Page last updated: 2024-08-07 15:18:58
tyrosine-protein kinase Yes
[no definition available]
Synonyms
Research
Bioassay Publications (1)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (182)
Drugs with Potency Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pd 173074 | Homo sapiens (human) | Potency | 9.7232 | 1 | 1 |
| abt 702 | Homo sapiens (human) | Potency | 3.4499 | 1 | 1 |
| bicalutamide | Homo sapiens (human) | Potency | 21.7676 | 1 | 1 |
| gossypol | Homo sapiens (human) | Potency | 30.7475 | 1 | 1 |
| indirubin-3'-monoxime | Homo sapiens (human) | Potency | 0.7723 | 1 | 1 |
| lg 100268 | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| mitoxantrone | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| entinostat | Homo sapiens (human) | Potency | 15.4103 | 1 | 1 |
| pioglitazone | Homo sapiens (human) | Potency | 1.7291 | 1 | 1 |
| 3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one | Homo sapiens (human) | Potency | 5.8246 | 1 | 1 |
| sb 220025 | Homo sapiens (human) | Potency | 4.3010 | 1 | 2 |
| sb 202190 | Homo sapiens (human) | Potency | 17.2906 | 1 | 1 |
| sk&f 86002 | Homo sapiens (human) | Potency | 0.5191 | 1 | 1 |
| imatinib | Homo sapiens (human) | Potency | 27.4038 | 1 | 1 |
| formestane | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| cladribine | Homo sapiens (human) | Potency | 79.2586 | 1 | 1 |
| zidovudine | Homo sapiens (human) | Potency | 43.4320 | 1 | 1 |
| pravadoline | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| topotecan | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| ubenimex | Homo sapiens (human) | Potency | 54.6777 | 1 | 1 |
| elacridar | Homo sapiens (human) | Potency | 1.5410 | 1 | 1 |
| gefitinib | Homo sapiens (human) | Potency | 1.5512 | 1 | 2 |
| gyki 53655 | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| canertinib | Homo sapiens (human) | Potency | 0.1729 | 1 | 1 |
| birb 796 | Homo sapiens (human) | Potency | 21.7676 | 1 | 1 |
| cyc 202 | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| sb 203580 | Homo sapiens (human) | Potency | 10.9096 | 1 | 1 |
| erlotinib | Homo sapiens (human) | Potency | 0.9723 | 1 | 1 |
| l 163191 | Homo sapiens (human) | Potency | 12.2408 | 1 | 1 |
| lapatinib | Homo sapiens (human) | Potency | 4.3432 | 1 | 1 |
| sorafenib | Homo sapiens (human) | Potency | 30.9516 | 1 | 2 |
| N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide | Homo sapiens (human) | Potency | 0.0434 | 1 | 1 |
| nsc 663284 | Homo sapiens (human) | Potency | 6.8835 | 1 | 1 |
| gw 3965 | Homo sapiens (human) | Potency | 54.6777 | 1 | 1 |
| 6-bromoindirubin-3'-oxime | Homo sapiens (human) | Potency | 0.1541 | 1 | 1 |
| purvalanol b | Homo sapiens (human) | Potency | 0.0194 | 1 | 1 |
| repsox | Homo sapiens (human) | Potency | 2.5765 | 1 | 2 |
| 4,4-difluoro-N-[(1S)-3-[3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]-1-cyclohexanecarboxamide | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| cct018159 | Homo sapiens (human) | Potency | 4.3432 | 1 | 1 |
| rwj 67657 | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| bms 387032 | Homo sapiens (human) | Potency | 43.4320 | 1 | 1 |
| tandutinib | Homo sapiens (human) | Potency | 43.4320 | 1 | 1 |
| dasatinib | Homo sapiens (human) | Potency | 0.0024 | 1 | 1 |
| zd 6474 | Homo sapiens (human) | Potency | 0.0613 | 1 | 1 |
