Proteins > Voltage-dependent L-type calcium channel subunit alpha-1F
Page last updated: 2024-08-07 15:26:39
Voltage-dependent L-type calcium channel subunit alpha-1F
A voltage-dependent L-type calcium channel subunit alpha-1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:O60840]
Synonyms
Voltage-gated calcium channel subunit alpha Cav1.4
Research
Bioassay Publications (9)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (11.11) | 18.2507 |
2000's | 1 (11.11) | 29.6817 |
2010's | 7 (77.78) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (67)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
sumatriptan | Homo sapiens (human) | EC50 | 0.0120 | 1 | 1 |
l 772405 | Homo sapiens (human) | EC50 | 0.0008 | 1 | 1 |
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine HJournal of medicinal chemistry, , 12-26, Volume: 62, Issue:24, 2019
Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
MICE models: superior to the HERG model in predicting Torsade de Pointes.Scientific reports, , Volume: 3, 2013
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.Cardiovascular research, , Jul-01, Volume: 91, Issue:1, 2011
Enables
This protein enables 3 target(s):
Target | Category | Definition |
voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729] |
metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
high voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] |
Located In
This protein is located in 3 target(s):
Target | Category | Definition |
photoreceptor outer segment | cellular component | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304] |
membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
perikaryon | cellular component | The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl] |
Part Of
This protein is part of 1 target(s):
Target | Category | Definition |
voltage-gated calcium channel complex | cellular component | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah] |
Involved In
This protein is involved in 3 target(s):
Target | Category | Definition |
visual perception | biological process | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai] |
detection of light stimulus involved in visual perception | biological process | The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos] |
calcium ion import across plasma membrane | biological process | The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |