been reported in the published work." | 1.35 | Nicolau syndrome aggravated by cold application after i.m. diclofenac. ( Ada, S; Cağlar, B; Güleç, AT; Senel, E, 2008) |
| "Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is widely used for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute muscle pain conditions." | 1.31 | Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. ( Gross, SM; Hickey, EJ; Raje, RR; Ray, SD; Reid, VE, 2001) |
| "A case of necrotizing fasciitis in a healthy woman taking a nonsteroidal antiinflammatory drug in the puerperium is presented." | 1.29 | Necrotizing fasciitis in the puerperium. ( North, RA; Rowan, JA, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Almehizia, AA | 1 |
| Khattab, AEA | 1 |
| Darwish, AM | 1 |
| Al-Omar, MA | 1 |
| Naglah, AM | 1 |
| Bhat, MA | 1 |
| Kalmouch, A | 1 |
| Erdem, N | 1 |
| Çizmecioğlu, A | 1 |
| Aydoğdu, İ | 3 |
| Julião, M | 1 |
| Cunha, I | 1 |
| Costa, A | 1 |
| Hamilton, B | 1 |
| Fowler, P | 1 |
| Galloway, H | 1 |
| Popovic, N | 1 |
| Uri, O | 1 |
| Arad, E | 1 |
| Okan, G | 1 |
| Canter, HI | 1 |
| Marangi, GF | 1 |
| Gigliofiorito, P | 1 |
| Toto, V | 1 |
| Langella, M | 1 |
| Pallara, T | 1 |
| Persichetti, P | 1 |
| Bao, H | 1 |
| Ge, Y | 1 |
| Zhuang, S | 1 |
| Dworkin, LD | 1 |
| Liu, Z | 1 |
| Gong, R | 1 |
| Yano, A | 1 |
| Higuchi, S | 1 |
| Tsuneyama, K | 1 |
| Fukami, T | 1 |
| Nakajima, M | 1 |
| Yokoi, T | 1 |
| Meuleman, C | 1 |
| Jourdain, P | 1 |
| Bellorini, M | 1 |
| Guillard, N | 1 |
| Loiret, J | 1 |
| Thebault, B | 1 |
| Sadeg, N | 1 |
| Funck, F | 1 |
| Palop Larrea, V | 1 |
| Belenguer Varea, A | 1 |
| Cuesta Romero, C | 1 |
| Mallent Añón, J | 1 |
| Mayrink, M | 1 |
| Mendonça, AC | 1 |
| da Costa, PR | 1 |
| Miyabara, EH | 1 |
| Tostes, RC | 1 |
| Selistre de Araújo, HS | 1 |
| Aoki, MS | 1 |
| Salvini, TF | 1 |
| Moriscot, AS | 1 |
| Bajaj, DR | 1 |
| Qureshi, AA | 1 |
| Kekilli, E | 1 |
| Yagmur, C | 1 |
| Kaya, E | 2 |
| Kuku, I | 2 |
| Ertem, K | 1 |
| Erkurt, MA | 1 |
| Ozhan, O | 1 |
| Yitmen, E | 1 |
| Aydin, NE | 1 |
| Lie, C | 1 |
| Leung, F | 1 |
| Chow, SP | 1 |
| Mutalik, S | 1 |
| Belgaumkar, V | 1 |
| Pandhi, D | 1 |
| Mehta, S | 1 |
| Agrawal, S | 1 |
| Singal, A | 1 |
| Sarifakioglu, E | 1 |
| Senel, E | 1 |
| Ada, S | 1 |
| Güleç, AT | 1 |
| Cağlar, B | 1 |
| Pillans, PI | 1 |
| O'Connor, N | 1 |
| Rowan, JA | 1 |
| North, RA | 1 |
| Bulbena, O | 1 |
| Escolar, G | 1 |
| Navarro, C | 1 |
| Bravo, L | 1 |
| Pfeiffer, CJ | 1 |
| Rygnestad, T | 1 |
| Kvam, AM | 1 |
| Köhler, LD | 1 |
| Schwedler, S | 1 |
| Worret, WI | 1 |
| Seed, MP | 1 |
| Freemantle, CN | 1 |
| Alam, CA | 1 |
| Colville-Nash, PR | 1 |
| Brown, JR | 1 |
| Papworth, JL | 1 |
| Somerville, KW | 1 |
| Willoughby, DA | 1 |
| Zenker, M | 1 |
| Klinge, J | 1 |
| Krüger, C | 1 |
| Singer, H | 1 |
| Scharf, J | 1 |
| Hickey, EJ | 1 |
| Raje, RR | 1 |
| Reid, VE | 1 |
| Gross, SM | 1 |
| Ray, SD | 1 |
| Stricker, BH | 1 |
| van Kasteren, BJ | 1 |
| Helfgott, SM | 1 |
| Sandberg-Cook, J | 1 |
| Zakim, D | 1 |
| Nestler, J | 1 |
| Koide, T | 1 |
| Wieloch, TW | 1 |
| Siesjö, BK | 1 |
1 review available for diclofenac and Necrosis
| Article | Year |
|---|---|
Soft-tissue sarcoma arising from a tissue necrosis caused by an intramuscular injection of diclofenac.