| sb-224289 | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| gw 7647 | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| l 663536 | Homo sapiens (human) | Potency | 48.7315 | 1 | 1 |
| 1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| 2-[[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester | Homo sapiens (human) | Potency | 21.7676 | 1 | 1 |
| sch 79797 | Homo sapiens (human) | Potency | 0.1373 | 1 | 1 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide | Homo sapiens (human) | Potency | 58.2458 | 1 | 1 |
| ex 527 | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| quercetin | Homo sapiens (human) | Potency | 15.4103 | 1 | 1 |
| genistein | Homo sapiens (human) | Potency | 30.7475 | 1 | 1 |
| pd 166285 | Homo sapiens (human) | Potency | 0.0002 | 2 | 1 |
| su 6656 | Homo sapiens (human) | Potency | 0.0972 | 1 | 1 |
| semaxinib | Homo sapiens (human) | Potency | 1.3734 | 1 | 1 |
| su 11248 | Homo sapiens (human) | Potency | 0.0487 | 1 | 1 |
| palbociclib | Homo sapiens (human) | Potency | 6.8835 | 1 | 1 |
| jnj-7706621 | Homo sapiens (human) | Potency | 0.7723 | 1 | 1 |
| vx680 | Homo sapiens (human) | Potency | 0.2922 | 1 | 2 |
| d 4476 | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| cyc 116 | Homo sapiens (human) | Potency | 0.3075 | 1 | 1 |
| axitinib | Homo sapiens (human) | Potency | 0.6884 | 1 | 1 |
| pai 039 | Homo sapiens (human) | Potency | 43.4320 | 1 | 1 |
| gw2974 | Homo sapiens (human) | Potency | 0.2067 | 1 | 1 |
| bibx 1382bs | Homo sapiens (human) | Potency | 3.4499 | 1 | 1 |
| [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone | Homo sapiens (human) | Potency | 0.0688 | 1 | 1 |
| iniparib | Homo sapiens (human) | Potency | 43.4320 | 1 | 1 |
| av 412 | Homo sapiens (human) | Potency | 0.0972 | 1 | 1 |
| telatinib | Homo sapiens (human) | Potency | 5.4678 | 1 | 1 |
| cp 547632 | Homo sapiens (human) | Potency | 0.0019 | 1 | 1 |
| lenvatinib | Homo sapiens (human) | Potency | 3.4499 | 1 | 1 |
| gw843682x | Homo sapiens (human) | Potency | 20.6664 | 1 | 1 |
| midostaurin | Homo sapiens (human) | Potency | 0.1091 | 1 | 1 |
| ag 14361 | Homo sapiens (human) | Potency | 13.7344 | 1 | 1 |
| sb 265610 | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| fr 148083 | Homo sapiens (human) | Potency | 2.4424 | 1 | 1 |
| osi 930 | Homo sapiens (human) | Potency | 30.7475 | 1 | 1 |
| ki 20227 | Homo sapiens (human) | Potency | 2.4424 | 1 | 1 |
| sb 210313 | Homo sapiens (human) | Potency | 51.9116 | 1 | 1 |
| gw 4064 | Homo sapiens (human) | Potency | 43.4320 | 1 | 1 |
| sa 4503 | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| tivozanib | Homo sapiens (human) | Potency | 0.7723 | 1 | 1 |
| hki 272 | Homo sapiens (human) | Potency | 0.0137 | 1 | 1 |
| tofacitinib | Homo sapiens (human) | Potency | 8.6658 | 1 | 1 |
| rucaparib | Homo sapiens (human) | Potency | 0.3075 | 1 | 1 |
| cediranib | Homo sapiens (human) | Potency | 0.0434 | 1 | 1 |
| chir 99021 | Homo sapiens (human) | Potency | 30.7475 | 1 | 1 |
| sb 525334 | Homo sapiens (human) | Potency | 0.6884 | 1 | 1 |
| masitinib | Homo sapiens (human) | Potency | 0.3450 | 1 | 1 |
| bx795 | Homo sapiens (human) | Potency | 1.2988 | 1 | 2 |
| pazopanib | Homo sapiens (human) | Potency | 0.3075 | 1 | 1 |
