Compounds > 18f-fluoroethyl-l-tyrosine
Page last updated: 2024-11-11

18f-fluoroethyl-l-tyrosine

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Description

(18F)fluoroethyltyrosine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9834479
CHEMBL ID477278
SCHEMBL ID11939889
MeSH IDM000598977

Synonyms (29)

Synonym
j1.857.391a
(18f)fluoroethyltyrosine
fet f-18
fluoroethyltyrosine f-18
o-(2-fluoroethyl)-l-tyrosine f-18
2-fluoroethyltyrosine f-18
CHEMBL477278
18f-fet
fluoroethyl-l-tyrosine (18f)
SCHEMBL11939889
fluoroethyl-l-tyrosine (18f) [who-dd]
o-(2-(18f)fluoroethyl)-l-tyrosine
1325243-02-4
o-(2-[18f]fluoroethyl)-l-tyrosine
1326R5J1IA ,
(s)-2-amino-3-(4-(2-(fluoro-18f)ethoxy)phenyl)propanoic acid
l-tyrosine, o-(2-(fluoro-18f)ethyl)-
o-(2-fluoroethyl)-l-tyrosine-18f
18f-fluoroethyl-l-tyrosine
178433-03-9
unii-1326r5j1ia
18f-fluoroethyltyrosine
DB15405
Q22908451
o-(2-fluorethyl)-l-thyrosine
(2s)-2-amino-3-[4-(2-(18f)fluoranylethoxy)phenyl]propanoic acid
l-tyrosine, o-[2-(fluoro-18f)ethyl]-
DTXSID601045942
AKOS040751800

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The tissue segmentation relies on population pharmacokinetic modeling with dependent individuals (voxels)."( Population Pharmacokinetic Approach Applied to Positron Emission Tomography: Computed Tomography for Tumor Tissue Identification in Patients with Glioma.
Chatelut, E; Concordet, D; de Mey, J; de Ridder, M; Duerinck, J; Everaert, H; Gandia, P; Heemskerk, J; Jaudet, C; Neyns, B; Vanbinst, AM, 2017)		0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (90)

