3-nitropropionic acid has been researched along with Necrosis in 15 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, induced ATP depletion and both necrosis and apoptosis in human NT2-N neurons." | 3.71 | Acute and chronic alterations in calcium homeostasis in 3-nitropropionic acid-treated human NT2-N neurons. ( Itoh, T; Lee, WT; Pleasure, D, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, S | 3 |
| Misiak, M | 3 |
| Beyer, C | 3 |
| Arnold, S | 3 |
| Drewlo, S | 1 |
| Rosenstock, TR | 1 |
| de Brito, OM | 1 |
| Lombardi, V | 1 |
| Louros, S | 1 |
| Ribeiro, M | 1 |
| Almeida, S | 1 |
| Ferreira, IL | 1 |
| Oliveira, CR | 1 |
| Rego, AC | 1 |
| Lee, WT | 1 |
| Itoh, T | 1 |
| Pleasure, D | 1 |
| Vis, JC | 1 |
| de Boer-van Huizen, RT | 1 |
| Verbeek, MM | 1 |
| de Waal, RM | 1 |
| ten Donkelaar, HJ | 1 |
| Kremer, B | 1 |
| Mogami, M | 1 |
| Hida, H | 1 |
| Hayashi, Y | 1 |
| Kohri, K | 1 |
| Kodama, Y | 1 |
| Gyun Jung, C | 1 |
| Nishino, H | 1 |
| Pang, Z | 1 |
| Bondada, V | 1 |
| Sengoku, T | 1 |
| Siman, R | 1 |
| Geddes, JW | 2 |
| Strauss, KA | 1 |
| Morton, DH | 1 |
| Hu, BH | 1 |
| Henderson, D | 1 |
| Yang, WP | 1 |
| Ho, DY | 1 |
| Saydam, TC | 1 |
| Fink, SL | 1 |
| Lawrence, MS | 1 |
| Sapolsky, RM | 1 |
| Kodsi, MH | 1 |
| Swerdlow, NR | 1 |
| Bruce-Keller, AJ | 1 |
| Knapp, PE | 1 |
| McFall, RW | 1 |
| Keller, JN | 1 |
| Holtsberg, FW | 1 |
| Parthasarathy, S | 1 |
| Steiner, SM | 1 |
| Mattson, MP | 1 |
| Allen, JW | 1 |
| Knoblach, SM | 1 |
| Faden, AI | 1 |
| Gabrielson, KL | 1 |
| Hogue, BA | 1 |
| Bohr, VA | 1 |
| Cardounel, AJ | 1 |
| Nakajima, W | 1 |
| Kofler, J | 1 |
| Zweier, JL | 1 |
| Rodriguez, ER | 1 |
| Martin, LJ | 1 |
| de Souza-Pinto, NC | 1 |
| Bressler, J | 1 |
15 other studies available for 3-nitropropionic acid and Necrosis
| Article | Year |
|---|---|
Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Survival; Cells, Cultured; Corpus Striatum; Electr | 2009 |
Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Brain Chemistr | 2010 |
Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Brain; Cell Death; Cerebral Cortex; Electron Transport | 2010 |
FK506 ameliorates cell death features in Huntington's disease striatal cell models.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Death; Cell Line; Corpus Striatum; Cytosol; D | 2011 |
Acute and chronic alterations in calcium homeostasis in 3-nitropropionic acid-treated human NT2-N neurons.
Topics: Adenosine Triphosphate; Apoptosis; Calcium; Calcium Channels; Dizocilpine Maleate; Dose-Response Rel | 2002 |
3-Nitropropionic acid induces cell death and mitochondrial dysfunction in rat corticostriatal slice cultures.
Topics: Animals; Apoptosis; Cerebral Cortex; Convulsants; Corpus Striatum; In Situ Nick-End Labeling; Mitoch | 2002 |
Estrogen blocks 3-nitropropionic acid-induced Ca2+i increase and cell damage in cultured rat cerebral endothelial cells.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Bradykinin; Brain; Calcium; Calcium Signal | 2002 |
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calpain; Caspases; Cell Death; Cell Survival; C | 2003 |
Type I glutaric aciduria, part 2: a model of acute striatal necrosis.
Topics: Brain Diseases, Metabolic, Inborn; Glutaryl-CoA Dehydrogenase; Humans; Magnetic Resonance Imaging; M | 2003 |
The impact of mitochondrial energetic dysfunction on apoptosis in outer hair cells of the cochlea following exposure to intense noise.
Topics: Animals; Apoptosis; Chinchilla; Energy Metabolism; Enzyme Inhibitors; Evoked Potentials, Auditory; H | 2008 |
Defective herpes simplex virus vectors expressing the rat brain glucose transporter protect cultured neurons from necrotic insults.
Topics: Animals; Brain; Chlorocebus aethiops; Defective Viruses; Gene Expression; Genetic Vectors; Glutamic | 1995 |
Mitochondrial toxin 3-nitropropionic acid produces startle reflex abnormalities and striatal damage in rats that model some features of Huntington's disease.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Hunting | 1997 |
Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Apoptosis; Calcium; Caspases; Cell-Free Sy | 1999 |
Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor-dependent neuronal cell death and caspase-3-dependent apoptosis.
Topics: Animals; Apoptosis; Brain Injuries; Caspase 3; Caspase Inhibitors; Caspases; Cell Death; Cells, Cult | 1999 |
Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice.
Topics: Adenosine Triphosphate; Animals; Caudate Nucleus; Dose-Response Relationship, Drug; Heart; Male; Mic | 2001 |