| N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide | Homo sapiens (human) | Potency | 58.2458 | 1 | 1 |
| aee 788 | Homo sapiens (human) | Potency | 0.0101 | 2 | 1 |
| saracatinib | Homo sapiens (human) | Potency | 0.0033 | 2 | 1 |
| azd 7762 | Homo sapiens (human) | Potency | 0.0019 | 1 | 1 |
| krp-203 | Homo sapiens (human) | Potency | 54.6777 | 1 | 1 |
| regorafenib | Homo sapiens (human) | Potency | 4.8732 | 1 | 1 |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Homo sapiens (human) | Potency | 0.8522 | 1 | 2 |
| brivanib | Homo sapiens (human) | Potency | 1.7291 | 1 | 1 |
| nu 7441 | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| at 7519 | Homo sapiens (human) | Potency | 17.2906 | 1 | 1 |
| bi 2536 | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| danusertib | Homo sapiens (human) | Potency | 0.0073 | 2 | 1 |
| N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide | Homo sapiens (human) | Potency | 6.8835 | 1 | 1 |
| N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide | Homo sapiens (human) | Potency | 0.0547 | 1 | 1 |
| abt 869 | Homo sapiens (human) | Potency | 4.8732 | 1 | 1 |
| dorsomorphin | Homo sapiens (human) | Potency | 0.1253 | 2 | 1 |
| ac 261066 | Homo sapiens (human) | Potency | 48.7315 | 1 | 1 |
| pf 573228 | Homo sapiens (human) | Potency | 0.9723 | 1 | 1 |
| gw 2580 | Homo sapiens (human) | Potency | 46.2663 | 1 | 1 |
| crizotinib | Homo sapiens (human) | Potency | 0.6884 | 1 | 1 |
| 5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile | Homo sapiens (human) | Potency | 0.2319 | 1 | 1 |
| osi 906 | Homo sapiens (human) | Potency | 1.7291 | 1 | 1 |
| ly2109761 | Homo sapiens (human) | Potency | 8.6658 | 1 | 1 |
| chir-265 | Homo sapiens (human) | Potency | 2.4424 | 1 | 1 |
| motesanib | Homo sapiens (human) | Potency | 13.7344 | 1 | 1 |
| az-628 | Homo sapiens (human) | Potency | 0.2128 | 2 | 1 |
| pf-562,271 | Homo sapiens (human) | Potency | 0.1940 | 1 | 1 |
| palomid 529 | Homo sapiens (human) | Potency | 61.3494 | 1 | 1 |
| ku 60019 | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| gsk 461364 | Homo sapiens (human) | Potency | 1.3734 | 1 | 1 |
| nvp-tae684 | Homo sapiens (human) | Potency | 0.0055 | 1 | 1 |
| 4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6-yl)-n-(3-(trifluoromethyl)phenyl)benzamide | Homo sapiens (human) | Potency | 0.0042 | 2 | 1 |
| gsk 269962a | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| a-83-01 | Homo sapiens (human) | Potency | 2.4424 | 1 | 1 |
| 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one | Homo sapiens (human) | Potency | 0.5191 | 1 | 1 |
| azd 1480 | Homo sapiens (human) | Potency | 0.7723 | 1 | 1 |
| gsk690693 | Homo sapiens (human) | Potency | 24.4236 | 1 | 1 |
| nutlin-3b | Homo sapiens (human) | Potency | 12.2408 | 1 | 1 |
| pf 04217903 | Homo sapiens (human) | Potency | 61.3494 | 1 | 2 |
| gdc 0941 | Homo sapiens (human) | Potency | 30.7475 | 1 | 1 |
| plx 4720 | Homo sapiens (human) | Potency | 0.1729 | 1 | 1 |
| cx 4945 | Homo sapiens (human) | Potency | 0.4873 | 1 | 1 |
| cudc 101 | Homo sapiens (human) | Potency | 1.7291 | 1 | 1 |
| mln 8237 | Homo sapiens (human) | Potency | 0.0218 | 1 | 1 |
| bms 777607 | Homo sapiens (human) | Potency | 1.9400 | 1 | 1 |
| sgi 1776 | Homo sapiens (human) | Potency | 1.4320 | 2 | 1 |