Assay IDTitleYearJournalArticle
AID476256Ratio of drug uptake in tumor to brain of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID654057Drug uptake in mouse EMT6 tumor xenografted in Balb/c mouse after 30 mins by PET analysis2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
AID476248Biodistribution in mouse S180 cells xenografted Kunming mouse kidney at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476419Ratio of drug uptake in tumor to blood of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476221Biodistribution in mouse S180 cells xenografted Kunming mouse lung at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476217Ratio of drug uptake in tumor to brain of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID609651Cellular uptake in mouse S180 cells relative to [18F]FDG2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Synthesis and biological evaluation of novel F-18 labeled pyrazolo[1,5-a]pyrimidine derivatives: potential PET imaging agents for tumor detection.
AID382233Biodistribution in muscle of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476233Biodistribution in mouse S180 cells xenografted Kunming mouse pancreas at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476418Biodistribution in mouse S180 cells xenografted Kunming mouse tumor at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476242Ratio of drug uptake in tumor to muscle of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382229Biodistribution in heart of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476225Biodistribution in mouse S180 cells xenografted Kunming mouse blood at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476238Biodistribution in mouse S180 cells xenografted Kunming mouse blood at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476212Biodistribution in mouse S180 cells xenografted Kunming mouse blood at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476207Biodistribution in mouse S180 cells xenografted Kunming mouse pancreas at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476228Ratio of drug uptake in tumor to blood of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382218Biodistribution in kidney of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476216Ratio of drug uptake in tumor to muscle of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476259Biodistribution in mouse S180 cells xenografted Kunming mouse pancreas at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476254Ratio of drug uptake in tumor to blood of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382224Biodistribution in muscle of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476247Biodistribution in mouse S180 cells xenografted Kunming mouse lung at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382222Biodistribution in urinary bladder of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476243Ratio of drug uptake in tumor to brain of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476231Biodistribution in mouse S180 cells xenografted Kunming mouse heart at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476421Ratio of drug uptake in tumor to brain of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID654058Drug uptake in mouse EMT6 tumor xenografted in Balb/c mouse after 60 mins by PET analysis2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
AID476211Biodistribution in mouse S180 cells xenografted Kunming mouse muscle at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476244Biodistribution in mouse S180 cells xenografted Kunming mouse heart at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382223Biodistribution in brain of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID382219Biodistribution in blood of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476241Ratio of drug uptake in tumor to blood of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476227Biodistribution in mouse S180 cells xenografted Kunming mouse tumor at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382228Biodistribution in kidney of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476205Biodistribution in mouse S180 cells xenografted Kunming mouse heart at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID724111Stability of the compound in rat plasma at 22 MBq/mL up to 120 mins2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Investigations into the synthesis, radiofluorination and conjugation of a new [¹⁸F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system.
AID476229Ratio of drug uptake in tumor to muscle of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382232Biodistribution in brain of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID724110Stability of the compound in human plasma at 22 MBq/mL up to 120 mins2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Investigations into the synthesis, radiofluorination and conjugation of a new [¹⁸F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system.
AID382221Biodistribution in liver of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476246Biodistribution in mouse S180 cells xenografted Kunming mouse pancreas at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID654056Drug uptake in mouse EMT6 tumor xenografted in Balb/c mouse assessed per mg of protein after 100 mins by PET analysis2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
AID476235Biodistribution in mouse S180 cells xenografted Kunming mouse kidney at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382234Biodistribution in abscess of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID609652Cellular uptake in mouse S180 cells after 60 mins2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Synthesis and biological evaluation of novel F-18 labeled pyrazolo[1,5-a]pyrimidine derivatives: potential PET imaging agents for tumor detection.
AID476234Biodistribution in mouse S180 cells xenografted Kunming mouse lung at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382231Biodistribution in urinary bladder of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476220Biodistribution in mouse S180 cells xenografted Kunming mouse pancreas at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476263Biodistribution in mouse S180 cells xenografted Kunming mouse muscle at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476237Biodistribution in mouse S180 cells xenografted Kunming mouse muscle at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382230Biodistribution in liver of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID654059Drug uptake in Balb/c mouse muscle after 10 mins by PET analysis2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
AID654061Ratio of drug uptake in tumor to muscle of Balb/c mouse after 60 mins post infection by PET analysis2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
