Page last updated: 2024-08-08 00:32:44

Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

A phosphatidylinositol 4-phosphate 5-kinase type-1 gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60331]

Synonyms

PIP5K1gamma;
PtdIns(4)P-5-kinase 1 gamma;
EC 2.7.1.68;
Type I phosphatidylinositol 4-phosphate 5-kinase gamma

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (69)

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
imatinibHomo sapiens (human)Kd10.000011
staurosporineHomo sapiens (human)Kd2.700011
gefitinibHomo sapiens (human)Kd10.000011
lestaurtinibHomo sapiens (human)Kd10.000011
vatalanibHomo sapiens (human)Kd10.000011
ruboxistaurinHomo sapiens (human)Kd0.510011
canertinibHomo sapiens (human)Kd10.000011
birb 796Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd2.600011
enzastaurinHomo sapiens (human)Kd6.600011
erlotinibHomo sapiens (human)Kd10.000011
lapatinibHomo sapiens (human)Kd10.000011
sorafenibHomo sapiens (human)Kd10.000011
pd 173955Homo sapiens (human)Kd10.000011
s 1033Homo sapiens (human)Kd10.000011
bms 387032Homo sapiens (human)Kd10.000011
tandutinibHomo sapiens (human)Kd10.000011
vx-745Homo sapiens (human)Kd10.000011
dasatinibHomo sapiens (human)Kd10.000011
zd 6474Homo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd2.600011
bosutinibHomo sapiens (human)Kd10.000011
su 11248Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd10.000011
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd10.000011
ki 20227Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000011
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000011
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd10.000011
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd1.900011
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd10.000011
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd0.310011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.130011
brivanibHomo sapiens (human)Kd10.000011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd10.000011
kw 2449Homo sapiens (human)Kd10.000011
abt 869Homo sapiens (human)Kd10.000011
gw 2580Homo sapiens (human)Kd10.000011
crizotinibHomo sapiens (human)Kd10.000011
chir-265Homo sapiens (human)Kd10.000011
motesanibHomo sapiens (human)Kd10.000011
mln8054Homo sapiens (human)Kd10.000011
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd6.700011
azd 1152-hqpaHomo sapiens (human)Kd10.000011
nvp-tae684Homo sapiens (human)Kd10.000011
fedratinibHomo sapiens (human)Kd10.000011
gsk690693Homo sapiens (human)Kd1.500011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd10.000011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd10.000011
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd10.000011
chir 258Homo sapiens (human)Kd4.300011
nintedanibHomo sapiens (human)Kd10.000011
pp242Homo sapiens (human)Kd0.018011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
1-phosphatidylinositol-4-phosphate 5-kinase activitymolecular functionCatalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+. [EC:2.7.1.68, RHEA:14425]
phosphatidylinositol kinase activitymolecular functionCatalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. [GOC:ai]

Located In

This protein is located in 9 target(s):

TargetCategoryDefinition
phagocytic cupcellular componentAn invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. [PMID:10358769]
uropodcellular componentA membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
adherens junctioncellular componentA cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]
focal adhesioncellular componentA cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
endosome membranecellular componentThe lipid bilayer surrounding an endosome. [GOC:mah]
ruffle membranecellular componentThe portion of the plasma membrane surrounding a ruffle. [GOC:mah]
presynapsecellular componentThe part of a synapse that is part of the presynaptic cell. [GOC:dos]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 12 target(s):

TargetCategoryDefinition
phosphatidylinositol biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]
phagocytosisbiological processA vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732]
synaptic vesicle exocytosisbiological processFusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. [GOC:jid, GOC:lmg]
actin cytoskeleton organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]
neutrophil chemotaxisbiological processThe directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732]
adherens junction assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. [GOC:aruk, GOC:bc, GOC:mah]
synaptic vesicle endocytosisbiological processA vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionbiological processAny process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
membrane organizationbiological processA process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. [GOC:dph, GOC:tb]
clathrin-dependent endocytosisbiological processAn endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]
cell-cell adhesionbiological processThe attachment of one cell to another cell via adhesion molecules. [GOC:dos]
phosphatidylinositol phosphate biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732]