Sodium/potassium-transporting ATPase subunit alpha-1

A sodium/potassium-transporting ATPase subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05023]

Synonyms

Na(+)/K(+) ATPase alpha-1 subunit;
EC 7.2.2.13;
Sodium pump subunit alpha-1

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (7.69)	18.7374
1990's	3 (23.08)	18.2507
2000's	3 (23.08)	29.6817
2010's	6 (46.15)	24.3611
2020's	0 (0.00)	2.80

Compounds (14)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
lansoprazole	Homo sapiens (human)	IC50	39.8107	1	1
omeprazole	Homo sapiens (human)	IC50	31.6228	1	1
pantoprazole	Homo sapiens (human)	IC50	199.5260	1	1
digoxigenin	Homo sapiens (human)	Ki	0.1345	1	2
digoxigenin-bis(digitoxoside)	Homo sapiens (human)	Ki	0.1350	1	2
rostafuroxin	Homo sapiens (human)	IC50	1.5000	1	1
ouabain	Homo sapiens (human)	IC50	6.0000	1	1
ouabain	Homo sapiens (human)	Ki	0.0935	1	2
digitoxin	Homo sapiens (human)	IC50	0.0080	1	1
digoxin	Homo sapiens (human)	IC50	0.3200	3	3
digoxin	Homo sapiens (human)	Ki	0.1220	1	2
digitoxigenin	Homo sapiens (human)	IC50	0.1673	5	6
phakellistatin 2	Homo sapiens (human)	IC50	100.0000	1	1
digitoxigenin monodigitoxoside	Homo sapiens (human)	IC50	0.0070	1	1
evomonoside	Homo sapiens (human)	IC50	0.0058	1	2
halisulfate 1	Homo sapiens (human)	IC50	3.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ouabain	Homo sapiens (human)	LC50	9.4000	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
P-type sodium:potassium-exchanging transporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). [EC:7.2.2.13]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
phosphatase activity	molecular function	Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg]
ATP hydrolysis activity	molecular function	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]
potassium ion binding	molecular function	Binding to a potassium ion (K+). [GOC:mah]
sodium ion binding	molecular function	Binding to a sodium ion (Na+). [GOC:mah]
transmembrane transporter binding	molecular function	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]
protein-folding chaperone binding	molecular function	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]
steroid hormone binding	molecular function	Binding to a steroid hormone. [GOC:ln]

Located In

This protein is located in 18 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
lateral plasma membrane	cellular component	The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr]
T-tubule	cellular component	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194]
axon	cellular component	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
organelle membrane	cellular component	A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. [GOC:dos, GOC:mah]
sperm flagellum	cellular component	A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. [GOC:cilia, GOC:sart, PMID:8441407]
sarcolemma	cellular component	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]
melanosome	cellular component	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301]
membrane raft	cellular component	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]
photoreceptor inner segment membrane	cellular component	The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. [GOC:dph]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
extracellular vesicle	cellular component	Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
sarcolemma	cellular component	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
sodium:potassium-exchanging ATPase complex	cellular component	Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732]
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 22 target(s):

Target	Category	Definition
regulation of the force of heart contraction	biological process	Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. [GOC:dph, GOC:tb, PMID:10358008]
regulation of sodium ion transport	biological process	Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph]
intracellular sodium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah]
osmosensory signaling pathway	biological process	The series of molecular signals initiated in response to osmotic change. [GOC:jl]
regulation of blood pressure	biological process	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
establishment or maintenance of transmembrane electrochemical gradient	biological process	The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. [GOC:mah, GOC:sm]
intracellular potassium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah]
negative regulation of glucocorticoid biosynthetic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. [GOC:mah]
sodium ion export across plasma membrane	biological process	The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]
negative regulation of heart contraction	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. [GOC:go_curators]
positive regulation of heart contraction	biological process	Any process that activates or increases the frequency, rate or extent of heart contraction. [GOC:go_curators]
positive regulation of striated muscle contraction	biological process	Any process that activates or increases the frequency, rate or extent of striated muscle contraction. [GOC:go_curators]
relaxation of cardiac muscle	biological process	The process in which the extent of cardiac muscle contraction is reduced. [GOC:ecd]
cellular response to steroid hormone stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. [GOC:mah]
cardiac muscle cell action potential involved in contraction	biological process	An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane repolarization	biological process	The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane repolarization during cardiac muscle cell action potential	biological process	The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
cell communication by electrical coupling involved in cardiac conduction	biological process	The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
proton transmembrane transport	biological process	The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie]
response to glycoside	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus. [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970]
potassium ion import across plasma membrane	biological process	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]