AID476258Biodistribution in mouse S180 cells xenografted Kunming mouse liver at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382227Biodistribution in blood of Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476253Biodistribution in mouse S180 cells xenografted Kunming mouse tumor at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID654055Drug uptake in mouse EMT6 tumor xenografted in Balb/c mouse assessed per mg of protein after 15 mins by PET analysis2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
AID476260Biodistribution in mouse S180 cells xenografted Kunming mouse lung at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476218Biodistribution in mouse S180 cells xenografted Kunming mouse heart at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476232Biodistribution in mouse S180 cells xenografted Kunming mouse liver at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476230Ratio of drug uptake in tumor to brain of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382225Biodistribution in tumor of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476239Biodistribution in mouse S180 cells xenografted Kunming mouse brain at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476213Biodistribution in mouse S180 cells xenografted Kunming mouse brain at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476261Biodistribution in mouse S180 cells xenografted Kunming mouse kidney at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476245Biodistribution in mouse S180 cells xenografted Kunming mouse liver at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476250Biodistribution in mouse S180 cells xenografted Kunming mouse muscle at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382226Ratio of drug level in tumor to muscle in Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476219Biodistribution in mouse S180 cells xenografted Kunming mouse liver at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID654060Drug uptake in Balb/c mouse muscle after 30 to 60 mins by PET analysis2012Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET).
AID476215Ratio of drug uptake in tumor to blood of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476214Biodistribution in mouse S180 cells xenografted Kunming mouse tumor at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476240Biodistribution in mouse S180 cells xenografted Kunming mouse tumor at 10 to 20 uCi, iv after 30 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476222Biodistribution in mouse S180 cells xenografted Kunming mouse kidney at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476257Biodistribution in mouse S180 cells xenografted Kunming mouse heart at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476264Biodistribution in mouse S180 cells xenografted Kunming mouse blood at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382220Biodistribution in heart of Wistar rat bearing glioma35 rat tumor at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476208Biodistribution in mouse S180 cells xenografted Kunming mouse lung at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476420Ratio of drug uptake in tumor to muscle of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476265Biodistribution in mouse S180 cells xenografted Kunming mouse brain at 10 to 20 uCi, iv after 120 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476224Biodistribution in mouse S180 cells xenografted Kunming mouse muscle at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID382235Ratio of drug level in abscess to muscle in Wistar rat bearing turpentine-induced aseptic abscess at 150-180 uCi after 40 mins2008Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.
AID476252Biodistribution in mouse S180 cells xenografted Kunming mouse brain at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476206Biodistribution in mouse S180 cells xenografted Kunming mouse liver at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID724109Stability of the compound in human plasma at 22 MBq/mL after 5 mins2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Investigations into the synthesis, radiofluorination and conjugation of a new [¹⁸F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system.
AID476251Biodistribution in mouse S180 cells xenografted Kunming mouse blood at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476209Biodistribution in mouse S180 cells xenografted Kunming mouse kidney at 10 to 20 uCi, iv after 5 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476255Ratio of drug uptake in tumor to muscle of mouse S180 cells xenografted Kunming mouse at 10 to 20 uCi, iv after 60 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
AID476226Biodistribution in mouse S180 cells xenografted Kunming mouse brain at 10 to 20 uCi, iv after 15 mins by gamma counting2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
(18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (116)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (0.86)29.6817
2010's103 (88.79)24.3611
2020's12 (10.34)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.71 (24.57)
Research Supply Index4.88 (2.92)
Research Growth Index6.51 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials8 (6.56%)5.53%
Reviews10 (8.20%)6.00%
Case Studies11 (9.02%)4.05%
Observational0 (0.00%)0.25%
Other93 (76.23%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aminolevulinic acid
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.. 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.		4.43414-oxo monocarboxylic acid;
amino acid zwitterion;
delta-amino acid		antineoplastic agent;
dermatologic drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
choline
[no description available]		3.3760cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
dihydroxyphenylalanine
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.. dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.		4.8450hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.110aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
lomustine
[no description available]		3.5611N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent
protoporphyrin ix
protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685. protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.		2.4110
temozolomide
[no description available]		4.1931imidazotetrazine;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent;
prodrug
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.0810alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		14.731128amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		4.830aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.1510erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.110pyrrole;
secondary amine
azomycin
azomycin: RN given refers to parent cpd with specified locant; structure		2.2110C-nitro compound;
imidazoles		antitubercular agent
gadolinium