Topics: Buttocks; Diclofenac; Female; Humans; Injections, Intramuscular; Middle Aged; Necrosis; Sarcoma; Ski | 2003 |
31 other studies available for diclofenac and Necrosis
| Article | Year |
|---|---|
Anti-inflammatory activity of novel derivatives of pyrazolo [3,4d] pyridazine against digestive system inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Dioxide; Colitis; Colon; Diclofenac; Disease | 2023 |
From Bone Marrow Necrosis to Gaucher Disease; A Long Way to Run.
Topics: Bone Marrow; Bone Marrow Examination; Diagnostic Errors; Diclofenac; Gaucher Disease; Glucosylcerami | 2015 |
Skin Necrosis after Subcutaneous Diclofenac Administration: A Case Report.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Injections, | 2016 |
Nicolau syndrome in an athlete following intra-muscular diclofenac injection.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diclofenac; Drug Eruptions; Heparin, | 2008 |
Skin necrosis after self-administered intramuscular diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Cellulitis; Diclofenac; Humans; Injections, Intr | 2010 |
Nicolau syndrome and perforator vessels: a new viewpoint for an old problem.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Debridement; Diclofenac; Drug | 2010 |
Three cases of embolia cutis medicamentosa (Nicolau's syndrome).
Topics: Aged; Diclofenac; Fat Necrosis; Female; Humans; Injections, Intramuscular; Ketorolac; Middle Aged; N | 2010 |
Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopt | 2012 |
Involvement of immune-related factors in diclofenac-induced acute liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; | 2012 |
[Anaphylactic shock and myocytic necrosis after treatment with Artotec].
Topics: Aged; Anaphylaxis; Anti-Ulcer Agents; Diclofenac; Humans; Male; Misoprostol; Myocardium; Necrosis | 2002 |
[Intramuscular aceclofenac and necrosis at the point of injection with fatal outcome].
Topics: Abscess; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drainage; Fat | 2003 |
Cyclosporin A attenuates skeletal muscle damage induced by crotoxin in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcineurin Inhibitors; Crotoxin; Cyclosporine; Di | 2004 |
Embolia cutis medicamentosa.
Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Diclofenac; Drug Hypersensitivity; Female; Fo | 2005 |
Decreased Tc-99m MDP uptake in myelonecrosis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Diseases; Diclofenac; Humans; Male; Necr | 2006 |
Reversible bone marrow necrosis in a patient due to overdosage of diclofenac sodium.
Topics: Adult; Bone Marrow; Bone Marrow Diseases; Cyclooxygenase Inhibitors; Diclofenac; Humans; Male; Necro | 2006 |
Nicolau syndrome following intramuscular diclofenac administration: a case report.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Eruptions; Fat Necrosis; Humans; Injection | 2006 |
Nicolau syndrome: a report of 2 cases.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Injections, Intramuscular; Male; | 2006 |
Erythema nodosum leprosum necroticans in a child--an unusual manifestation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Diclofenac; Drug Therapy, Combination; Erythema Nodo | 2005 |
Nicolau syndrome after diclofenac injection.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Buttocks; Diclofenac; Erythema; Female; Humans; | 2007 |
Nicolau syndrome aggravated by cold application after i.m. diclofenac.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Buttocks; Cold Temperature; Diclofenac; Drug Eruptions; Fem | 2008 |
Tissue necrosis and necrotizing fasciitis after intramuscular administration of diclofenac.
Topics: Adult; Diclofenac; Fasciitis; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Necrosis | 1995 |
Necrotizing fasciitis in the puerperium.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fasciitis; Female; Humans; Necrosis; Pue | 1995 |
Gastroprotective effect of zinc acexamate against damage induced by nonsteroidal antiinflammatory drugs. A morphological study.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen | 1993 |
Streptococcal myositis and tissue necrosis with intramuscular administration of diclofenac (Voltaren).
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Injections, Intramuscular; Male; | 1995 |
Embolia cutis medicamentosa.
Topics: Adult; Dexamethasone; Diclofenac; Drug Eruptions; Embolism; Humans; Injections, Intramuscular; Male; | 1997 |
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm | 1997 |
Severe pulmonary hypertension in a neonate caused by premature closure of the ductus arteriosus following maternal treatment with diclofenac: a case report.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ductus Arteriosus; Female; Humans; Hypertension | 1998 |
Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Diclofenac; DNA Fragmentation; Endodeox | 2001 |
Diclofenac-induced isolated myonecrosis and the Nicolau syndrome.
Topics: Adult; Diclofenac; Humans; Injections, Intramuscular; Ischemia; Male; Muscular Diseases; Necrosis; S | 1992 |
Diclofenac-associated hepatotoxicity.
Topics: Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Diclofenac; Female; Fibromyalgi | 1990 |
Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis.
Topics: Animals; Blood Glucose; Brain Chemistry; Brain Ischemia; Cyclooxygenase Inhibitors; Dexamethasone; D | 1986 |