Page last updated: 2024-08-07 15:26:39
Voltage-dependent L-type calcium channel subunit alpha-1F
A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60840]
Synonyms
Voltage-gated calcium channel subunit alpha Cav1.4
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (67)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gallopamil | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| gallopamil | Homo sapiens (human) | Ki | 0.0054 | 1 | 1 |
| phenytoin | Homo sapiens (human) | IC50 | 21.9000 | 1 | 1 |
| tacrine | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| amiodarone | Homo sapiens (human) | IC50 | 1.0850 | 2 | 2 |
| amitriptyline | Homo sapiens (human) | IC50 | 11.6000 | 1 | 1 |
| astemizole | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| bepridil | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| verapamil | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| chlorpromazine | Homo sapiens (human) | IC50 | 3.4000 | 1 | 1 |
| cifenline | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| cilostazol | Homo sapiens (human) | IC50 | 91.2000 | 1 | 1 |
| cisapride | Homo sapiens (human) | IC50 | 11.8000 | 1 | 1 |
| diazepam | Homo sapiens (human) | IC50 | 30.5000 | 1 | 1 |
| disopyramide | Homo sapiens (human) | IC50 | 1,036.7000 | 1 | 1 |
| donepezil | Homo sapiens (human) | IC50 | 34.3000 | 1 | 1 |
| droperidol | Homo sapiens (human) | IC50 | 7.6000 | 1 | 1 |
| flecainide | Homo sapiens (human) | IC50 | 27.1000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | IC50 | 1.5000 | 2 | 2 |
| imipramine | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| loratadine | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| methadone | Homo sapiens (human) | IC50 | 37.4000 | 1 | 1 |
| metronidazole | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
| mexiletine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| mitoxantrone | Homo sapiens (human) | IC50 | 22.5000 | 1 | 1 |
| nifedipine | Homo sapiens (human) | IC50 | 7.3567 | 3 | 3 |
| nifedipine | Homo sapiens (human) | Ki | 0.0147 | 1 | 2 |
| nimodipine | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| nitrendipine | Homo sapiens (human) | IC50 | 0.0152 | 2 | 2 |
| pentobarbital | Homo sapiens (human) | IC50 | 299.0000 | 1 | 1 |
| procainamide | Homo sapiens (human) | IC50 | 389.5000 | 1 | 1 |
| risperidone | Homo sapiens (human) | IC50 | 34.2000 | 1 | 1 |
| sotalol | Homo sapiens (human) | IC50 | 193.3000 | 1 | 1 |
| terfenadine | Homo sapiens (human) | IC50 | 0.9300 | 1 | 1 |
| thioridazine | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| pimozide | Homo sapiens (human) | IC50 | 0.2010 | 2 | 2 |
| terodiline | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| halofantrine | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| ribavirin | Homo sapiens (human) | IC50 | 622.5000 | 1 | 1 |
| diltiazem | Homo sapiens (human) | IC50 | 0.6050 | 2 | 2 |
| piperacillin | Homo sapiens (human) | IC50 | 1,226.0000 | 1 | 1 |
| paroxetine | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| sertindole | Homo sapiens (human) | IC50 | 7.6000 | 2 | 2 |
| sparfloxacin | Homo sapiens (human) | IC50 | 88.8000 | 1 | 1 |
| mibefradil | Homo sapiens (human) | IC50 | 0.3330 | 2 | 2 |
| ibutilide | Homo sapiens (human) | IC50 | 62.5000 | 1 | 1 |
| lamivudine | Homo sapiens (human) | IC50 | 54.2000 | 1 | 1 |
| duloxetine | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| uk 68798 | Homo sapiens (human) | IC50 | 43.3500 | 2 | 2 |
| voriconazole | Homo sapiens (human) | IC50 | 414.2000 | 1 | 1 |
| paliperidone | Homo sapiens (human) | IC50 | 193.9000 | 1 | 1 |
| moxifloxacin | Homo sapiens (human) | IC50 | 173.0000 | 1 | 1 |
| solifenacin | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| telbivudine | Homo sapiens (human) | IC50 | 713.9000 | 1 | 1 |
| quinidine | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| saquinavir | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| linezolid | Homo sapiens (human) | IC50 | 105.4000 | 1 | 1 |
| s 1033 | Homo sapiens (human) | IC50 | 4.7000 | 1 | 1 |
| dasatinib | Homo sapiens (human) | IC50 | 81.1000 | 1 | 1 |
| sitagliptin | Homo sapiens (human) | IC50 | 147.1000 | 1 | 1 |
| l 745870 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| su 11248 | Homo sapiens (human) | IC50 | 33.4000 | 1 | 1 |
| ceftriaxone | Homo sapiens (human) | IC50 | 153.8000 | 1 | 1 |
| ith 4012 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| raltegravir | Homo sapiens (human) | IC50 | 246.7000 | 1 | 1 |
| ajmaline | Homo sapiens (human) | IC50 | 71.0000 | 1 | 1 |
| clozapine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sumatriptan | Homo sapiens (human) | EC50 | 0.0120 | 1 | 1 |
| l 772405 | Homo sapiens (human) | EC50 | 0.0008 | 1 | 1 |
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| high voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| photoreceptor outer segment | cellular component | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| perikaryon | cellular component | The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated calcium channel complex | cellular component | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| visual perception | biological process | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai] |
| detection of light stimulus involved in visual perception | biological process | The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos] |
| calcium ion import across plasma membrane | biological process | The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |