triprolidine and Necrosis

triprolidine has been researched along with Necrosis* in 1 studies

Other Studies

1 other study(ies) available for triprolidine and Necrosis

Article	Year
A study of the necrotic actions of the venom of the wolf spider, Lycosa godeffroyi, on mouse skin. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1990, Volume: 95, Issue:2 1. The venom of the wolf spider, Lycosa godeffroyi, caused cutaneous necrosis when injected into mice. 2. A strong inflammatory response and total loss of epidermal cellularity were features of this in vivo necrosis. 3. Mouse skin envenomated while in tissue culture showed epidermal detachment and reduced cellular adhesion. 4. Triprolidine and methysergide, used together, indomethacin, heparin and human and mouse sera all failed to inhibit the necrosis significantly. 5. The venom caused moderate haemolysis, complement consumption and inhibition of clotting, these apparently not being the main reasons for the necrosis. 6. Neither Atrax infensus venom nor hyaluronidase caused similar epithelial damage. Topics: Animals; Anti-Inflammatory Agents; Complement System Proteins; Culture Techniques; Drug Therapy, Combination; Erythrocytes; Female; Guinea Pigs; Hemolysis; Methysergide; Mice; Mice, Inbred Strains; Necrosis; Periosteum; Prothrombin Time; Scalp; Scalp Dermatoses; Skin; Skin Diseases; Spider Venoms; Triprolidine	1990

Article

Year

A study of the necrotic actions of the venom of the wolf spider, Lycosa godeffroyi, on mouse skin.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1990, Volume: 95, Issue:2

1. The venom of the wolf spider, Lycosa godeffroyi, caused cutaneous necrosis when injected into mice. 2. A strong inflammatory response and total loss of epidermal cellularity were features of this in vivo necrosis. 3. Mouse skin envenomated while in tissue culture showed epidermal detachment and reduced cellular adhesion. 4. Triprolidine and methysergide, used together, indomethacin, heparin and human and mouse sera all failed to inhibit the necrosis significantly. 5. The venom caused moderate haemolysis, complement consumption and inhibition of clotting, these apparently not being the main reasons for the necrosis. 6. Neither Atrax infensus venom nor hyaluronidase caused similar epithelial damage.

Topics: Animals; Anti-Inflammatory Agents; Complement System Proteins; Culture Techniques; Drug Therapy, Combination; Erythrocytes; Female; Guinea Pigs; Hemolysis; Methysergide; Mice; Mice, Inbred Strains; Necrosis; Periosteum; Prothrombin Time; Scalp; Scalp Dermatoses; Skin; Skin Diseases; Spider Venoms; Triprolidine

1990