| pci 32765 | Homo sapiens (human) | Potency | 0.0013 | 2 | 1 |
| ponatinib | Homo sapiens (human) | Potency | 0.0012 | 2 | 1 |
| amg 900 | Homo sapiens (human) | Potency | 48.7315 | 1 | 1 |
| mk-1775 | Homo sapiens (human) | Potency | 0.0434 | 1 | 1 |
| bag956 | Homo sapiens (human) | Potency | 2.1768 | 1 | 1 |
| mk 2206 | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| navitoclax | Homo sapiens (human) | Potency | 30.7475 | 1 | 1 |
| jzl 184 | Homo sapiens (human) | Potency | 2.4424 | 1 | 1 |
| n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide | Homo sapiens (human) | Potency | 0.9723 | 1 | 1 |
| dcc-2036 | Homo sapiens (human) | Potency | 0.0099 | 2 | 1 |
| cabozantinib | Homo sapiens (human) | Potency | 1.0910 | 1 | 1 |
| N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide | Homo sapiens (human) | Potency | 43.4320 | 1 | 1 |
| incb-018424 | Homo sapiens (human) | Potency | 2.4424 | 1 | 1 |
| gsk 2126458 | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| ldn 193189 | Homo sapiens (human) | Potency | 0.1373 | 1 | 1 |
| plx4032 | Homo sapiens (human) | Potency | 1.3734 | 1 | 1 |
| gsk 1363089 | Homo sapiens (human) | Potency | 0.1940 | 1 | 1 |
| bay 869766 | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| 4-[6-[4-(methoxycarbonylamino)phenyl]-4-(4-morpholinyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinecarboxylic acid methyl ester | Homo sapiens (human) | Potency | 19.4004 | 1 | 1 |
| cp 466722 | Homo sapiens (human) | Potency | 2.7404 | 1 | 1 |
| CAY10626 | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| thiopental sodium | Homo sapiens (human) | Potency | 4.8732 | 1 | 1 |
| pha 793887 | Homo sapiens (human) | Potency | 12.2408 | 1 | 1 |
| nvp-bsk805 | Homo sapiens (human) | Potency | 0.3075 | 1 | 1 |
| gsk4112 | Homo sapiens (human) | Potency | 54.6777 | 1 | 1 |
| torin 2 | Homo sapiens (human) | Potency | 27.4038 | 1 | 1 |
| 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide | Homo sapiens (human) | Potency | 5.4678 | 1 | 1 |
| belinostat | Homo sapiens (human) | Potency | 0.0017 | 1 | 1 |
| LimKi 3 | Homo sapiens (human) | Potency | 27.4038 | 1 | 1 |
| 2-[5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxy-2-pyrrolylidene]indole | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]-2-propenamide | Homo sapiens (human) | Potency | 13.7344 | 1 | 1 |
| gsk837149a | Homo sapiens (human) | Potency | 24.4236 | 1 | 1 |
| N-[4-(3-chloro-4-fluoroanilino)-7-[[(3S)-3-oxolanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide | Homo sapiens (human) | Potency | 0.0613 | 1 | 1 |
| N-[4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide | Homo sapiens (human) | Potency | 0.1940 | 1 | 1 |
| wnt-c59 | Homo sapiens (human) | Potency | 9.7232 | 1 | 1 |
| 5-[1-(2-hydroxyethyl)-3-pyridin-4-yl-4-pyrazolyl]-2,3-dihydroinden-1-one oxime | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| chir 258 | Homo sapiens (human) | Potency | 0.0241 | 2 | 1 |
| osi 027 | Homo sapiens (human) | Potency | 0.0688 | 1 | 1 |
| pemetrexed | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| nintedanib | Homo sapiens (human) | Potency | 0.0056 | 2 | 1 |
| ver 52296 | Homo sapiens (human) | Potency | 38.7088 | 1 | 1 |
| sb-590885 | Homo sapiens (human) | Potency | 2.9192 | 1 | 1 |
| pf-477736 | Homo sapiens (human) | Potency | 0.0867 | 1 | 1 |