Gadolinium: An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.		5.3541f-block element atom;
lanthanoid atom
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.4920delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		3.0410glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
alovudine
[no description available]		2.830pyrimidine 2',3'-dideoxyribonucleoside
fluorodopa f 18
fluorodopa F 18: RN given refers to (L)-isomer		4.8450(18)F radiopharmaceutical;
6-fluoro-L-dopa
irinotecan
[no description available]		2.4920carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug
methionine methyl ester
[no description available]		2.0810
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.08101,2,3-triazole
fluorodeoxyglucose f18
Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)		6.611402-deoxy-2-((18)F)fluoro-D-glucose;
2-deoxy-2-fluoro-aldehydo-D-glucose
erlotinib hydrochloride
[no description available]		2.2110hydrochloride;
terminal acetylenic compound		antineoplastic agent;
protein kinase inhibitor
fluorocholine
fluorocholine: a radiopharmaceutical agent		2.5520
n,n-dimethyl-n-(18f)fluoromethyl-2-hydroxyethylammonium
[no description available]		3.0240
raclopride
Raclopride: A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.		2.1310salicylamides
su 11248
[no description available]		2.110monocarboxylic acid amide;
pyrroles		angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
immunomodulator;
neuroprotective agent;
vascular endothelial growth factor receptor antagonist
gadolinium dtpa
Gadolinium DTPA: A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)		4.1531gadolinium coordination entityMRI contrast agent
2-deoxy-2-((18)F)fluoro-beta-D-glucose
[no description available]		2.05102-deoxy-2-((18)F)fluoro-D-glucopyranose;
2-deoxy-2-fluoro-beta-D-glucose
18f-faza
fluoroazomycin arabinoside: used for hypoxia-specific imaging; structure in first source		2.2110
dactolisib
dactolisib: antineoplastic agent that inhibits both phosphatidylinositol 3-kinase and mTOR. dactolisib : An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.		2.1310imidazoquinoline;
nitrile;
quinolines;
ring assembly;
ureas		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor
o-(2-fluoroethyl)tyrosine
O-(2-fluoroethyl)tyrosine: structure in first source		2.0810
dacarbazine
(E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.		2.4920dacarbazine
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		04.1350
Glial Cell Tumors
[description not available]		011.74545
Cancer of Skin
[description not available]		02.0410
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		118.74545
Skin Neoplasms
Tumors or cancer of the SKIN.		02.0410
Benign Neoplasms
[description not available]		02.7630
Sarcoma 180
An experimental sarcoma of mice.		02.0510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.7630
Benign Neoplasms, Brain
[description not available]		013.75806
Central Nervous System Neoplasm
[description not available]		02.2110
Local Neoplasm Recurrence
[description not available]		09.15164
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		013.75806
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.		02.2110
Astrocytoma, Grade IV
[description not available]		010.04303
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		010.04303
Disease Exacerbation
[description not available]		06.15101
Carcinoma, Non-Small Cell Lung
[description not available]		02.6320
Cancer of Lung
[description not available]		02.9430
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.6320
Lung Neoplasms
Tumors or cancer of the LUNG.		02.9430
Malignant Melanoma
[description not available]		02.3110
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.3110
MS (Multiple Sclerosis)
[description not available]		02.3110
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)		02.3110
Recrudescence
[description not available]		03.570
Chromosome Deletion
Actual loss of portion of a chromosome.		02.4110
Cancer of Parathyroid
[description not available]		02.1510
Parathyroid Neoplasms
Tumors or cancer of the PARATHYROID GLANDS.		02.1510
Anaplastic Astrocytoma
[description not available]		02.8130
Astrocytoma
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)		02.8130
Acquired Immune Deficiency Syndrome
[description not available]		02.1510
Innate Inflammatory Response
[description not available]		02.5120
Central Nervous System Toxoplasmosis
[description not available]		07.1510
Acquired Immunodeficiency Syndrome
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.		02.1510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.5120
Toxoplasmosis, Cerebral
Infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)		02.1510
Metastase
[description not available]		02.1510
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.1510
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.8330
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		04.13140
Injuries, Radiation
[description not available]		03.9740
Clinically Isolated CNS Demyelinating Syndrome
[description not available]		02.1710
Demyelinating Diseases
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.		02.1710
Central Nervous System Disease
[description not available]		02.1710
Besnier-Boeck Disease
[description not available]		02.1710
Central Nervous System Diseases
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.		02.1710
Sarcoidosis
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.		02.1710
Kahler Disease
[description not available]		02.0810
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.		02.0810
Cancer of Pituitary
[description not available]		02.110
Pituitary Neoplasms
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.		02.110
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.5220
Adenocarcinoma Of Kidney
[description not available]		02.110
Cancer of Kidney
[description not available]		02.110
Carcinoma, Renal Cell
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.		02.110
Kidney Neoplasms
Tumors or cancers of the KIDNEY.		02.110
Brain Stem Neoplasms, Primary
[description not available]		03.4520
Brain Stem Neoplasms
Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.		03.4520
Minimal Disease, Residual
[description not available]		02.1310
Anaplastic Oligodendroglioma
[description not available]		03.0410
Oligodendroglioma
A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)		03.0410
Aura
[description not available]		02.1510
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)		02.1510
Intradural-Extramedullary Spinal Cord Neoplasms
[description not available]		02.1510
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.		02.1510
Brain Hemorrhage, Cerebral
[description not available]		02.0510
Cerebral Hemorrhage
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.		02.0510
Carcinoma, Anaplastic
[description not available]		02.0610
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0610
Allergic Encephalomyelitis
[description not available]		02.0710