Page last updated: 2024-08-07 15:26:39

Voltage-dependent L-type calcium channel subunit alpha-1F

A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60840]

Synonyms

Voltage-gated calcium channel subunit alpha Cav1.4

Research

Bioassay Publications (9)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's7 (77.78)24.3611
2020's0 (0.00)2.80

Compounds (67)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gallopamilHomo sapiens (human)IC500.011011
gallopamilHomo sapiens (human)Ki0.005411
phenytoinHomo sapiens (human)IC5021.900011
tacrineHomo sapiens (human)IC5017.000011
amiodaroneHomo sapiens (human)IC501.085022
amitriptylineHomo sapiens (human)IC5011.600011
astemizoleHomo sapiens (human)IC501.100011
bepridilHomo sapiens (human)IC501.000011
verapamilHomo sapiens (human)IC500.200011
chlorpromazineHomo sapiens (human)IC503.400011
cifenlineHomo sapiens (human)IC5030.000011
cilostazolHomo sapiens (human)IC5091.200011
cisaprideHomo sapiens (human)IC5011.800011
diazepamHomo sapiens (human)IC5030.500011
disopyramideHomo sapiens (human)IC501,036.700011
donepezilHomo sapiens (human)IC5034.300011
droperidolHomo sapiens (human)IC507.600011
flecainideHomo sapiens (human)IC5027.100011
haloperidolHomo sapiens (human)IC501.500022
imipramineHomo sapiens (human)IC508.300011
loratadineHomo sapiens (human)IC5011.400011
methadoneHomo sapiens (human)IC5037.400011
metronidazoleHomo sapiens (human)IC50177.900011
mexiletineHomo sapiens (human)IC50100.000011
mitoxantroneHomo sapiens (human)IC5022.500011
nifedipineHomo sapiens (human)IC507.356733
nifedipineHomo sapiens (human)Ki0.014712
nimodipineHomo sapiens (human)IC5014.000011
nitrendipineHomo sapiens (human)IC500.015222
pentobarbitalHomo sapiens (human)IC50299.000011
procainamideHomo sapiens (human)IC50389.500011
risperidoneHomo sapiens (human)IC5034.200011
sotalolHomo sapiens (human)IC50193.300011
terfenadineHomo sapiens (human)IC500.930011
thioridazineHomo sapiens (human)IC503.500011
pimozideHomo sapiens (human)IC500.201022
terodilineHomo sapiens (human)IC504.800011
halofantrineHomo sapiens (human)IC501.900011
ribavirinHomo sapiens (human)IC50622.500011
diltiazemHomo sapiens (human)IC500.605022
piperacillinHomo sapiens (human)IC501,226.000011
paroxetineHomo sapiens (human)IC503.900011
sertindoleHomo sapiens (human)IC507.600022
sparfloxacinHomo sapiens (human)IC5088.800011
mibefradilHomo sapiens (human)IC500.333022
ibutilideHomo sapiens (human)IC5062.500011
lamivudineHomo sapiens (human)IC5054.200011
duloxetineHomo sapiens (human)IC502.800011
uk 68798Homo sapiens (human)IC5043.350022
voriconazoleHomo sapiens (human)IC50414.200011
paliperidoneHomo sapiens (human)IC50193.900011
moxifloxacinHomo sapiens (human)IC50173.000011
solifenacinHomo sapiens (human)IC504.300011
telbivudineHomo sapiens (human)IC50713.900011
quinidineHomo sapiens (human)IC506.400011
saquinavirHomo sapiens (human)IC501.900011
linezolidHomo sapiens (human)IC50105.400011
s 1033Homo sapiens (human)IC504.700011
dasatinibHomo sapiens (human)IC5081.100011
sitagliptinHomo sapiens (human)IC50147.100011
l 745870Homo sapiens (human)IC509.000011
su 11248Homo sapiens (human)IC5033.400011
ceftriaxoneHomo sapiens (human)IC50153.800011
ith 4012Homo sapiens (human)IC5020.000011
raltegravirHomo sapiens (human)IC50246.700011
ajmalineHomo sapiens (human)IC5071.000011
clozapineHomo sapiens (human)IC503.600011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sumatriptanHomo sapiens (human)EC500.012011
l 772405Homo sapiens (human)EC500.000811

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
voltage-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
high voltage-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
photoreceptor outer segmentcellular componentThe outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
perikaryoncellular componentThe portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
voltage-gated calcium channel complexcellular componentA protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 3 target(s):

TargetCategoryDefinition
visual perceptionbiological processThe series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai]
detection of light stimulus involved in visual perceptionbiological processThe series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]
calcium ion import across plasma membranebiological processThe directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]